Radiotherapeutic factors affecting the incidence of developing hypothyroidism after radiotherapy for head and neck squamous cell cancer
ConclusionsThe V30 may predict risk of developing HT after RT for HNSCC patients. V30 of 42.1%, defined as dose-volumetric threshold of radiation-induced HT, can be useful in treatment planning of HNSCC patients. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Reinforcing the utility of chick embryo model to in vivo evaluate engraftment of human leukemic stem cells
ConclusionCollectively, our data confirm the engraftment of primary human CD34+ leukemic cells in chick embryo liver, but other experiments are required to verify engraftment in BM and spleen, and to confirm the identity of a putative CD34 orthologous transcript in these two organs. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Osteosarcoma of the jaw: Challenges in the diagnosis and treatment
ConclusionsOsteosarcoma of the jaw is challenging both to diagnose and manage. This is due to the high incidence of mistakes in biopsy results, rare specific radiological features and difficulties in proper resection due to proximity to vital structures. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

First-line paclitaxel and cisplatin used sequentially or in combination in metastatic breast cancer: A phase II randomized study
ConclusionSequential agent chemotherapy may provide similar response rate and overall survival to combination chemotherapy with much lower toxicities. The former can be considered the standard practice in most instances. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Survival outcome of intermediate risk neuroblastoma at Children Cancer Hospital Egypt
ConclusionA very high rate of survival is currently achievable in patients with intermediate risk neuroblastoma by chemotherapy or chemotherapy and surgery. In addition to response, our plan is to adopt biologically-based treatment to reduce treatment-induced complications among survivors. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Comparative study on the analgesic effect of acute ipsilateral shoulder pain after open thoracotomy between preoperative ultrasound guided suprascapular nerve block (SNB) and intraoperative phrenic nerve infiltration (PNI) in cancer lung patients
ConclusionPNI is more effective than SNB for ISP. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Endometrial carcinoma in a single horn of a bicornuate uterus: A case report
Publication date: June 2018Source: Journal of the Egyptian National Cancer Institute, Volume 30, Issue 2Author(s): Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni ScambiaAbstractWe discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy.The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn s...
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

The role of intraoperative radiotherapy (IORT) in the management of patients with pancreatic and periampullary cancer: A single center experience
ConclusionApplication of IORT is safe and feasible. It can be applied without additional morbidities or mortalities. Although our results are satisfactory, yet they need to be applied on a larger number of patients with longer periods of follow-up to reach sound conclusions. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Estrogen receptor positive breast tumors resist chemotherapy by the overexpression of P53 in Cancer Stem Cells
ConclusionOur results suggest that CSCs in the ER+ cells escape the effect of DOX treatment by the elevation of p53 expression. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Expression of truncated HER2 and its prognostic value in HER2-positive breast cancer patients
ConclusionExpression of p95-HER2 in HER2-positive BC patients is significantly associated with negative hormonal receptors expression, high Ki-67 expression, presence of visceral metastases and worse overall survival. A larger study is required to confirm its association with different prognostic factors and its effect on survival. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Prevalence of lung cancer in Isfahan Province, Iran
ConclusionThe PP for lung cancer in male population was 2.5 times higher than females. There was a 3.2% increase in the Irs over the study period. To facilitate early diagnosis for better management associated to pharmacotherapy or surgical care, our findings emphasized the advantage of further research and greater effort toward environmental, job related exposure, genetic and geographical factors in Isfahan Province/Iran. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

First experience of the Egyptian National Cancer Institute using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer
ConclusionRobotic radical hysterectomy is a feasible approach with a tolerable rate of complications. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Role of hydroxyurea as an adjuvant treatment after Gamma knife radiosurgery for atypical (WHO grade II) meningiomas
Publication date: June 2018Source: Journal of the Egyptian National Cancer Institute, Volume 30, Issue 2Author(s): Khalid Abdel Karim, Amr El Shehaby, Reem Emad, Wael Reda, Manal El Mahdy, Ramy Ghali, Ahmed Nabeel (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Report of a unique case of myoepithelial carcinoma of left parotid gland with metachronous bilateral cavernous sinus metastasis
Publication date: June 2018Source: Journal of the Egyptian National Cancer Institute, Volume 30, Issue 2Author(s): Rambha Pandey, Rituparna Biswas, Mukurdipi Ray, Prashant P. Ramteke, Ekta Dhamija, Anirban HalderAbstractMyoepithelial carcinoma (MC) is a rare, locally aggressive malignant neoplasm of the salivary glands. Only few evidences on its metastatic behavior are available in the literature. We herein present a unique case of MC of left parotid gland which metastasized to bilateral cavernous sinuses. The patient was successfully treated with palliative radiotherapy and chemotherapy. (Source: Journal of the Egyptian N...
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research

Combined percutaneous radiofrequency ablation and cementoplasty for the treatment of extraspinal painful bone metastases: A prospective study
ConclusionCombined radiofrequency ablation and cementoplasty is a safe and effective pain relief modality in patients suffering from extraspinal painful bone metastases with improvement of the quality of life. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - July 5, 2018 Category: Cancer & Oncology Source Type: research