Quantitative ultrasound imaging monitoring progressive disuse osteopenia and mechanical stimulation mitigation in calcaneus region through a 90-day bed rest human study
This study evaluates the longitudinal effect of a dynamic mechanical loading through the heel on human bone in vivo during 90-day bed rest, monitored by quantitative ultrasound (QUS) imaging and dual-energy X-ray absorptiometry (DXA) in localized regions of interests, i.e., calcaneus. A total of 29 bed rest individuals were evaluated (11 control and 18 treatment) with a brief (15-min) daily low-intensity (0.3 gg), high-frequency (30 Hz) dynamic mechanical stimulation countermeasure through vibrational inhibition of bone erosion (VIBE). Both QUS and DXA detected longitudinal bone density and quality changes. Ultrasound ve...
Source: Journal of Orthopaedic Translation - December 25, 2018 Category: Orthopaedics Source Type: research
A novel method for estimating nail-tract bone density for intertrochanteric fractures
ConclusionsThe proposed method is reproducible for determining the average vBMD, which may provide a reference index for selection of appropriate intramedullary nails for individual patients. The current choice of intramedullary nail based on the experience of a surgeon may be biased.The translational potential of this articleA novel method was proposed to measure the spatial average vBMD of nail tracts, which has good potential to provide a reference index for surgeons to choose appropriate implants. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 22, 2018 Category: Orthopaedics Source Type: research
Huo Xue Tong Luo capsule, a vasoactive herbal formula prevents progression of asymptomatic osteonecrosis of femoral head: A prospective study
ConclusionAs an agent formulated by vasoactive herbals, HXTL capsule with specific protocol is an effective medicine for relieving hip pain and preventing joint collapse in patients with asymptomatic ONFH.The translational potential of this articleThe translation potential of this prospective cohort study is that the initially officially approved clinical indication for HXTL capsule for treatment of ONFH is due to its possible effect of revascularization on angiogenesis of necrosis. It is has been now proven to be effective for a new clinical application. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 22, 2018 Category: Orthopaedics Source Type: research
Discordance in diagnosis of osteoporosis by quantitative computed tomography and dual-energy X-ray absorptiometry in Chinese elderly men
ConclusionOur study demonstrated that discordance was common when using QCT and DXA to diagnose osteoporosis and that spinal degeneration, aorta calcification and fracture obscure the bone mineral density measurement of spine by DXA. QCT is a more sensitive method of choice to identify osteoporosis in elderly Chinese men.The translational potential of this articleThis study investigated the diagnostic discordance of osteoporosis by quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) in Chinese elderly men. The results demonstrated that QCT is a more sensitive method of choice to identify oste...
Source: Journal of Orthopaedic Translation - December 22, 2018 Category: Orthopaedics Source Type: research
The correlation between activity level, serum-ion concentrations and pseudotumours in patients with metal-on-metal hip articulations and metal-on-polyethylene total hip articulations
ConclusionThe daily PA level of patients who underwent MoM THA/RHA influences the serum-ion concentrations of chromium and cobalt and the risk of pseudotumour formation.Translational potential of this articleResults of this article add important knowledge on potential recommendations of prosthesis selection for patients with a high level of physical activity. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 18, 2018 Category: Orthopaedics Source Type: research
Orthopaedic imaging for translational research and clinical application
Publication date: October 2018Source: Journal of Orthopaedic Translation, Volume 15Author(s): Xiao-Guang Cheng, Yi Xiang J. Wang (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 30, 2018 Category: Orthopaedics Source Type: research
Agreement in component size between preoperative measurement, navigation and final implant in total knee replacement
ConclusionsThe high level of agreement found in component sizes between radiographic measurement with digitized templates and navigation suggests that preoperative X-ray measurement is not needed when navigation is used for placement of implants during TKR.The translational potential of this articleComputer-assisted surgery may avoid preoperative measurement with templates in TKR. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 24, 2018 Category: Orthopaedics Source Type: research
Biomechanical comparison between standard and inclined screw orientation in dynamic hip screw side-plate fixation: The lift-off phenomenon
Publication date: Available online 17 November 2018Source: Journal of Orthopaedic TranslationAuthor(s): Ivan Zderic, Gaston C. Willhuber, Marc-Daniel Ahrend, Florian Gras, Jorge Barla, Carlos Sancineto, Markus Windolf, Boyko GueorguievAbstractBackgroundCommon failure modes of dynamic hip screw are cut-out and lift-off. To minimize the latter, distal screws can be inserted in different orientation. However, the effectiveness remains controversial. The aim of the study was to biomechanically investigate the influence of distal screw orientation on construct stability.MethodsThirty artificial generic long bones were assigned ...
Source: Journal of Orthopaedic Translation - November 18, 2018 Category: Orthopaedics Source Type: research
Giant cell tumour of the bone treated with denosumab: How has the blood supply and oncological prognosis of the tumour changed?
ConclusionDenosumab treatment can reduce the blood supply of giant cell tumour. The sacral or pelvic lesions changed more significantly than limb lesions. The surgical plan downstaging can also be achieved. The clear margin after denosumab treatment facilitated tumour resection but, increased difficult in curettage surgery, and high recurrence rate of sacral tumour is being concerned. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 8, 2018 Category: Orthopaedics Source Type: research
Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial
ConclusionsWe found COX-2 inhibitor to be safe and effective for the treatment of PHO in our cohort.The translational potential of this article: The underlying genes responsible for PHO suggest COX inhibitor as potential therapy, and our study demonstrates the efficacy and safety of this treatment. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 1, 2018 Category: Orthopaedics Source Type: research
Magnetic resonance imaging features for the differential diagnosis of local recurrence of bone sarcoma after prosthesis replacement
ConclusionsFor the post-operative MRI surveillance of oncological orthopaedic surgery with prosthesis reconstruction, a mass larger than 2.1 cm was highly specific for recurrence. When a mass was smaller than 2.1 cm, more solid property, more adjacent tissue infiltration, and less muscular oedema indicated recurrence rather than a benign mass.The translational potential of this articleThere has been very little data associated with the post-operative magnetic resonance imaging features indicating recurrence in patients with malignant bone sarcoma after prosthesis replacement. This study could help develop diagnostic feat...
Source: Journal of Orthopaedic Translation - October 30, 2018 Category: Orthopaedics Source Type: research
Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
Publication date: Available online 28 October 2018Source: Journal of Orthopaedic TranslationAuthor(s): Klaus Engelke, Oleg Museyko, Ling Wang, Jean-Denis LaredoAbstractThe radiological assessment of muscle properties—size, mass, density (also termed radiodensity), composition, and adipose tissue infiltration—is fundamental in muscle diseases. More recently, it also became obvious that muscle atrophy, also termed muscle wasting, is caused by or associated with many other diseases or conditions, such as inactivity, malnutrition, chronic obstructive pulmonary disorder, cancer-associated cachexia, diabetes, renal and cardi...
Source: Journal of Orthopaedic Translation - October 29, 2018 Category: Orthopaedics Source Type: research
Spinal phantom comparability study of Cobb angle measurement of scoliosis using digital radiographic imaging
Publication date: Available online 26 October 2018Source: Journal of Orthopaedic TranslationAuthor(s): Ni Chung, Yi-Hong Cheng, Hiu-Lam Po, Wai-Kit Ng, Kam-Ching Cheung, Ho-Yin Yung, Yau-Ming Lai (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 26, 2018 Category: Orthopaedics Source Type: research
Effectiveness of biceps tenodesis versus SLAP repair for surgical treatment of isolated SLAP lesions: A systemic review and meta-analysis
ConclusionsBoth the surgical treatments, SLAP repair and the biceps tenodesis, are efficacious in pain alleviation and recovery of shoulder function. But, compared with SLAP repair, biceps tenodesis showed higher rate of patient satisfaction and return to preinjury sports participation.The translational potential of this articleImpart better understanding regarding discrepancies in the outcomes between biceps tenodesis and SLAP repair in treating patients with isolated Type II SLAP lesions. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 17, 2018 Category: Orthopaedics Source Type: research
Effectiveness of intravenous acetaminophen for postoperative pain management in shoulder arthroplasties: A population-based study
ConclusionIn this first large-scale study that assesses IV APAP in shoulder arthroplasties, IV APAP use was not associated with decreased opioid utilization or the length/cost of stay. These results do not support routine use of IV APAP in this cohort, especially given its high cost. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 16, 2018 Category: Orthopaedics Source Type: research
