Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population
ConclusionsIn an orthopaedic oncology population, the PROMIS Physical Function and Pain Interference scores correlate with the TESS and have the benefit of reduced survey burden and ceiling effect. The PROMIS Depression scores may provide additional information regarding patient outcomes not captured by the TESS.Level of EvidenceLevel III. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - March 8, 2019 Category: Orthopaedics Source Type: research
Characterisation of multipotent stem cells from human peripheral blood using an improved protocol
This study was conducted to evaluate the multipotency of PB-derived MSCs (PB-MSCs) and effects of human PB-MSC transplantation on ectopic bone regeneration in nude mice. Ten millilitres of venous blood was collected from five healthy donors with heparin, and the red blood cells were removed using red blood cell lysis buffer. The cell suspension was cultured under normoxia culture and hypoxia culture conditions. The nonadherent cells were removed by changing 50% of the culture media every other day. The adherent cells were then passaged and subjected to in vitro multidifferentiation assays and in vivo ectopic bone forma...
Source: Journal of Orthopaedic Translation - March 7, 2019 Category: Orthopaedics Source Type: research
Incidence of a stem sitting proud of a proximally coated cementless tapered wedge stem
ConclusionThe proximally coated tapered wedge stems present potential problems related to stem SP. The new rasp of the M/L Taper stem showed significant improvement in initial seating height. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - March 6, 2019 Category: Orthopaedics Source Type: research
Andrographolide stimulates osteoblastogenesis and bone formation by inhibiting nuclear factor kappa-Β signaling both in vivo and in vitro
This study provides strong evidence for the identification that AP has both antiresorptive and osteoanabolic activities and thus has great potential to be developed as a novel antiosteoporosis agent. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - March 4, 2019 Category: Orthopaedics Source Type: research
Label-free cell sorting strategies via biophysical and biochemical gradients
Publication date: Available online 26 February 2019Source: Journal of Orthopaedic TranslationAuthor(s): Zhengkun Chen, Xiaohe Luo, Xin Zhao, Mo Yang, Chunyi WenAbstractIsolating active mesenchymal stem cells from a heterogeneous population is an essential step that determines the efficacy of stem cell therapy such as for osteoarthritis. Nowadays, the gold standard of cell sorting, fluorescence-activated cell sorting, relies on labelling surface markers via antibody–antigen reaction. However, sorting stem cells with high stemness usually requires the labelling of multiple biomarkers. Moreover, the labelling process is cos...
Source: Journal of Orthopaedic Translation - February 26, 2019 Category: Orthopaedics Source Type: research
Analysis of acetabular version: Retroversion prevalence, age, side and gender correlations
ConclusionWomen have a higher average acetabular version than men. Retroversion in a young adult population has a low prevalence when measured with conventional CT. About a tenth of the population has a significantly different contralateral acetabular version.The translational potential of this articleGlobal acetabular retroversion has a much lower prevalence than previously reported. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - February 15, 2019 Category: Orthopaedics Source Type: research
Treatment of trauma-induced femoral head necrosis with biodegradable pure Mg screw-fixed pedicle iliac bone flap
ConclusionPure Mg screw fixation pedicled bone flap transplantation is an effective surgical treatment for femoral head necrosis in young patients. Pure Mg screw is a biodegradable internal fixation device with good biocompatibility, which has a good clinical application prospects. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - February 15, 2019 Category: Orthopaedics Source Type: research
Changes of median nerve conduction, cross-sectional area and mobility by radioulnar wrist compression intervention in patients with carpal tunnel syndrome patients
ConclusionThis study revealed that RWC intervention with 10-N force applied to the wrist in the radioulnar direction could restore impaired neurophysiological and biomechanical functions of the median nerve. The beneficial effects of RWC intervention for the median nerve were in evidence after a relatively short period of two weeks. These functional improvements could be explained by intermittent decompression of the median nerve via RWC-induced augmentation of the carpal arch.The translational potential of this articleBiomechanically manipulating the carpal tunnel by RWC decompresses the median nerve and has the potential...
Source: Journal of Orthopaedic Translation - February 14, 2019 Category: Orthopaedics Source Type: research
Enhancement of rotator cuff tendon–bone healing using bone marrow–stimulating technique along with hyaluronic acid
ConclusionHA may play a crucial role in the acceleration of tendon-to-bone healing which might be through inhibiting inflammation. Rotator cuff repair using MF along with HA led to better tendon–bone healing and a subsequent increase of biomechanical strength at the repair site.The translational potential of this articleHA injection is very common for patients with rotator cuff disease because of its antiinflammatory action and adhesion prevention preoperatively. The HA injection during surgery provides an antiinflammatory effect during tendon–bone healing process and leads to better tendon–bone healing postoperativ...
Source: Journal of Orthopaedic Translation - January 29, 2019 Category: Orthopaedics Source Type: research
Optimization strategies for ACI: A step-chronicle review
Publication date: Available online 29 January 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yuchen Xiang, Varitsara Bumpetch, Wenyan Zhou, Hongwei OuyangAbstractBearing compression from adjacent joints, the articular cartilage is cumulatively pressured in daily life, thus making it prone to injuries; however, once damaged, the self-healing capacity of articular cartilage is limited owing to its low metabolic property. Autologous chondrocyte implantation, a three-step repairing technique for articular lesions, has received satisfactory short-term clinical outcomes, whereas its long-term effect remains controversi...
Source: Journal of Orthopaedic Translation - January 29, 2019 Category: Orthopaedics Source Type: research
Normal intervertebral segment rotation of the subaxial cervical spine: An in vivo study of dynamic neck motions
Publication date: Available online 21 January 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yan Yu, Jing-Sheng Li, Tao Guo, Zhao Lang, James D. Kang, Liming Cheng, Guoan Li, Thomas D. Cha (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 22, 2019 Category: Orthopaedics Source Type: research
Effect of degenerative and radial tears of the meniscus and resultant meniscectomy on the knee joint: a finite element analysis
ConclusionOur finite element model provides a realistic three-dimensional knee model to investigate the effects of degenerative and radial meniscal tears and resultant meniscectomy on the stress distribution of the knee. The stress was increased in meniscal tears and increased significantly when meniscectomy was performed. Increased meniscus extrusion may explain the mechanism for higher stress on the components of the knee.The translational potential of this articleMeniscal tears are the most common damage associated to the menisci, and meniscectomy is often performed to relieve the pain and instability of the knee. The r...
Source: Journal of Orthopaedic Translation - January 21, 2019 Category: Orthopaedics Source Type: research
Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis
Publication date: Available online 7 January 2019Source: Journal of Orthopaedic TranslationAuthor(s): Bo Chen, Qiaoyan Tan, Hangang Chen, Fengtao Luo, Meng Xu, Jianhua Zhao, Peng Liu, Xianding Sun, Nan Su, Dali Zhang, Weili Fan, Mingyong Liu, Haiyang Huang, Zuqiang Wang, Junlan Huang, Ruobin Zhang, Can Li, Fangfang Li, Zhenhong Ni, Xiaolan Du (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 8, 2019 Category: Orthopaedics Source Type: research
Plain radiography findings to predict dislocation after total hip arthroplasty
ConclusionsPatients with soft tissue imbalance, across joint deformity around hips and bilateral pathological hips seem more predisposed to suffer from dislocation after THA. Appropriate surgical intervention strategies along with meticulously postoperative management may help preventing dislocation after THA.The translational potential of this articleA better understanding of the probable causes of dislocation after THA proposed a new clinical application of plain radiography. This radiography-related clinical research may reveal the novel mechanism of dislocation after THA and new preventive measures. (Source: Journal of...
Source: Journal of Orthopaedic Translation - January 6, 2019 Category: Orthopaedics Source Type: research
Bioactive scaffolds for osteochondral regeneration
Publication date: Available online 26 December 2018Source: Journal of Orthopaedic TranslationAuthor(s): Cuijun Deng, Jiang Chang, Chengtie WuAbstractTreatment for osteochondral defects remains a great challenge. Although several clinical strategies have been developed for management of osteochondral defects, the reconstruction of both cartilage and subchondral bone has proved to be difficult due to their different physiological structures and functions. Considering the restriction of cartilage to self-healing and the different biological properties in osteochondral tissue, new therapy strategies are essential to be develop...
Source: Journal of Orthopaedic Translation - December 27, 2018 Category: Orthopaedics Source Type: research
