Natural hydrogels for cartilage regeneration: Modification, preparation and application
Publication date: Available online 14 October 2018Source: Journal of Orthopaedic TranslationAuthor(s): Lan Li, Fei Yu, Liming Zheng, Rongliang Wang, Wenqiang Yan, Zixu Wang, Jia Xu, Jianxiang Wu, Dongquan Shi, Liya Zhu, Xingsong Wang, Qing JiangAbstractHydrogels, consisting of hydrophilic polymers, can be used as films, scaffolds, nanoparticles and drug carriers. They are one of the hot research topics in material science and tissue engineering and are widely used in the field of biomedical and biological sciences. Researchers are seeking for a type of material that is similar to human tissues and can partially replace hu...
Source: Journal of Orthopaedic Translation - October 14, 2018 Category: Orthopaedics Source Type: research
Discrimination of vertebral fragility fracture with lumbar spine bone mineral density measured by quantitative computed tomography
ConclusionThis study suggests that BMD is closely related to vertebral fragility fracture and that QCT is an effective technique to accurately discriminate vertebral fragility fracture.The translational potential of this articleThe spine BMD measured by QCT is closely related to fracture, which may allow clinicians to more accurately discriminate which individuals are likely to experience vertebral fragility fracture. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 10, 2018 Category: Orthopaedics Source Type: research
Effectiveness of biceps tenodesis VS SLAP repair for surgical treatment of isolated SLAP lesions: A systemic review and meta-analysis
ConclusionsBoth the surgical treatments, SLAP repair and the biceps tenodesis, are efficacious in pain alleviation and recovery of shoulder function. But, compared with SLAP repair, biceps tenodesis showed higher rate of patient satisfaction and return to preinjury sports participation.The translational potential of this articleImpart better understanding regarding discrepancies in the outcomes between biceps tenodesis and SLAP repair in treating patients with isolated Type II SLAP lesions. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 5, 2018 Category: Orthopaedics Source Type: research
Surface treatment strategies to combat implant-related infection from the beginning
Publication date: Available online 28 September 2018Source: Journal of Orthopaedic TranslationAuthor(s): Minqi Wang, Tingting TangAbstractOrthopaedic implants are recognised as important therapeutic devices in the successful clinical management of a wide range of orthopaedic conditions. However, implant-related infections remain a challenging and not uncommon issue in patients with implanted instrumentation or medical devices. Bacterial adhesion and formation of biofilm on the surface of the implant represent important processes towards progression of infection. Given the intimate association between infection and the impl...
Source: Journal of Orthopaedic Translation - October 5, 2018 Category: Orthopaedics Source Type: research
Usefulness of conventional magnetic resonance imaging, diffusion tensor imaging and neurite orientation dispersion and density imaging in evaluating postoperative function in patients with cervical spondylotic myelopathy
ConclusionConventional magnetic resonance imaging signs could be considered as a reference to make an approximate assessment, whereas DTI and NODDI could be better quantitative tools for evaluating the postoperative function and may help in interpreting residual symptoms.The translational potential of this articleDTI and NODDI could provide reliable postoperative evaluation and analysis for cervical spondylotic myelopathy patients. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 16, 2018 Category: Orthopaedics Source Type: research
Biomechanical properties of novel transpedicular transdiscal screw fixation with interbody arthrodesis technique in lumbar spine: A finite element study
ConclusionBoth BPSS and TPTD can provide stable biomechanical properties for lumbar spine. The decreased ROM of flexion, extension and lateral bending was slightly more in BPSS model than in TPTD model, but TPTD model had similar ROM of axial rotation with BPSS model. The screws' peak stress of TPTD screw focused on the L4–L5 intervertebral space region, and more caution should be put at this site for the fatigue breakage. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 11, 2018 Category: Orthopaedics Source Type: research
Articular cartilage regeneration using acellular bioactive affinity-binding alginate hydrogel: A 6-month study in a mini-pig model of osteochondral defects
ConclusionsThe treatment with acellular injectable growth factor–loaded affinity-binding alginate hydrogel resulted in effective tissue restoration with major hallmarks of hyaline cartilage, shown in large animal model after 6-month follow-up.The translational potential of this articleThis proof-of-concept study in a clinically relevant large animal model showed promising potential of an injectable acellular growth factor–loaded affinity-binding alginate hydrogel for effective repair and regeneration of articular hyaline cartilage, representing a strong candidate for future clinical development. (Source: Journal of Ort...
Source: Journal of Orthopaedic Translation - September 10, 2018 Category: Orthopaedics Source Type: research
Osteoporotic vertebral endplate and cortex fractures: A pictorial review
This article aims to serve as a teaching material for radiologists/physicians or researchers to evaluate osteoporotic ECF. Emphasis is particularly dedicated to identifying ECF that may not be associated with apparent vertebral body collapse. We suggest a combined approach based on standardised radiologic evaluation by experts, and morphometry measurement is the most appropriate approach to detect and classify osteoporotic vertebral fractures. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 6, 2018 Category: Orthopaedics Source Type: research
Functional outcomes and quality of life in adult ipsilateral femur and tibia fractures
Publication date: Available online 5 September 2018Source: Journal of Orthopaedic TranslationAuthor(s): Abdullah Demirtas, Ibrahim Azboy, Celil Alemdar, Mehmet Gem, Emin Ozkul, Mehmet Bulut, Kadir Uzel (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 5, 2018 Category: Orthopaedics Source Type: research
Application of ultrasound accelerates the decalcification process of bone matrix without affecting histological and immunohistochemical analysis
ConclusionThe application of US decalcification significantly shortened the decalcification time in EDTA without causing histological artefacts.The translational potential of this articleThis article shows that the application of ultrasound in sample decalcification would shorten the duration that decalcification required. This would accelerate the sample processing for routine bone histology in both basic and clinical research and assessments for diagnostic purposes. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 5, 2018 Category: Orthopaedics Source Type: research
Informed appropriate imaging for low back pain management: A narrative review
Publication date: Available online 27 August 2018Source: Journal of Orthopaedic TranslationAuthor(s): Yì Xiáng J. Wáng, Ai-Min Wu, Fernando Ruiz Santiago, Marcello H. Nogueira-BarbosaAbstractMost patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have had up to 6 weeks of medical management and physical therapy that resulted in little or no improvement in their LBP. It is also considered for those patients presenting with suspicion for serious ...
Source: Journal of Orthopaedic Translation - August 28, 2018 Category: Orthopaedics Source Type: research
Disc degeneration promotes regional inhomogeneity in the trabecular morphology of loaded rat tail vertebrae
ConclusionDisc degeneration promotes regional inhomogeneity in the vertebral trabecular morphology, with the convex region of the vertebrae having the worse trabecular bone morphology than the concave region.The translational potential of this article:Our study indicates that disc degeneration promotes regional inhomogeneity in the vertebral trabecular morphology. Regional variations in trabecular microarchitecture are helpful to predict vertebral fragility. This may help to elucidate the mechanisms by which disc degeneration contributes to vertebral fracture. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 23, 2018 Category: Orthopaedics Source Type: research
Association between Modic changes and endplate sclerosis: Evidence from a clinical radiology study and a rabbit model
ConclusionSclerosis can occur in endplates with any type of MCs. However, the clinical and animal study suggests that sclerosis is greatest in endplates showing type III MCs.The translational potential of this articleThe study showed that sclerosis can occur in endplates with MCs type I, II and III. In patients with endplate sclerosis on plain radiographs or CT scans, the endplate can still represent an inflammatory process associated with chronic lower back pain. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 17, 2018 Category: Orthopaedics Source Type: research
Use of a three-dimensional printed polylactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits
ConclusionOur new PPS composite scaffold may be an excellent orthopaedic substitute; it exhibits good biocompatibility and may potentially have clinical utility.Translational potential of this articleMagnesium and beta-tricalcium phosphate had osteoinduction. It is significant to print a novel bone composite scaffold with osteoinduction to repair segmental bone defects. This study evaluated efficacy of PPS in the rabbit radius segmental bone defect model. The results showed that the novel scaffold with good biocompatibility may be an excellent graft and potentially have clinical utility. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 17, 2018 Category: Orthopaedics Source Type: research
All osteoporotically deformed vertebrae with >34% height loss have radiographically identifiable endplate/cortex fracture
Publication date: July 2018Source: Journal of Orthopaedic Translation, Volume 14Author(s): Min Deng, Timothy C.Y. Kwok, Jason C.S. Leung, Ping Chung Leung, Yì Xiáng J. Wáng (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 10, 2018 Category: Orthopaedics Source Type: research
