The influence of sample size and gender composition on the metaanalysis conclusion of platelet-rich plasma treatment for osteoarthritis
ConclusionsAccording to the currently available data, PRP injections are beneficial for pain relief and function improvement in patients with OA. This metaanalysis, however, demonstrated that the efficacy of PRP is related to sample size and gender composition. Thus, more randomised controlled trials of high quality and larger patient size, also including gender aspects, are required to understand this phenomenon. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 16, 2019 Category: Orthopaedics Source Type: research
Three-dimensional distribution of cystic lesions in osteonecrosis of the femoral head
ConclusionsCystic lesions most often occur at the junction of the necrotic ​and normal areas and are most commonly located in the anterolateral femoral head, which is similar to the distribution of the stress concentration region. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 14, 2019 Category: Orthopaedics Source Type: research
Comparing clinical outcomes of using 3 versus 5 titanium miniplates in laminoplasty for multilevel cervical myelopathy: A prospective cohort study
ConclusionCervical EOLP using 3 titanium miniplates is associated with shorter operation times, less blood loss, and lower operation costs compared with using 5 titanium miniplates. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 14, 2019 Category: Orthopaedics Source Type: research
Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)
Publication date: Available online 11 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Wise Young, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari Shanker Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, Shiqing Feng, International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, â...
Source: Journal of Orthopaedic Translation - November 12, 2019 Category: Orthopaedics Source Type: research
Underreporting characteristics of osteoporotic vertebral fracture in back pain clinic patients of a tertiary hospital in China
ConclusionAmong the patients with VCD/VCF, the false negative rate among was 23.9% (17/71), but the missed cases were all minimal or mild grades. One or more VCFs were missed in 32.4% (23/71) of the cases with multiple VCFs. Appropriate severity grading was not reported for most cases. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 10, 2019 Category: Orthopaedics Source Type: research
Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats
ConclusionsSpinal instability induced by CMS increases bone mass and biomechanical loading of the ventral side of vertebrae in the early stage, which might initiate VEP damage and cause intervertebral disc degeneration.The translational potential of this articleOur study indicates that vertebral trabecular changes may involve in intervertebral disc degeneration induced by spinal instability. This may help to elucidate the mechanisms by which disc degeneration occur. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 7, 2019 Category: Orthopaedics Source Type: research
Development of generic Asian pelvic bone models using CT-based 3D statistical modelling
Publication date: Available online 4 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Marc-Daniel Ahrend, Hansrudi Noser, Rukmanikanthan Shanmugam, Felix Burr, Lukas Kamer, Tunku Kamarul Zaman, Heinz Hügli, Andreas Nagy, Robert Geoff Richards, Boyko Gueorguiev-RüeggAbstractBackground/ObjectiveArtificial bone models (ABMs) are used in orthopaedics for research of biomechanics, development of implants and educational purposes. Most of the commercially available ABMs approximate the morphology of Europeans, but they may not depict the Asian anatomy. Therefore, our aim was to develop the first Asian ABM of t...
Source: Journal of Orthopaedic Translation - November 5, 2019 Category: Orthopaedics Source Type: research
Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model
ConclusionsQuadriceps muscle atrophy triggered the subchondral bone abnormal change and cartilage degeneration, which would be a risk factor for development of osteoarthritis. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 2, 2019 Category: Orthopaedics Source Type: research
Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon
ConclusionTaken together, this study showed that TSPCs are capable of differentiating towards fibrocartilage-like cells, and the fibrochondrogenic characteristics were conserved even in vivo, and thus might have the potential application for fibrocartilage regeneration in BTJ repair.The translational potential of this articleTSPCs are able to differentiate into fibrocartilage-like cells and thus might well be one potential cell source for fibrocartilage regeneration in a damaged BTJ repair. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 2, 2019 Category: Orthopaedics Source Type: research
Comparison of O-arm navigation and microscope-assisted minimally invasive transforaminal lumbar interbody fusion and conventional transforaminal lumbar interbody fusion for the treatment of lumbar isthmic spondylolisthesis
ConclusionNavigation and microscope-assisted MIS-TLIF is safe and reliable for treatment of lumbar isthmic spondylolisthesis (Meyerding degree I or II) with potential advantages including less injury, less blood loss, higher screw accuracy and faster recovery after operation. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 1, 2019 Category: Orthopaedics Source Type: research
Stearic acid methyl ester ​promotes migration of mesenchymal stem cells and accelerates cartilage defect repair
Publication date: Available online 23 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yamei Liu, Liangliang Xu, Liuchao Hu, Dongfeng Chen, Lijuan Yu, Xican Li, Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo, Bin Wang, Gang LiAbstractMesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homin...
Source: Journal of Orthopaedic Translation - October 24, 2019 Category: Orthopaedics Source Type: research
A novel percutaneous crossed screws fixation in treatment of Day type II crescent fracture–dislocation: A finite element analysis
ConclusionsWith sufficient biomechanical stability and minimally invasive advantage, percutaneous crossed screw fixation is a recommended treatment for Day Type-II Crescent Fracture–dislocation. It is recommended to fix crescent fracture fragment and sacroiliac joint simultaneously during the operation. If it is difficult to fix the both position, the sacroiliac joint is preferentially fixed.The translational potential of this articleThere is a controversy on the operative approach and fixation technique of Day type-II crescent fracture–dislocation. This article proves that percutaneous crossed screw fixation is a reco...
Source: Journal of Orthopaedic Translation - October 23, 2019 Category: Orthopaedics Source Type: research
Systematic effects of femoral component rotation and tibial slope on the medial and lateral tibiofemoral flexion gaps in total knee endoprostheses
ConclusionFor established surgical methods, we recommend a neutral femur rotation for a 0° tibial slope and a 3° external femur rotation for a tibial slope of 9–10°. The translational potential of this research shows that while the rotation of the femoral component in extension has no effect on the gap size, owing to the axis of rotation being perpendicular to the gap, for a 90° flexion, we not only observe differences in the gap size between the medial and lateral ​but also unequal differences on either side depending on the inward or outward rotation. The main reason for this is the position of the axis of rotat...
Source: Journal of Orthopaedic Translation - October 23, 2019 Category: Orthopaedics Source Type: research
Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants
In this study, a facile method was applied to fabricate a zoledronate-loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca–P chelation with BPs. The results showed that the fluoride-pretreated coating could provide better corrosion resistance. Zoledronic acid was successfully loaded on the surface of Mg alloy, detected by X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analysis, and the release profile was quantified by UV detection. It is considered that this construction of zoledronate-coated Mg-based orthopaedic implants could be easily and ef...
Source: Journal of Orthopaedic Translation - October 20, 2019 Category: Orthopaedics Source Type: research
State-of-the-art research in robotic hip exoskeletons: A general review
Publication date: Available online 14 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Bing Chen, Bin Zi, Ling Qin, Qiaosheng PanAbstractAgeing population is now a global challenge, where physical deterioration is the common feature in elderly people. In addition, the diseases, such as spinal cord injury, stroke, and injury, could cause a partial or total loss of the ability of human locomotion. Thus, assistance is necessary for them to perform safe activities of daily living. Robotic hip exoskeletons are able to support ambulatory functions in elderly people and provide rehabilitation for the patients with...
Source: Journal of Orthopaedic Translation - October 15, 2019 Category: Orthopaedics Source Type: research
