Optimization strategies for ACI: A step-chronicle review

Publication date: Available online 29 January 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yuchen Xiang, Varitsara Bumpetch, Wenyan Zhou, Hongwei OuyangAbstractBearing compression from adjacent joints, the articular cartilage is cumulatively pressured in daily life, thus making it prone to injuries; however, once damaged, the self-healing capacity of articular cartilage is limited owing to its low metabolic property. Autologous chondrocyte implantation, a three-step repairing technique for articular lesions, has received satisfactory short-term clinical outcomes, whereas its long-term effect remains controversial. Currently, improved stem-cell therapies and novel biomaterials have shed new lights on autologous chondrocyte implantation. We would, therefore, synthesize these optimization strategies in order of their presences in the three-step protocol, seeking to find and amplify synergic effects between these strategies.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research