Experimental study of beam distortion due to fiducial markers during salvage HIFU in the prostate
ConclusionsThe presence of an EBRT fiducial marker may result in an undertreated region beyond the marker due to reduced energy arriving at the focus, and an overtreated region in front of the marker due to reflections. Depending on the position of the targeted regions and the distribution of the markers, both effects may be undesirable and reduce treatment efficacy. Further work is necessary to investigate whether these results indicate the necessity to reconsider patient selection and treatment planning for prostate salvage HIFU after failed EBRT. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - March 22, 2018 Category: Radiology Source Type: research
Calcium-dependent ultrasound stimulation of secretory events from pancreatic beta cells
ConclusionsOur results demonstrated that application of ultrasound was capable of stimulating the release of insulin from pancreatic beta cells in a safe, controlled and Ca2+-dependent manner. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 5, 2017 Category: Radiology Source Type: research
Multiple ultrasound cavitation-enabled treatments for myocardial reduction
ConclusionThe ability to fractionate treatment may be advantageous for optimizing patient outcome relative to all-or nothing therapy by surgical myectomy or alcohol ablation. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 9, 2017 Category: Radiology Source Type: research
Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox ®) using focused ultrasound in patients with liver tumours
DiscussionIf this early phase study can demonstrate that ultrasound-mediated hyperthermia can effectively enhance the delivery and penetration of chemotherapy agents intratumorally, it could enable application of the technique to enhance therapeutic outcomes across a broad range of drug classes to treat solid tumours.Trial registrationClinicalTrials.gov Identifier:NCT02181075, Edura-CT Identifier: 2014-000514-61.Ethics Number: 14/NE/0124. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 2, 2017 Category: Radiology Source Type: research
A framework for continuous target tracking during MR-guided high intensity focused ultrasound thermal ablations in the abdomen
ConclusionsIn the current study we proposed an image-based motion compensation framework dedicated to MRg-HIFU thermal ablations in the abdomen, providing the possibility to re-optimize the therapy plan on-the-fly with the patient on the interventional table. Moreover, we have demonstrated that even under clinical conditions, the proposed approach is fully capable of continuously ensuring the spatial fidelity between the different phases of the therapeutic work-flow. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - October 9, 2017 Category: Radiology Source Type: research
Current and emerging brain applications of MR-guided focused ultrasound
AbstractMRI guided focused ultrasound is an emerging technique that uses acoustic energy to noninvasively treat intracranial disorders. At high frequencies, it can be used to raise tissue temperatures and ablate discrete brain targets with sub-millimeter accuracy. This application is currently under investigation for a broad range of clinical applications, including brain tumors, movement disorders, and psychiatric conditions. At low frequencies MRI guided focused ultrasound can be used to modulate neuronal activity and in conjunction with injected microbubbles, can open the blood-brain barrier to enhance the delivery of t...
Source: Journal of Therapeutic Ultrasound - October 5, 2017 Category: Radiology Source Type: research
Magnetic Resonance-guided High Intensity Focused Ultrasound in the presence of biopsy markers
ConclusionAll markers had a minimal impact on the volume above the thermal dose threshold of 240 EM since the differences measured were smaller than the in-plane image resolution of 1.56 mm. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - September 20, 2017 Category: Radiology Source Type: research
