Journal of the International Association of Physicians in AIDS Care (JIAPAC) This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cyclophosphamide Treatment for Acquired Factor VIII Inhibitor in a Patient with AIDS-Associated Progressive Multifocal Leukoencephalopathy
We describe the case of a man with a long history of AIDS complicated by progressive multifocal leukoencephalopathy (PML), who developed AHA while on stable antiretroviral therapy and then presented with new onset bleeding and hypotension. We treated our patient with incrementally increasing doses of cyclophosphamide resulting in resolution of coagulopathy. We review the medical literature for additional cases of HIV-associated AHA and discuss the challenges in the care of our patient, since the immunosuppression needed to eradicate the FVIII inhibitor had the potential to cause recrudescence of his PML. (Source: Journal o...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - March 16, 2016 Category: Infectious Diseases Authors: Malhotra, U., Aboulafia, D. M. Tags: Case Reports Source Type: research

Fecal Transplantation for Clostridium Difficile--"All Stool May Not Be Created Equal"
We present a 62-year-old African American female with a long history of HIV infection, who presented with abdominal pain and continuous diarrhea due to pseudomembranous colitis. After failing multiple episodes of conventional therapy, it was decided to treat her with fecal microbiota transplantation. Fecal microbiota transplantation was given on 3 separate occasions from a biological-related donor without success. It was only after a fourth transplant was done with a nonrelated donor that the patient resolved her diarrhea within 48 hours. We suggest that fecal samples from different donors have different abilities to cure ...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - March 16, 2016 Category: Infectious Diseases Authors: Gathe, J. C., Diejomaoh, E. M., Mayberry, C. C., Clemmons, J. B. Tags: Case Reports Source Type: research

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country
Conclusion: The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - March 16, 2016 Category: Infectious Diseases Authors: Khazraiyan, H., Liaei, Z. A., Koochak, H. E., Ardalan, F. A., Ahmadinejad, Z., Soltani, A. Tags: Drugs & amp;amp; Diagnostics Source Type: research

Pattern, Determinants, and Impact of HIV Spending on Care and Treatment in 38 High-Burden Low- and Middle-Income Countries
Discussion: HIV spending in high-burden LMICs does not consistently reflect the new science around the preventative and clinical benefits of earlier HIV diagnosis and ART initiation. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - March 16, 2016 Category: Infectious Diseases Authors: Granich, R., Gupta, S., Montaner, J., Williams, B., Zuniga, J. M. Tags: Public Policy & amp;amp; Finance Source Type: research

Evaluating the Impact of a Pharmacist-Led Antiretroviral Stewardship Program on Reducing Drug Interactions in HIV-Infected Patients
Conclusion: An ARVSP is critical in the prevention of CSDDIs and errors to improve safety in HIV-infected patients. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Billedo, J. A. S., Berkowitz, L. B., Cha, A. Tags: Antiretroviral Therapy Source Type: research

Clinical Utility of Pharmacy-Based Adherence Measurement in Predicting Virologic Outcomes in an Adult HIV-Infected Cohort in Jos, North Central Nigeria
Conclusion: Adherence to drug refill is a useful predictor of successful virologic control and could be utilized for routine monitoring of adherence to cART in our clinical setting. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Abah, I. O., Ojeh, V. B., Musa, J., Ugoagwu, P., Agaba, P. A., Agbaji, O., Okonkwo, P. Tags: Antiretroviral Therapy Source Type: research

Economic Burden of HIV Antiretroviral Therapy Adverse Events in the United States
Conclusion: Health care costs of ART AEs should be key consideration for payers/providers in HIV management. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Dekoven, M., Makin, C., Slaff, S., Marcus, M., Maiese, E. M. Tags: Antiretroviral Therapy Source Type: research

A Clinical Home for Preexposure Prophylaxis: Diverse Health Care Providers Perspectives on the "Purview Paradox"
Conclusion: Although there may be multiple "homes" for PrEP, implementation research is needed to identify the most effective delivery approaches. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Hoffman, S., Guidry, J. A., Collier, K. L., Mantell, J. E., Boccher-Lattimore, D., Kaighobadi, F., Sandfort, T. G. M. Tags: Antiretroviral Therapy Source Type: research

The Impact of Key HIV Intervention Components as Predictors of Sexual Barrier Use: The Zambia Partner Project
This study examined the relative impact of elements of the intervention as predictors of condom use. Changes in acceptability had the greatest overall influence on condom use, followed by social support, relationship consensus, and willingness to use condoms. Changes in self-efficacy, IPV, negotiation, and information had no influence. Results support the use of multidimensional approaches in behavioral interventions and highlight the importance of identifying critical elements of interventions to maximize risk reduction outcomes. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Chitalu, N., Mumbi, M., Cook, R., Weiss, S. M., Jones, D. Tags: HIV Clinical Management Source Type: research

Investigation of HIV Incidence Rates in a High-Risk, High-Prevalence Kenyan Population: Potential Lessons for Intervention Trials and Programmatic Strategies
Cost-effective HIV prevention programs should target persons at high risk of HIV acquisition. We conducted an observational HIV incidence cohort study in Kisumu, Kenya, where HIV prevalence is triple that of the national rate. We used referral and venue-sampling approaches to enroll HIV-negative persons for a 12-month observational cohort, August 2010 to September 2011, collected data using computer-assisted interviews, and performed HIV testing quarterly. Among 1292 eligible persons, 648 (50%) were excluded for HIV positivity and other reasons. Of the 644 enrollees, 52% were women who were significantly older than men (P ...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Mdodo, R., Gust, D., Otieno, F. O., McLellan-Lemal, E., Chen, R. T., LeBaron, C., Hardnett, F., Turner, K., Ndivo, R., Zeh, C., Samandari, T., Mills, L. A. Tags: HIV Clinical Management Source Type: research

Characteristics of Sexually Transmitted Infections among High-Risk HIV-Positive Patients Attending an Urban Clinic in Uganda
Conclusion: Clinical and microbiologically diagnosed STIs were diagnosed in nearly one-fourth of the HIV-positive high-risk population. HIV care programs should note our high rates of STIs among HIV-positive high-risk populations and consider routine screening and treatment algorithms for these populations in their own settings. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Katusiime, C., Schlech, W. F., Parkes-Ratanshi, R., Sempa, J., Kambugu, A. Tags: HIV Clinical Management Source Type: research

Gender Differences in Severity and Correlates of Depression Symptoms in People Living with HIV in Ontario, Canada
This study investigates the differences in severity and correlates of depression symptoms among 1069 men and 267 women living with HIV in Ontario, Canada, who completed the 20-item Center for Epidemiologic Studies Depression Scale (CES-D). Women had higher CES-D scores than that of men (median [interquartile range]: 13 [5-26] versus 9 [3-20], P = .0004). More women had total CES-D scores >15 (mild-moderate depression; 44% versus 33%, P = .002) and >21 (severe depression; 31% versus 23%, P = .003). Unlike men, at age 40, women’s scores increased yearly (0.4 per increased year, P = .005). The distribution of scor...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Aljassem, K., Raboud, J. M., Hart, T. A., Benoit, A., Su, D., Margolese, S. L., Rourke, S. B., Rueda, S., Burchell, A., Cairney, J., Shuper, P., Loutfy, M. R., and the OHTN Cohort Study Research Team Tags: HIV Clinical Management Source Type: research

Epilepsia Partialis Continua as Presenting Manifestation of AIDS: A Rarity
We report the case of a teenaged boy with no past significant history or known high-risk behavior who presented with recurrent focal seizures of 5 days’ duration, EPC, and encephalopathy. His electroencephalogram showed periodic lateralized epileptiform discharges (PLEDS), and magnetic resonance imaging (MRI) of the brain showed abnormal signal changes in the right parieto-occipital cortex and thalamus, both as yet unreported in cytomegalovirus (CMV) encephalitis, which was diagnosed by the cerebrospinal fluid (CSF) analysis. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Ramanujam, B., Dash, D., Dabla, S., Tripathi, M., Srivastava, M. V. P. Tags: Case Reports Source Type: research

Reducing False-Positive HIV Diagnosis in Niger: A Womens Issue
The entry into both HIV care and secondary prevention is first through the knowledge of one’s own HIV status. Testing for HIV remains challenging in countries where clinicians rely on rapid testing algorithms because the routine use of confirmatory Western blot technology is unavailable. In this case report, we describe the case of a pregnant woman in Niger, who was falsely labeled as HIV positive during prenatal visits. We also describe our clinical algorithm that was developed to facilitate retesting in patients who initially tested HIV positive or indeterminant with rapid diagnostic tests. Vigilance is necessary t...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Simoncini, G. M., Megill, M., van den Berg-Wolf, M. Tags: Case Reports Source Type: research

Severe, Disfiguring, Pityriasis Rubra Pilaris in a Woman in the Dominican Republic: Histopathologic Diagnosis and Response to Antiretroviral Therapy
Pityriasis rubra pilaris (PRP) is a poorly understood dermatologic condition usually accompanied by keratoderma and intense erythroderma with islands of unaffected skin. The PRP categories include HIV-associated PRP VI. A 23-year-old HIV-infected, dark-skinned woman in the Dominican Republic developed an extremely severe, disfiguring process characterized first by a dry scaly rash involving her face, trunk, and extremities with hyperpigmentation and islands of spared skin and minimal erythroderma, followed by alopecia and development of a thick horny layer on the scalp and face. The condition, histologically proven to be P...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - January 4, 2016 Category: Infectious Diseases Authors: Lerebours-Nadal, L., Beck-Sague, C. M., Parker, D., Gosman, A., Saavedra, A., Engel, K., Dean, A. G. Tags: Case Reports Source Type: research