Effect of applied energy in renal sympathetic denervation with magnetic resonance guided focused ultrasound in a porcine model
ConclusionsWhile MR guided focused ultrasound renal denervation was found to be safe and effective in this normotensive animal model, the results indicated the need to incorporate patient-specific details in the treatment planning of MRgFUS renal denervation procedure. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - June 12, 2017 Category: Radiology Source Type: research
Acoustic and thermal characterization of agar based phantoms used for evaluating focused ultrasound exposures
ConclusionsThe proposed phantom closely matched the acoustic and thermal properties of tissues. Experiments using MR thermometry demonstrated the usefulness of this phantom to evaluate ultrasonic exposures. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - June 1, 2017 Category: Radiology Source Type: research
Spatially-segmented undersampled MRI temperature reconstruction for transcranial MR-guided focused ultrasound
ConclusionsSeparate reconstruction of brain and water bath signals enables accelerated MR temperature imaging during MRgFUS procedures with low errors due to undersampling using Cartesian and non-Cartesian trajectories. The spatially-segmented method benefits from multiple coils, and reconstructs temperature with lower error compared to measurements from SENSE-reconstructed images. The acceleration can be applied to increase volumetric coverage and spatiotemporal resolution. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - May 30, 2017 Category: Radiology Source Type: research
High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules – a systematic review
ConclusionsDespite the few number of studies, our review appeared to suggest that HIFU is a safe and efficacious method of treating symptomatic benign thyroid nodules. However, larger-scale, prospective trials with longer follow-up period are indeed required to confirm this. In terms of the ablation itself, relative to other ablation techniques, there are still much room for improvements in shortening treatment duration and expanding the range of treatable nodules. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - May 17, 2017 Category: Radiology Source Type: research
Theoretical investigation of transgastric and intraductal approaches for ultrasound-based thermal therapy of the pancreas
ConclusionsThis study demonstrated the feasibility of generating shaped or conformal ablative or hyperthermic temperature distributions within pancreatic tumors using transgastric or intraductal ultrasound. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - May 3, 2017 Category: Radiology Source Type: research
Multi-focal HIFU reduces cavitation in mild-hyperthermia
ConclusionsMulti-focal HIFU can be used to achieve mild temperature elevation and reduce cavitation activity. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - April 13, 2017 Category: Radiology Source Type: research
A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound
ConclusionsHIFU appears to be an effective tool for pain palliation in advanced pancreatic cancer. Studies assessing treatment in patients with pancreatic adenocarcinoma are limited by factors such as small sample sizes and heterogeneity in clinical definitions and assessments. Prospective randomized and standardized studies are necessary to confirm the effectiveness of HIFU in relieving pain, and to evaluate for any potential impact on tumor control and patient survival. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - April 1, 2017 Category: Radiology Source Type: research
International Society for Therapeutic Ultrasound Conference 2016
(Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 16, 2017 Category: Radiology Source Type: research
Long-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma
ConclusionsUS-guided HIFU represents a promising non-invasive method with sustainable FA volume reduction and patient ’s tolerability. Although one treatment is highly efficient, the volume reduction can be increased with second treatment.Trial registrationNCT01331954. Registered 07 April 2011. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 15, 2017 Category: Radiology Source Type: research
Microvessel rupture induced by high-intensity therapeutic ultrasound —a study of parameter sensitivity in a simple in vivo model
ConclusionThe results provide a database with which investigations in more complex animal models can be compared, potentially establishing trends by which bioeffects in human vessels can be estimated. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 1, 2017 Category: Radiology Source Type: research
Objective image analysis of real-time three-dimensional intraoperative ultrasound for intrinsic brain tumour surgery
ConclusionsMPB and SD are objective measures reflecting the sensitivity of i3DUS in detecting the presence and extent of intrinsic brain tumours. They indirectly suggest heterogeneity, cellularity and invasiveness, providing information of the nature of the tumour, and also reflect the sensitivity of intraoperative US to detect the presence of residual intrinsic brain tumours. Development of this paradigm will enhance i3DUS use as an adjunct in brain tumour surgery. Optimizing its intraoperative application will impact surgical resection and, hence, patient outcome. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 15, 2017 Category: Radiology Source Type: research
Moderate-to-deep sedation technique, using propofol and ketamine, allowing synchronised breathing for magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids: a pilot study
ConclusionsThe use of a specific combination of IV propofol and esketamine for procedural sedation and analgesia reduced the discomfort and pain during MR-guided HIFU treatments of uterine fibroids. The resulting regular breathing pattern allowed for easy synchronisation of the MR-HIFU procedure. Based on our results, esketamine and propofol sedation performed by trained non-medical sedation practitioners is feasible and safe, has a low risk of major adverse events, and has a short recovery time, avoiding a session of general anaesthesia. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 8, 2017 Category: Radiology Source Type: research
MRgFUS for desmoid tumors within the thigh: early clinical experiences
ConclusionsMRgFUS is an effective treatment for desmoid tumors of the thigh with a favorable side effect profile, allowing for repeated treatments if necessary. Ablation size and safety can be improved with far-field coupling devices, careful patient positioning, and optimized sonication planning. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 2, 2017 Category: Radiology Source Type: research
Why we should care about soft tissue interfaces when applying ultrasonic diathermy: an experimental and computer simulation study
ConclusionsThis work suggests that more attention should be given to soft tissue layer interfaces in ultrasound therapeutic procedures even in the absence of a close bone layer. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - January 26, 2017 Category: Radiology Source Type: research
An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro
ConclusionsWe conclude that PCCAs can be used to induce the sonoporation of cells in vitro, and our results warrant further investigation into the use of PCCAs as extravascular sonoporation agents in vivo. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - January 23, 2017 Category: Radiology Source Type: research
