Current surgical options and innovation for repairing articular cartilage defects in the femoral head
Publication date: Available online 10 August 2019Source: Journal of Orthopaedic TranslationAuthor(s): Dajiang Du, Peichun Hsu, Zhenzhong Zhu, Changqing ZhangAbstractTotal hip arthroplasty is a common surgical technique, yet it has severe complications, such as loosening and repeated revision. Thus, hip-preserving surgical options should be considered first to treat cartilage defects in the femoral head, especially for younger patients. Current surgical options for chondral repair of the femoral head include microfracture, trapdoor procedure, transplantation of osteochondral allografts and autografts, and autologous chondro...
Source: Journal of Orthopaedic Translation - August 10, 2019 Category: Orthopaedics Source Type: research
How much do we know about the role of osteocytes in different phases of fracture healing? A systematic review
ConclusionTo further illustrate the function of osteocytes, additional longitudinal studies with appropriate clinically relevant model to study osteoporotic fractures are crucial. Future investigations on the morphological changes of osteocyte lacuno-canalicular network during healing, osteocyte-mediated signalling molecules in the transforming growth factor-beta-Smad3 pathway, perilacunar remodelling, type of fixation and putative biomarkers to monitor fracture healing are highly desirable to bridge the current gaps of knowledge.The translational potential of this article: This systematic review provides an up-to-date chr...
Source: Journal of Orthopaedic Translation - August 9, 2019 Category: Orthopaedics Source Type: research
Early degeneration of the meniscus revealed by microbiomechanical alteration in a rabbit anterior cruciate ligament transection model
ConclusionThe microbiomechanical properties in the meniscus changed significantly after ACLT and were site dependent. Their alterations occurred before the histological changes of degeneration were observed.The Translational Potential of this ArticleThe results of our study indicated that degeneration promoted meniscus stiffening. Thus, they provide a better understanding of the disease process affecting the meniscus. Our results might be beneficial to understand how mechanical forces distribute throughout the healthy and pathologic joint. They indicate the possibility of early diagnosis using a minimally invasive arthrosc...
Source: Journal of Orthopaedic Translation - August 9, 2019 Category: Orthopaedics Source Type: research
Basic fibroblast growth factor and agarose gel promote the ability of immune privilege of allogeneic cartilage transplantation in rats
ConclusionsAllogeneic cartilage transplantation induces acute immune rejection, which compromises the validity of the implant. The combination of basic fibroblast growth factor and agarose gel facilitates the goal of immune privilege and promotes the success of the allograft tissues. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 9, 2019 Category: Orthopaedics Source Type: research
Prevalence of patellofemoral joint osteoarthritis after anterior cruciate ligament injury and associated risk factors: A systematic review
ConclusionsLarge variations of PFJ OA after ACL injury are associated with different follow-up period and surgical techniques. ACL reconstructed population with bone-patellar tendon-bone graft, single-bundle reconstruction, and delayed operation time has a high prevalence of PFJ OA. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Percutaneous vertebral augmentation in special Genant IV osteoporotic vertebral compression fractures
ConclusionDespite a great challenge, vertebral augmentation can be considered as a safe and effective option for treating special the Genant IV OVCF, showing significant restoration of vertebral body height, local kyphotic angle, and daily life function. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signaling
ConclusionThese results suggested that AP significantly abolished the DOX-induced stemness phenotype and metastasis capacity in osteosarcoma cells by inhibiting Sox2 via STAT3 signalling. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Three-dimensional finite-element analysis of aggravating medial meniscus tears on knee osteoarthritis
This study does favour to obtain a better understanding on the symptoms and pathological changes of OA. It also may provide some potential directions for the prophylaxis and treatment of OA. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Benefits of opposite screw insertion technique in medial open-wedge high tibial osteotomy: A virtual biomechanical study
ConclusionThe present study revealed that pretensioned opposite lag screw insertion is a simple and effective technique to improve the structural stability in medial open-wedge HTO. Further biomechanical and clinical verification will be required to enhance user confidence in this technique. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Prediction on the plantar fascia strain offload upon Fascia taping and Low-Dye taping during running
ConclusionFrom a mechanical point of view, our study provided quantitative evidence to support the application of taping treatments for overstrained plantar fascia. The untensed fascia band by Fascia taping could be a potential indicator of pain relief for the runners. However, a prospective study targeting the patient population would be needed to address the point.The Translational Potential of this ArticleThe study quantified the loading status of the plantar fascia during running and provided mechanical evidence to support the usage of taping as a mean to reduce fascial strain, thus possibly controlling injury risks fo...
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research
Clinical neurorestorative therapeutic guidelines for spinal cord injury (International Association of Neurorestoratology/Chinese Association of Neurorestoratology version 2019)
Publication date: Available online 9 July 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Shiqing Feng, Milan Dimitrijevic, Yaping Feng, Wise Young, Tiansheng Sun, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari S. Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, The International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration following spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the...
Source: Journal of Orthopaedic Translation - July 10, 2019 Category: Orthopaedics Source Type: research
Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production
ConclusionIn summary, our study has identified BMP-7 as a key osteoinductive factor in injured muscle that facilitates HO formation.The translational potential of this articleOur results provide a candidate mechanistic rationale for the use of antiinflammatory drugs in the prevention of HO. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - July 7, 2019 Category: Orthopaedics Source Type: research
Optimization of electrospray fabrication of stem cell–embedded alginate–gelatin microspheres and their assembly in 3D-printed poly(ε-caprolactone) scaffold for cartilage tissue engineering
ConclusionOptimization of hBMSC-embedded Alg-Gel microspheres produced by electrospray has been performed. The Alg-Gel composition selected allows conservation of hBMSC viability and supports proliferation and matrix deposition. The possibility to seed and assemble microspheres in designed 3D-printed PCL scaffolds for the fabrication of a mechanically stable and biological supportive tissue engineering cartilage construct was demonstrated.Translational potential of this articleWe optimize and demonstrate that electrospray microsphere fabrication is a cytocompatible and facile process to produce the hBMSC-embedded m...
Source: Journal of Orthopaedic Translation - June 26, 2019 Category: Orthopaedics Source Type: research
Lateral slit delivery of bone marrow stromal cells enhances regeneration in the decellularized allograft flexor tendon
ConclusionBMSCs proliferated and remained viable after 2 and 4 weeks of culture with distribution throughout the lateral slits. Lateral slit preparation allows for the effective delivery and maintenance of mesenchymal cells with proliferation and generating a tenogenic behaviour of DCT in both the low and high cell densities in an in vitro model.The translation potential of this articleRevitalizing the implanted decellularized allograft is important for clinical application. In this study, we demonstrated that the DCT, with lateral slits, could harbour the seeded stem cell and stimulate proliferation with collagen synthes...
Source: Journal of Orthopaedic Translation - June 7, 2019 Category: Orthopaedics Source Type: research
Degenerative musculoskeletal diseases: Pathology and treatments
Publication date: April 2019Source: Journal of Orthopaedic Translation, Volume 17Author(s): Bin Li, Di Chen (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - June 5, 2019 Category: Orthopaedics Source Type: research
