Volumetric-modulated arc therapy (VMAT) versus 3D-conformal radiation therapy in supra-diaphragmatic Hodgkin’s Lymphoma with mediastinal involvement: A dosimetric comparison
Conclusions VMAT is a valuable technique for treatment of large mediastinal HL. VMAT spares the lung and heart compared to 3DCRT using ISRT in select HL cases. VMAT allows dose escalation for post-chemotherapy residual disease with minimal dose to OARs. VMAT low radiation dose (V5) to the normal tissues, and the increased integral dose should be considered. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - May 27, 2016 Category: Cancer & Oncology Source Type: research

Gemcitabine–oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy
Conclusion The GEMOX combination is a regimen with a moderate therapeutic efficacy and tolerable toxic side effects in patients with platinum-resistant EOC. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - May 26, 2016 Category: Cancer & Oncology Source Type: research

Multiple cutaneous metastases in a patient of carcinoma tonsil – Report of a rare case
We present a case of a 55-year-old male with carcinoma tonsil having received concurrent chemo radiotherapy, presenting with multiple cutaneous metastases to the scalp and thigh. To the best of our knowledge, till date only two similar cases of carcinoma tonsil with cutaneous metastasis have been reported in the English literature. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - May 10, 2016 Category: Cancer & Oncology Source Type: research

Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma: The current evidence
Publication date: Available online 6 May 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Rony Benson, Supriya Mallick, P.K. Julka, G.K. Rath Head and neck squamous cell carcinoma (HNSCC) accounts for a large oncologic burden in the developing countries. In patients with locally advanced head and neck cancer multimodality treatment is warranted. Radiation therapy with concurrent chemotherapy has long been considered the standard for patients with disease involving the oropharynx, larynx and hypopharynx. However, addition of chemotherapy to radiotherapy increases treatment related toxicit...
Source: Journal of the Egyptian National Cancer Institute - May 6, 2016 Category: Cancer & Oncology Source Type: research

Hypofractionated Volumetric Modulated Arc Radiotherapy with simultaneous Elective Nodal Irradiation is feasible in prostate cancer patients: A single institution experience
Conclusions Hypo-fractionation dose escalation VMAT–SIB–ENI–WPRT using 2 arcs is a feasible technique for intermediate/high risk OC prostate cancer patients, with acceptable rates of acute/late toxicities, much favorable planning target volume (PTV) coverage, and shorter overall treatment time. Prospective randomized controlled trials are encouraged to confirm its equivalence to other fractionation schemes. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - April 25, 2016 Category: Cancer & Oncology Source Type: research

Role of FDG-PET scan in the management of pediatric mature B cell non-Hodgkin’s lymphoma. CCHE experience
Conclusion PET scan is significantly more sensitive than conventional CT in the management of aggressive pediatric mature B cell NHL. PET negativity is an excellent indicator of tumor response. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - April 25, 2016 Category: Cancer & Oncology Source Type: research

Bleomycin induced flagellate erythema in a patient with thalamic mixed germ cell tumour: Report of a rare adverse effect
Publication date: Available online 19 April 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Ahitagni Biswas, Pramod Kumar Julka Bleomycin induced flagellate dermatitis is an uncommon and unique adverse effect. With the declining use of bleomycin, this complication is becoming increasingly infrequent in day-to-day clinical practice. We herein describe a case of a 13year old male patient with left thalamic mixed germ cell tumour treated by multimodality approach, who developed flagellate erythema after two cycles of combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This ...
Source: Journal of the Egyptian National Cancer Institute - April 19, 2016 Category: Cancer & Oncology Source Type: research

Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in vitro
Conclusion No study involving the effect of aroma/smell on cancer cells has ever been reported before and warrants further investigation on other cancer and normal cell lines. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - April 19, 2016 Category: Cancer & Oncology Source Type: research

Reducing understaging of bladder cancer with the aid of photodynamic cystoscopy
Conclusions Photodynamic cystoscopy is the most efficient diagnostic procedure for flat urothelial lesions and especially for carcinoma in situ. It is significantly more sensitive than conventional white light cystoscopy in Cis diagnosis, thus reducing understaging of the disease and consequently improving recurrence and progression rates. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - April 1, 2016 Category: Cancer & Oncology Source Type: research

Ramucirumab: Boon or bane
Publication date: Available online 26 March 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Priya Tiwari Ramucirumab is the recent addition to the list of monoclonal antibodies being tried in various malignancies. It has been approved in non-small cell lung cancer, gastric cancer and colorectal cancer after progression of one or more lines of therapies in the advanced setting. Though randomized trials have shown benefit, cost effectiveness is questionable. Moreover, the benefits shown are marginal, putting a question mark over its clinical usage. This review summarizes the latest evidence on ...
Source: Journal of the Egyptian National Cancer Institute - March 26, 2016 Category: Cancer & Oncology Source Type: research

Altered fractionation radiotherapy in head and neck squamous cell carcinoma
Conclusion Altered fractionation is a very important treatment schema and requires the reinforcement of its use. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - March 18, 2016 Category: Cancer & Oncology Source Type: research

Broncho-biliary fistula secondary to biliary obstruction and lung abscess in a patient with pancreatic neuro-endocrine tumor
We present a case report of broncho-biliary fistula that developed due to the blockage of biliary stent placed during the management of pancreatic neuroendocrine tumor (pNET); diagnosed on high clinical suspicion, percutaneous cholangiogram and contrast enhanced computed tomography (CECT); and successfully treated with percutaneous transhepatic biliary drainage (PTBD). (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - March 18, 2016 Category: Cancer & Oncology Source Type: research

Management of uveal tract melanoma: A comprehensive review
This article reviews the diagnostic and therapeutic modalities available and thus, can help to individualize the treatment plan for each patient. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - March 12, 2016 Category: Cancer & Oncology Source Type: research

Meckel’s diverticulum complicated with gastro-intestinal stromal tumor: Case report
Conclusion Surgeons and oncologists should bear in mind this rare diagnosis and know how to treat it. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - February 28, 2016 Category: Cancer & Oncology Source Type: research

Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters
Conclusion The level of different adhesion molecules expression in CLL is apparently reflected on the potential migratory behavior of the leukemic cells to different organs. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - February 10, 2016 Category: Cancer & Oncology Source Type: research