External beam radiation techniques for breast cancer in the new millennium: New challenging perspectives
Publication date: Available online 29 August 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Dodul Mondal, Daya Nand Sharma Radiation therapy in breast cancer has evolved dramatically over the past century. It has traveled a long path touching different milestones and taking unprecedented turns. At the end, a fine tune of clinical understanding, skill, technological advancement and translation of radiobiological understanding to clinical outcome has taken place. What all these have given is better survival with quality survivorship. It is thus prudent to understand breast irradiation in a new p...
Source: Journal of the Egyptian National Cancer Institute - August 28, 2016 Category: Cancer & Oncology Source Type: research

Re-irradiation for head and neck squamous cell carcinoma
Conclusion Treatment approaches may have to be personalized. Re surgery must be done in all patients in whom it is feasible. In patients in whom surgery is not feasible, re-irradiation must be evaluated as a therapeutic option especially in patients with limited volume recurrence. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - August 28, 2016 Category: Cancer & Oncology Source Type: research

Management of glioblastoma after recurrence: A changing paradigm
Publication date: Available online 28 July 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Supriya Mallick, Rony Benson, Abdul Hakim, Goura K. Rath Glioblastoma remains the most common primary brain tumor after the age of 40years. Maximal safe surgery followed by adjuvant chemoradiotherapy has remained the standard treatment for glioblastoma (GBM). But recurrence is an inevitable event in the natural history of GBM with most patients experiencing it after 6–9months of primary treatment. Recurrent GBM poses great challenge to manage with no well-defined management protocols. The challe...
Source: Journal of the Egyptian National Cancer Institute - July 28, 2016 Category: Cancer & Oncology Source Type: research

Results of treatment of lymphoblastic lymphoma at the children cancer hospital Egypt – A single center experience
Conclusion Results of treatment of LBL on the St Jude’s total therapy XV study are comparable to most of the similar reported studies. Outcome of relapsing patients is extremely poor, hence there is a need to identify biologic or clinical prognostic factors including minimal residual tumor to better evaluate chemotherapy response. Steroid induced AVN, and cerebral vascular thrombosis were the main chemotherapeutic adverse events. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters
Conclusion In gastric adenocarcinoma, COX-2 expression might serve as a powerful indicator for intestinal type carcinoma, locally advanced disease and H. pylori infection, while VEGF was related to loco-regional progression. COX-2 might be involved in the development of angiogenesis in gastric carcinoma through VEGF upregulation. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Prevalence of hepatocellular carcinoma in chronic hepatitis C patients in Mid Delta, Egypt: A single center study
Conclusion The high prevalence of HCC in our HCV patients (22%) was mainly associated with decompensated cirrhosis. A national surveillance program for the detection of HCC in cirrhotic HCV Egyptian patients by combining ultrasound examination and AFP is highly recommended. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Carcinoma of Gall bladder with distant metastasis to breast parenchyma. Report of a case and review of literature
Conclusion There are limited examples of gall bladder adenocarcinoma with simultaneous metastasis to breast in the English literature. Our case showed an unusual dissemination of gall bladder cancer. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Primary ovarian carcinoid: A report of two cases and a decade registry
Conclusion Primary ovarian carcinoid is a relatively rare disease with an indolent course and excellent outcome. Carcinoid syndrome, especially carcinoid heart disease may worsen the prognosis. Total abdominal hysterectomy with bilateral salpingo-oophorectomy has been commonly used as the treatment of choice of primary ovarian carcinoid tumors. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Phyllodes tumors of the breast: Analysis of 35 cases from a single institution
Conclusion Phyllodes tumors are rare tumors that occur in relatively young women, when compared with the classical adenocarcinoma of the breast. They have a tendency to reach large sizes with absence of nodal metastasis. Although surgery is the mainstay of management, postoperative radiotherapy also appears to decrease the local recurrence rates in certain presentations. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 23, 2016 Category: Cancer & Oncology Source Type: research

Gemcitabine –oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy
Conclusion The GEMOX combination is a regimen with a moderate therapeutic efficacy and tolerable toxic side effects in patients with platinum-resistant EOC. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - June 17, 2016 Category: Cancer & Oncology Source Type: research

Meckel ’s diverticulum complicated with gastro-intestinal stromal tumor: Case report
Conclusion Surgeons and oncologists should bear in mind this rare diagnosis and know how to treat it. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - June 17, 2016 Category: Cancer & Oncology Source Type: research

Role of FDG-PET scan in the management of pediatric mature B cell non-Hodgkin ’s lymphoma. CCHE experience
Conclusion PET scan is significantly more sensitive than conventional CT in the management of aggressive pediatric mature B cell NHL. PET negativity is an excellent indicator of tumor response. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - June 17, 2016 Category: Cancer & Oncology Source Type: research

Preliminary results of robotic colorectal surgery at the National Cancer Institute, Cairo University
Conclusion To the best of our knowledge, this is the first study reporting the outcomes of robotic colorectal cancer intervention in Egyptian patients. Our preliminary results suggest that robotic-assisted surgery for colorectal cancer can be carried out safely and according to oncological principles. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - June 12, 2016 Category: Cancer & Oncology Source Type: research

Porocarcinoma scalp with high risk features treated with surgery and adjuvant radiotherapy: A case report and review of literature
Publication date: Available online 11 June 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Wineeta Melgandi, Rony Benson, Abdul Hakin, Suman Bhasker Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the intra dermal part of the gland and accounts for only 0.005% of all epithelial cutaneous tumors. Commonly involved site includes extremities and face. Scalp is a rare site for porocarcinoma with less than 20 reported cases so far. Wide local excision with clear margins remains the treatment of choice. Review of literature revealed a local recurrence rate of 37.5% an...
Source: Journal of the Egyptian National Cancer Institute - June 10, 2016 Category: Cancer & Oncology Source Type: research

Bacteremia due to ESKAPE pathogens: An emerging problem in cancer patients
Conclusions ESKAPE pathogens were significantly associated with higher rates of morbidity and mortality indicating the need for improving the means of prevention of these types of infections within health care premises. Microbiology laboratories have a role in defining more dangerous infections and rapid diagnostics are required in the era of resistance. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - June 3, 2016 Category: Cancer & Oncology Source Type: research