First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease
Conclusions
This study demonstrated the feasibility, safety, and accuracy of the MRgFUS PTT. To obtain similar results as the ones of RF PTT, it was necessary to integrate the fact that white matter, in this case, the pallidothalamic tract, requires repeated thermal exposition to achieve full lesioning and thus full therapeutic effect. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - May 31, 2014 Category: Radiology Source Type: research
Women seeking second opinion for symptomatic uterine leiomyoma: role of comprehensive fibroid center
Conclusions
Multidisciplinary fibroid evaluation may facilitate the increase use of less invasive options over hysterectomy for symptomatic fibroid treatment. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - April 15, 2014 Category: Radiology Source Type: research
Focused ultrasound to displace renal calculi: threshold for tissue injury
Conclusions
The data obtained from this study show that exposure of kidneys to ultrasonic propulsion for displacing renal calculi is well below the threshold for tissue injury. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 31, 2014 Category: Radiology Source Type: research
Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study
Conclusions
Ultrasound application enhanced the delivery of an anti-inflammatory ocular drug, dexamethasone sodium phosphate, through the cornea in vivo. Ultrasound-enhanced ocular drug delivery appears to be a promising area of research with a potential future application in a clinical setting. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 31, 2014 Category: Radiology Source Type: research
Focused ultrasound development and clinical adoption: 2013 update on the growth of the field
We present here a snapshot of the field of focused ultrasound and describe how it has progressed over the past several decades. It is assessed using metrics which include quantity and breadth of academic work (presentations, publications), funding trends, manufacturer presence in the field, number of treated patients, number of indications reaching first-in-human status, and quantity and breadth of clinical indications. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 27, 2014 Category: Radiology Source Type: research
Intense focused ultrasound stimulation can safely stimulate inflamed subcutaneous tissue and assess allodynia
Conclusions
Given that there exist systems to guide iFU deep to the skin, image-guided iFU may one day allow assessment of patient’s deep, peripheral pain generators. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 25, 2014 Category: Radiology Source Type: research
Ultrasound stimulation increases proliferation of MC3T3-E1 preosteoblast-like cells
Conclusion
This study concludes that a short-term stimulation with optimum intensity can enhance proliferation of preosteoblast-like bone cells that plays an important role in bone formation and accelerated fracture healing, also suggesting a possible therapeutic treatment for reduced bone mass. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - January 2, 2014 Category: Radiology Source Type: research
Trans-cranial focused ultrasound without hair shaving: feasibility study in an ex vivo cadaver model
Abstract
In preparing a patient for a trans-cranial magnetic resonance (MR)-guided focused ultrasound procedure, current practice is to shave the patient’s head on treatment day. Here we present an initial attempt to evaluate the feasibility of trans-cranial focused ultrasound in an unshaved, ex vivo human head model. A human skull filled with tissue-mimicking phantom and covered with a wig made of human hair was sonicated using 220- and 710-kHz head transducers to evaluate the feasibility of acoustic energy transfer. Heating at the focal point was measured by MR proton resonance shift thermometry. Re...
Source: Journal of Therapeutic Ultrasound - January 2, 2014 Category: Radiology Source Type: research
MR-guided focused ultrasound (MRgFUS) is effective for the distinct pattern of uterine fibroids seen in African-American women: data from phase III/IV, non-randomized, multicenter clinical trials
Conclusion
Despite differences in the pattern of fibroid disease, MRgFUS for uterine fibroids has a similar efficacy for AA women compared with non-AA women. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 2, 2013 Category: Radiology Source Type: research
In vitro methods for evaluating therapeutic ultrasound exposures: present-day models and future innovations
Abstract
Although preclinical experiments are ultimately required to evaluate new therapeutic ultrasound exposures and devices prior to clinical trials, in vitro experiments can play an important role in the developmental process. A variety of in vitro methods have been developed, where each of these has demonstrated their utility for various test purposes. These include inert tissue-mimicking phantoms, which can incorporate thermocouples or cells and ex vivo tissue. Cell-based methods have also been used, both in monolayer and suspension. More biologically relevant platforms have also shown utility, su...
Source: Journal of Therapeutic Ultrasound - November 1, 2013 Category: Radiology Source Type: research
Transcranial sonothrombolysis using high-intensity focused ultrasound: impact of increasing output power on clot fragmentation
Conclusion
Transcranial sonothrombolysis could be achieved in vitro within seconds in the absence of tPA and without producing relevant clot fragmentation, using acoustic output powers of <400 W. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 1, 2013 Category: Radiology Source Type: research
Safety of MR-guided focused ultrasound treatment of pedunculated subserosal uterine leiomyomas
Conclusions
Pedunculated subserosal leiomyomas are not a contraindication to treatment by MRgFUS. We found no evidence of complications specifically related to pedunculated subserosal leiomyomas. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - October 1, 2013 Category: Radiology Source Type: research
Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis
Abstract
The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). U...
Source: Journal of Therapeutic Ultrasound - October 1, 2013 Category: Radiology Source Type: research
Safety and treatment volumes achieved following new developments of the magnetic resonance-guided focused ultrasound system in the treatment of uterine fibroids: a cohort study
Conclusion
Overall, the new system has thus far shown an encouraging safety record and an improvement in non-perfused volumes achieved, especially in hyper-intense fibroids. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - October 1, 2013 Category: Radiology Source Type: research
Correction: MR-guided focused ultrasound technique in functional neurosurgery: targeting accuracy
(Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - September 27, 2013 Category: Radiology Source Type: research
