2D QSAR Studies on a Series of substituted purine derivatives inhibitory activity against c-Src tyrosine kinase
Publication date: Available online 21 December 2015 Source:Journal of Taibah University for Science Author(s): Mukesh C. Sharma A Thirty four compounds series of as c-Src tyrosine kinase of substituted purine analogs derivatives were subjected to quantitative structure-activity relationship analyses. Partial least squares regression method was applied to derive QSAR models which were further validated for statistical significance by internal and external validation. The best QSAR model developed gave good predictive correlation coefficient (r2) of 0.8319, significant cross validated correlation coefficient (q2) of 0....
Source: Journal of Taibah University for Science - December 22, 2015 Category: Science Source Type: research

Acoustical and Viscometric studies of Buspirone Hydrochloride drug with Cobalt(II) & Copper(II) metal ions in aqueous medium
Publication date: Available online 21 December 2015 Source:Journal of Taibah University for Science Author(s): Sandeep Tiwari, Brajendra S. Kusmariya, Anjali Tiwari, V. Pathak, A.P. Mishra The measurements of Ultrasonic velocities, densities and viscometric studies have been conducted for Buspirone hydrochloride drug (0.01 to 0.1M) of three different concentration range (0.1, 0.05 and 0.025M) at 298.15K/1atm with aqueous solutions of Cu(II) and Co(II) metal ion. From the obtained experimental data various acoustical parameters such as isentropic compressibility, intermolecular free length, specific acoustic i...
Source: Journal of Taibah University for Science - December 22, 2015 Category: Science Source Type: research

Colorimetric determination of olanzapine via charge transfer complexation with chloranilic acid
Publication date: Available online 19 December 2015 Source:Journal of Taibah University for Science Author(s): Olajire A. Adegoke, Olusegun E. Thomas, Stephen N. Emmanuel The charge-transfer complexation (CTC) formed between olanzapine and chloranilic acid have been studied and used as a sensitive colorimetric method for the determination of olanzapine. Evidence for the formation of the CTC between chloranilic acid (CAA) and olanzapine (OLP) was established by spot tests and TLC. Method development was carried out through selection of analytical wavelength, optimization and validation studies. Physicochemical par...
Source: Journal of Taibah University for Science - December 20, 2015 Category: Science Source Type: research

An Efficient Bound for the Condition Number of the Matrix Exponential
Publication date: Available online 17 December 2015 Source:Journal of Taibah University for Science Author(s): Awad H. Al-Mohy A new bound for the condition number of the matrix exponential is presented. Using the bound, we propose an efficient approximation to the condition number, denoted by κ g (s, X), that avoids the computation of the Fréchet derivative of the matrix exponential that underlies condition number estimation in the existing algorithms. We exploit the identity e X = ( e X / 2 s ) 2 s for a nonnegative integer s with the properties of the Fréchet derivative operator to obtain the...
Source: Journal of Taibah University for Science - December 18, 2015 Category: Science Source Type: research

Dual-wave β-correction spectrophotometric determination of palladium ions using neothorin
Publication date: January 2016 Source:Journal of Taibah University for Science, Volume 10, Issue 1 Author(s): Eman A. Al-Harbi A simple low cost method has been developed and validated for the determination of trace amounts of palladium (II) ions in water and fertilizer samples. The method is based on the reaction of palladium (II) ions with the reagent neothorin (2-(2-arsonophenylazo) chromotropic acid disodium salt). The complex formed exhibits an absorption maximum at 567nm (λ max) in Britton–Robinson (BR) buffer (pH=2). The corrected absorbance of the formed complex at λ max was obtained by employing a β-cor...
Source: Journal of Taibah University for Science - December 12, 2015 Category: Science Source Type: research

Global minima of iron clusters described by gupta potential
Publication date: Available online 2 December 2015 Source:Journal of Taibah University for Science Author(s): S. Nouemo, F. Tchoffo, J.M.B. Ndjaka, S. Domngang In this paper, we present global minimum energy for iron clusters, ranging from with sizes N=2 to 100 atoms, described by the phenomenological Gupta potential. Our optimized structures and symmetry groups are in agreement with previous ones obtained using Finnis-Sinclair potential; but our energy levels and nearest neighbor distances differ slightly. The origins of the differences are related back to the differences in the potentials (Source: Journal of ...
Source: Journal of Taibah University for Science - December 3, 2015 Category: Science Source Type: research

Validation of new mathematical formulae for calculating the well-type gamma-ray detector efficiencies
Publication date: Available online 30 November 2015 Source:Journal of Taibah University for Science Author(s): Eman. M. El-Bayoumi, N.S. Aly, Mahmoud I. Abbas In this work direct mathematical formulae for measuring the full-energy peak efficiency of HPGe well-type detector are found and the value of the measured efficiencies are compared with the published works of the experimental and theoretical old method and having a good agreement. In this new approach the path length d(θ, ϕ) is derived as a function in the polar angle θ, and the azimuthal angle ϕ. This will reduce the mathematical formulae to an easiest...
Source: Journal of Taibah University for Science - December 1, 2015 Category: Science Source Type: research

Synthesis, growth, and structural, optical, mechanical, electrical properties of a new inorganic nonlinear optical crystal: Sodium manganese tetrachloride (SMTC)
Publication date: Available online 10 November 2015 Source:Journal of Taibah University for Science Author(s): M. Packiya raj, S.M. Ravi Kumar, R. Srineevasan, R. Ravisankar A new inorganic nonlinear optical single crystal of sodium manganese tetrachloride (SMTC) has been successfully grown from aqueous solution using the slow evaporation technique at room temperature. The crystals obtained using the aforementioned method were characterized using different techniques. The crystalline nature of the as-grown crystal of SMTC was analyzed using powder X-ray diffraction. Single-crystal X-ray diffraction revealed tha...
Source: Journal of Taibah University for Science - November 30, 2015 Category: Science Source Type: research

Production of biogas from poultry litter mixed with the co-substrate cow dung
Publication date: Available online 6 November 2015 Source:Journal of Taibah University for Science Author(s): Mohammad Roman Miah, Abul Kalam Md. Lutfor Rahman, Muhammad Rajibul Akanda, Abdullah Pulak, Md. Abdur Rouf Poultry litter (a mixture of rice hulls, sawdust and chicken excreta of broilers) mixed with the co-substrate cow dung and poultry droppings was evaluated under anaerobic conditions for the production of biogas (methane). Four laboratory scale reactors, R1, R2, R3 and R4, were set up with different proportions of waste poultry litter, cow dung and poultry droppings and had a 6% total solid concen...
Source: Journal of Taibah University for Science - November 28, 2015 Category: Science Source Type: research

Assessment of Natural Radioactivity in Fertilizers and Phosphate Ores in Egypt
Publication date: Available online 27 November 2015 Source:Journal of Taibah University for Science Author(s): Nabil M. Hassan, Nassif A. Mansour, Mohamed Fayez-Hassan, Ebrahim Sedqy Radionuclides concentrations of uranium (238U), thorium (232Th) and potassium (40K) maintained in 10 phosphate ores and 5 fertilizers samples were measured using high-purity germanium detector. The concentrations of these radionuclides in phosphate ores samples were relatively high for 226Ra of 871.37±91.90Bqkg−1 and relatively low for 232Th, and 40K of 19.21±2.42Bqkg−1 and 176.06±17.66Bqkg−1, respectively. These radionucl...
Source: Journal of Taibah University for Science - November 28, 2015 Category: Science Source Type: research

Kinetics and deactivation of a dual sites heterogeneous oxide catalyst during transesterification of crude Jatropha oil with methanol
Publication date: Available online 27 November 2015 Source:Journal of Taibah University for Science Author(s): M.A. Olutoye, B.H. Hameed In this work, dual sites heterogeneous catalyst was used to study the kinetics of transesterification of crude jatropha oil with methanol in batch experiments. Experimental data were obtained between 150 and 182°C at constant molar ratio of alcohol to oil (11:1) and at concentration of catalyst (3.32 wt% based on weight of oil). Kinetic modeling was performed with assumed pseudo-first order to describe the rate and catalyst deactivation. This was found to suitably fit the experim...
Source: Journal of Taibah University for Science - November 28, 2015 Category: Science Source Type: research

LC–MS/MS characterization of the forced degradation products of ezetemibe: Development and validation of a stability-indicating UPLC method
Publication date: Available online 10 November 2015 Source:Journal of Taibah University for Science Author(s): Prasad Kancherla, Venkatappaiah Velpuri, Pallavi Alegete, Saeed S. Albaseer, Mukkanti Khagga, Parthasaradhi Das The present study reports the characterization of four degradation products from ezetemibe (EZB) through liquid chromatography–tandem mass spectrometry (LC–MS/MS) and the development of a validated and stability-indicating reversed-phase ultra-performance liquid chromatographic method for the determination of EZB in the presence of its process-related impurities in bulk drugs. The for...
Source: Journal of Taibah University for Science - November 27, 2015 Category: Science Source Type: research

Support vectors machines for modeling the phosphocalcic hydroxyapatite by precipitation from a calcium carbonate solution and phosphoric acid solution
Publication date: Available online 12 November 2015 Source:Journal of Taibah University for Science Author(s): Houda Labjar, Walid Cherif, Salah Nadir, Khalid Digua, Brahim Sallek, Hassan Chaair The aim of this work has been to develop an effective quantitative relationships model, using support vector machines, for the synthesis of the phosphocalcic hydroxyapatite by precipitation from a calcium carbonate solution and a phosphoric acid solution. The model was performed using a set of factors consisting of the pH of the reactional solution, the Ca/P molar ratio of reagents, the reaction time and the initial...
Source: Journal of Taibah University for Science - November 13, 2015 Category: Science Source Type: research

LC-MS/MS characterization of the forced degradation products of ezetemibe: Development and validation of a stability-indicating UPLC method
Publication date: Available online 10 November 2015 Source:Journal of Taibah University for Science Author(s): Prasad Kancherla, Venkatappaiah Velpuri, Pallavi Alegete, Saeed. S. Albaseer, Mukkanti Khagga, Parthasaradhi Das The present study reports the characterization of four degradation products from ezetemibe (EZB) through liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the development of a validated and stability-indicating reversed-phase ultra-performance liquid chromatographic method for the determination of EZB in the presence of its process-related impurities in bulk drugs. The forced...
Source: Journal of Taibah University for Science - November 11, 2015 Category: Science Source Type: research

A new catalyst for the synthesis of 2-substituted perimidines catalyzed by FePO4
Publication date: Available online 10 November 2015 Source:Journal of Taibah University for Science Author(s): F.K. Behbahani, Fatemeh M. Golchin The reaction of 1,8-diaminonaphthalene with aromatic aldehydes gave 2-substituted perimidines in the presence of FePO4 as a versatile, green and reusable catalyst at room temperature respectively Graphical abstract (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - November 11, 2015 Category: Science Source Type: research