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Simultaneous analysis of aliskiren and hydrochlorothiazide in pharmaceutical preparations and spiked human plasma by HPTLC
Publication date: Available online 13 May 2016 Source:Journal of Taibah University for Science Author(s): Jui J. Pandya, Nejal M. Bhatt, Vijay D. Chavada, Primal Sharma, Mallika Sanyal, Pranav S. Shrivastav A simple, selective and precise method based on HPTLC has been developed for the simultaneous determination of aliskiren and hydrochlorothiazide in a fixed-dose tablet formulation and human plasma. The chromatography was performed on silica gel 60 GF254 plates, with a mobile phase consisting of methanol–chloroform (6:4, v/v). Densitometric analysis of the analytes was carried out at 225nm. Under optimi...
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research

Determination of trace amounts of Brown HT as a food dye by a CPE-scanometry method
In this study, trace amounts of Brown HT were extracted, pre-concentrated and determined by cloud point extraction-scanometry (CPE-scanometry) as a simple, fast and inexpensive method. The procedure is based on CPE of Brown HT from an aqueous solution, diluting the extracted surfactant-rich phase with ethanol to 500μL, transferring the appropriate volume to Plexiglas® cells and scanning the cells. Then, the colour of each cell was analyzed by software written in visual basic (VB 6) into red, green and blue values. Effective parameters for the extraction efficiency, such as the pH of the system, the concentration of surfa...
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research

QSAR study and molecular docking of benzimidazole derivatives as potent activators of AMP-activated protein kinase
Publication date: Available online 3 June 2016 Source:Journal of Taibah University for Science Author(s): Nidal Naceiri Mrabti, Menana Elhallaoui 3D-QSAR and molecular docking methods were performed on a set of 74 benzimidazole derivatives previously studied as activators of the AMP-activated protein kinase (AMPK), a protein that plays a key role in the regulation of cellular energy balance. Relative enzyme activity (REA) of 74 compounds was quantitatively modelled using multiple linear regression (MLR) and neuronal networks (NN). The proposed QSAR model provided statistically significant results (r MLR =0.89; r NN...
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research

Biogenic synthesis of silver nanoparticles using a pod extract of Cola nitida: Antibacterial and antioxidant activities and application as a paint additive
This study has demonstrated the biogenic synthesis of AgNPs that have potent antimicrobial and antioxidant activities and potential biomedical and industrial applications. To the best of our knowledge, this work is the first to use the pod extract of C. nitida for the green synthesis of nanoparticles. (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research

The inhibitory activity of aldose reductase of flavonoid compounds: Combining DFT and QSAR calculations
This study shows that the MLR and MNLR predict activity, but compared to the results of the ANN model, we conclude that the predictions achieved by the latter are more effective and better than the other models. The results indicate that the ANN model is statistically significant and shows very good stability toward data variation for the validation method. The contribution of each descriptor to the structure–activity relationship was also evaluated. (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research

Water body extraction and change detection using time series: A case study of Lake Burdur, Turkey
In this study, spatiotemporal changes in Lake Burdur from 1987 to 2011 were evaluated using multi-temporal Landsat TM and ETM+ images. Support Vector Machine (SVM) classification and spectral water indexing, including the Normalized Difference Water Index (NDWI), Modified NDWI (MNDWI) and Automated Water Extraction Index (AWEI), were used for extraction of surface water from image data. The spectral and spatial performance of each classifier was compared using Pearson's r, the Structural Similarity Index Measure (SSIM) and the Root Mean Square Error (RMSE). The accuracies of the SVM and satellite-derived indexes were teste...
Source: Journal of Taibah University for Science - June 17, 2016 Category: Science Source Type: research

Modelling the cytotoxic activity of pyrazolo-triazole hybrids using descriptors calculated from the open source tool “PaDEL-descriptor”
In this study, we developed QSAR models for the anti-proliferative activity of pyrazolo-triazole hybrids [(1-benzyl-1H-1,2,3-triazol-4-yl)(1,3-diphenyl-1H-pyrazol-4-yl) methanone] on human brain cancer (U87MG), lung cancer (A549), prostate cancer (PC-3), and colon cancer (HT-29) cell lines. We employed K-means cluster analysis to split the data sets. Statistically robust models were generated [ pIC 50 (U87MG): R =0.873, Q 2 =0.554, R p r e d 2 = 0.866 ; pIC 50 (A549): R =0.879, Q 2 =0.637, R p r e d 2 = 0.858 ; pIC 50 (PC3): R =0.953; Q 2 =0.850; R p r e d 2 = 0.796 ; pIC 50 (HT-29): ...
Source: Journal of Taibah University for Science - June 16, 2016 Category: Science Source Type: research

Shifted Legendre method with residual error estimation for delay linear Fredholm integro-differential equations
Publication date: Available online 11 April 2016 Source:Journal of Taibah University for Science Author(s): Şuayip Yüzbaşı In this paper, we suggest a matrix method for obtaining the approximate solutions of the delay linear Fredholm integro-differential equations with constant coefficients using the shifted Legendre polynomials. The problem is considered with mixed conditions. Using the required matrix operations, the delay linear Fredholm integro-differential equation is transformed into a matrix equation. Additionally, error analysis for the method is presented using the residual function. Illustrative example...
Source: Journal of Taibah University for Science - June 14, 2016 Category: Science Source Type: research

3D-QSAR Models to Predict Anti-Cancer Activity on a Series of Protein P38 MAP Kinase Inhibitors
In this study, three-dimensional quantitative structure-activity relationship (3D-QSAR) analyses, including Multiple Linear Regression (MLR), Partial Least Squares (PLS), Multiple Non-Linear Regression (MNLR), Artificial Neural Network (ANN) and cross-validation analyses, were performed on a set of P38 MAP kinases as anti-cancer agents. This method, which is based on molecular modeling (molecular mechanics, HF), was used to determine the structural parameters, electronic properties, and energy associated with the molecules we examined. MLR, PLS, and MNLR analyses were performed on 46 protein P38 MAP kinase analogues to det...
Source: Journal of Taibah University for Science - June 14, 2016 Category: Science Source Type: research

Artichoke as a non-conventional precursor for activated carbon: Role of the activation process
Publication date: Available online 3 June 2016 Source:Journal of Taibah University for Science Author(s): Gamal M.S. ElShafei, Ibrahim M.A. ElSherbiny, Atef S. Darwish, Christine A. Philip Artichoke peels were used to produce activated carbon using chemical activation methods. Two activation protocols were compared: a two-step method A and a one-step method B. As newly used activating agents, KCl, CrCl3 and TiCl4 were compared. The results show that method B is superior to A. KOH with method B had an area of 2321m2/g and a total pore volume 1.0071cm3/g, of which 0.9794cm3/g was confined to micropores. The corre...
Source: Journal of Taibah University for Science - June 3, 2016 Category: Science Source Type: research

QSAR study and molecular Docking of benzimidazole derivatives as potent AMP-Activated protein Kinase activators
Publication date: Available online 3 June 2016 Source:Journal of Taibah University for Science Author(s): Nidal Naceiri Mrabti, Mennana El Hallaoui 3D-QSAR and Molecular Docking methods were performed on a set of 74 benzimidazole derivatives considered as activators of the AMP-activated protein Kinase (AMPK) that plays a key role in the regulation of cellular energy balance. Relative Enzyme Activity (REA) of 74 compounds is quantitatively modeled by using Multiple Linear Regression (MLR), and Neuronal Networks (NN). The proposed QSAR model has provided statistically significant results (rMLR = 0,89; rNN =0.95 and r...
Source: Journal of Taibah University for Science - June 3, 2016 Category: Science Source Type: research

Study of Natural Radioactivity in Lake Miri in South West of Sudan
Publication date: Available online 30 May 2016 Source:Journal of Taibah University for Science Author(s): Magdi Hassan Saad The focus of this study is to investigate the suitability of Lake Miri, a place of high natural radioactivity in the south west of Sudan as water source for nearby villages. Soil, water, foodstuffs and vegetable samples were collected and analyzed. The results show that the mean natural radioactivity level in the study area in average is 450 nGy/hr which is ten times greater than other places in Sudan with normal quantity (40 nGy/hr) natural radioactivity, and that the average annual exposure of...
Source: Journal of Taibah University for Science - May 30, 2016 Category: Science Source Type: research

A new technical for solving a weakly singular integro-differential equations
Publication date: Available online 27 May 2016 Source:Journal of Taibah University for Science Author(s): Mostefa Nadir In this work, we transform a weakly singular integro-differential equations with logarithmic kernel to singular integral equations of Cauchy type and we prove by regularization the existence and uniqueness of the the solution of this equations. Numerical examples illustrate the effectiveness of this new technical methods. (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - May 27, 2016 Category: Science Source Type: research

Analysis of projectile motion with quadratic air resistance from a nonzero height using the Lambert W function
Publication date: Available online 4 March 2016 Source:Journal of Taibah University for Science Author(s): Chokri Hadj Belgacem Using the Lambert W function, the quadratic resisted projectile motion with an approximation of low-angle trajectory has been studied where the launching point is assumed to be higher than the landing point. Analytical solutions for the range and the time of flight are presented in terms of the secondary branch of the Lambert function W −1. (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - May 26, 2016 Category: Science Source Type: research

viscoelastoplastic bodies Under Cyclic loading in thermal-radiation fields
This study considers the process of a combined effect of the heat, radiation and force cyclic loads on a viscoelastoplastic laminated body within the frames of the theory of small elastoplastic deformations. (Source: Journal of Taibah University for Science)
Source: Journal of Taibah University for Science - May 26, 2016 Category: Science Source Type: research