Restoration of osteochondral defects by implanting bilayered poly(lactide-co-glycolide) porous scaffolds in rabbit joints for 12 and 24 weeks
ConclusionsOur bilayered PLGA porous scaffold supports long-term osteochondral repair via in vivo tissue engineering or regeneration, and its effect can be further facilitated under the scaffold seeded with allogenic BMSCs.The translational potential of this articleThe bilayered PLGA porous scaffold can facilitate the repair of osteochondral defects and has potential for application in osteochondral tissue engineering. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - May 18, 2019 Category: Orthopaedics Source Type: research
Computed tomography perfusion study evaluating the curative effect of tibial transverse transport in patients with severe diabetic foot
ConclusionThere were significant differences in relative BV, relative mean transit time, and ST between the two groups before and after surgery, and the postoperative BV in the NTF group and ST values in the two groups were increased compared with the preoperative values. The BV in the NTF group and the ST values in the two groups were effective indicators in evaluating the changes between preoperative and postoperative perfusion. These results indicate that TTT could increase plantar tissue perfusion as assessed by BV and ST; this increase was among the reasons for the surface healing of severe DF ulcers. (Source: Journal...
Source: Journal of Orthopaedic Translation - May 14, 2019 Category: Orthopaedics Source Type: research
Surface degradation–enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement
ConclusionsThis work validates a new concept of designing bioactive bone/implant interface with desirable properties. And this novel bone cement possesses great potential for minimally invasive orthopaedic surgeries such as percutaneous kyphoplasty.The translational potential of this articleThis work reports PMMA/Mg surface-degradable acrylic bone cements that possess enhanced osseointegrative, angiogenic and antiinfective properties that are lacking in the clinically used acrylic bone cements. This new kind of bone cements could improve the treatment outcome of many orthopaedic surgeries such as percutaneous kyphoplasty a...
Source: Journal of Orthopaedic Translation - May 9, 2019 Category: Orthopaedics Source Type: research
Polydopamine-assisted surface modification for orthopaedic implants
Publication date: Available online 28 April 2019Source: Journal of Orthopaedic TranslationAuthor(s): Luanluan Jia, Fengxuan Han, Huan Wang, Caihong Zhu, Qianping Guo, Jiaying Li, Zhongliang Zhao, Qiang Zhang, Xuesong Zhu, Bin LiAbstractAlong with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring met...
Source: Journal of Orthopaedic Translation - April 29, 2019 Category: Orthopaedics Source Type: research
Bevacizumab tested for treatment of knee osteoarthritis via inhibition of synovial vascular hyperplasia in rabbits
ConclusionsIntra-articular injection of 4-mg bevacizumab in rabbit knees did not show adverse effects. The bevacizumab treatment prevented joint inflammation in terms of inhibition of reduced angiogenesis, inhibited synovial proliferation, and reduced VEGF and MMP-1 expression. Compared with SH and TA, bevacizumab protected the cartilage and produced a better therapeutic effect on primary knee OA in rabbits, which imply that bevacizumab, an anticancer drug, may become a potentially effective drug for the treatment of OA. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - April 29, 2019 Category: Orthopaedics Source Type: research
Treatment of femoral neck nonunion with a new fixation construct through the Watson-Jones approach
ConclusionTheDCS and MABP with autogenous iliac bone graft through the Watson-Jones approach is an effective option for the treatment of femoral neck nonunion or delayed healing. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - April 29, 2019 Category: Orthopaedics Source Type: research
Haem oxygenase-1 induction prevents glucocorticoid-induced osteoblast apoptosis through activation of extracellular signal–regulated kinase1/2 signalling pathway
ConclusionOur results demonstrate that HO-1 induction by CoPP can attenuate Dex-induced apoptosis of mouse osteoblastic MC3T3-E1 cells. The antiapoptotic effect of HO-1 induction may be correlated with the activation of ERK1/2 signalling pathway.The translational potential of this article: HO-1 induction by CoPP can prevent GC-induced osteoblast apoptosis. Our findings will highlight the therapeutic potential of HO-1 induction in GC-induced osteoporosis. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - April 29, 2019 Category: Orthopaedics Source Type: research
The efficacy and safety of intravenous tranexamic acid in hip fracture surgery: A systematic review and meta-analysis
ConclusionsThis meta-analysis of the available evidence implies that the intravenous route of TXA shows an ability to reduce transfusion requirements and total blood loss, not increasing the incidence of thromboembolic events in patients undergoing hip surgeries.The translational potential of this articleThe result of this meta-analysis shows that the utilization of intravenous TXA in patients with hip fracture undergoing hip surgeries possesses great potential in reducing blood loss and allogeneic blood transfusion safely. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - April 20, 2019 Category: Orthopaedics Source Type: research
Effect of porous tantalum on promoting the osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the MAPK/ERK signal pathway
ConclusionOverall, our research found that compared with the widely used titanium alloy materials, our pTa can promote the adhesion and proliferation of BMSCs, and the molecular mechanism of pTa may occur via activation of the MAPK/ERK signalling pathway to regulate the high expression of OSX, Col I, OSN and OCN osteogenic genes and promote the osteogenic differentiation of BMSCs in vitro.The translational potential of this article: Our self-developed pTa material produced by three-dimensional printing combined with the chemical vapour deposition method not only retains excellent biological activity and osteoinductive a...
Source: Journal of Orthopaedic Translation - April 15, 2019 Category: Orthopaedics Source Type: research
Translation of bone wax and its substitutes: History, clinical status and future directions
Publication date: Available online 11 April 2019Source: Journal of Orthopaedic TranslationAuthor(s): Huan Zhou, Jun Ge, Yanjie Bai, Chunyong Liang, Lei YangAbstractBone wax, primarily composed of beeswax and softening agent, is a century-old material used to control bleeding of disrupted bone surfaces by acting as a mechanical barrier to seal the wound. The current bone wax products are commonly packed in easy-to-open foil in the form of sterile sticks or plates, with excellent malleability and smooth consistency, enabling cost-effective and easy handling approach for bleeding control. It has also been reported that the i...
Source: Journal of Orthopaedic Translation - April 13, 2019 Category: Orthopaedics Source Type: research
Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models
In this study, we designed graded porous structures using triply periodic minimal surface models to mimic the biomechanical properties of bone and evaluated the mechanical properties and bone formation ability. The scaffolds were designed using a P-surface with different pore sizes. All materials were fabricated using three-dimensional printing technology, and the mechanical properties were tested by an electronic universal testing device. The biomechanical properties were then analysed by the finite element method, while the ontogenesis of the material in vivo was examined by implanting the scaffolds for five weeks in p...
Source: Journal of Orthopaedic Translation - April 7, 2019 Category: Orthopaedics Source Type: research
Necrotizing fasciitis induced by Vibrio vulnificus in patients without marine contact in Hong Kong
We present two cases of Vibrio vulnificus necrotizing fasciitis in the upper limb without any wounds or seawater contact and with good past medical history. Both underwent timely surgical debridement and resulted with good functional outcome. Although rare, as clinicians, we need to have a high index of suspicion for the possibility of V. vulnificus necrotizing fasciitis despite no risk factors and give timely and appropriate treatment and, more importantly, patient survival. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - April 6, 2019 Category: Orthopaedics Source Type: research
Sargassum integerrimum inhibits oestrogen deficiency and hyperlipidaemia-induced bone loss by upregulating nuclear factor (erythroid-derived 2)-like 2 in female rats
ConclusionOur data indicate that rats exposed to SI treatment for 12 weeks did not exhibit noticeable side effects. In conclusion, SI suppressed bone loss induced by ovariectomized and the associated HLP in rats by activating Nrf2, which could be a promising treatment option for osteoporosis induced by oestrogen deficiency and HLP in postmenopausal women. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - March 28, 2019 Category: Orthopaedics Source Type: research
Emerging opportunities for induced pluripotent stem cells in orthopaedics
Publication date: Available online 25 March 2019Source: Journal of Orthopaedic TranslationAuthor(s): Wan-Ju Li, Hongli Jiao, Brian E. WalczakAbstractThe discovery of induced pluripotent stem cells (iPSCs) has revolutionised biomedicine. Although the potential of iPSCs for tissue regeneration, disease modelling and drug screening has been largely recognised, findings of iPSC research to date are mostly focused on neurology, cardiology and haematology. For orthopaedics, growing interest in the unique cell type has prompted more researchers to get involved in iPSC research. In this article, we introduce the brief history of...
Source: Journal of Orthopaedic Translation - March 27, 2019 Category: Orthopaedics Source Type: research
A novel protocol for isolation and culture of multipotent progenitor cells from human urine
Publication date: Available online 16 March 2019Source: Journal of Orthopaedic TranslationAuthor(s): Weiping Lin, Liangliang Xu, Gang LiSummaryCell therapy holds promise for treating a variety of diseases. Seeking available source of adult stem cells remains a great challenge in cell therapy. Urine is considered as an ideal source of adult stem cells which can be easily acquired by noninvasive methods. However, specific cell types in urine have not been well documented. Here, the aim of our study is to identify cell types in urine, and isolate and expand progenitor/stem cells from human urine and further evaluate their mul...
Source: Journal of Orthopaedic Translation - March 17, 2019 Category: Orthopaedics Source Type: research
