Design of a new magnesium-based anterior cruciate ligament interference screw using finite element analysis
ConclusionIt was concluded that improving the design of a Mg-based screw may increase surgical success rates, by decreasing device failure at insertion.The translational potential of this articleThe results of this work have the potential to improve designs of degradable IFSs, allowing for greater torque to be applied and thus greater screw fixation between host bone and the graft. Such a fixation will allow greater integration, better patient healing, and ultimately improved patient outcomes. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 15, 2019 Category: Orthopaedics Source Type: research
Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview
Publication date: Available online 8 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Meng Zhang, Jukka P. Matinlinna, James K.H. Tsoi, Wenlong Liu, Xu Cui, William W. Lu, Haobo PanAbstractReconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone...
Source: Journal of Orthopaedic Translation - October 9, 2019 Category: Orthopaedics Source Type: research
Different subchondral trabecular bone microstructures and biomechanical properties between developmental dysplasia of the hip and primary osteoarthritis
ConclusionOur findings detected deteriorating subchondral trabecular bone microstructures in patients with DDH. The mass and type of subchondral trabecular bone play a key role in mechanical properties in DDH, which might be related to cartilage damage.The translational potential of this articleOur findings suggested that changes of subchondral trabecular bone play a critical role in DDH progression and that the improvement on subchondral trabecular bone may be a sensitive and promising way in treatment of DDH. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 28, 2019 Category: Orthopaedics Source Type: research
Reduced expression of carbonic anhydrase III in skeletal muscles could be linked to muscle fatigue: A rat muscle fatigue model
ConclusionsOur study showed that soleus muscle fatigue induced by electrical stimulation could result in downregulation of CAIII and ATP levels and accumulation of lactic acid and MDA. Further study showed that CAIII knockdown led to more reduction of the maximal muscle force, whereas CAIII overexpression showed less reduction of the maximal muscle force, which suggested that CAIII levels in muscles might be related to the occurrence of muscle fatigue. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 24, 2019 Category: Orthopaedics Source Type: research
Long-term outcome after revision of hip arthroplasty with the BioBall® adapter system in multimorbid patients
ConclusionsIn multimorbid patients, using the BioBall® adapter system for total hip arthroplasty, revision due to dislocation results in good long-term outcome without impairment of quality of life. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 21, 2019 Category: Orthopaedics Source Type: research
A preliminary study of a novel robotic system for pedicle screw fixation: A randomized controlled trial
ConclusionThe outcome of screw accuracy of this robotic system was comparable with that of experienced surgeons, and no screw-related complication was found in the RA group during hospitalization. In addition, radiation time per screw in the robotic group was significantly lower than that in the conventional group, which shows the potential to reduce radiation exposure of pedicle screw fixation assisted by this robotic system. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 18, 2019 Category: Orthopaedics Source Type: research
Does mobile-bearing have better flexion and axial rotation than fixed-bearing in total knee arthroplasty? A randomised controlled study based on gait
ConclusionsTKA can make the parameters of knee gait characteristics closer to the normal population. Medial knee osteoarthritis patients who received a MB prosthesis in TKA had better joint flexion function and axial rotation than the FB one. However, there is insufficient evidence to suggest that the MB prosthesis is a better option for patients with medial knee osteoarthritis.The translational potential of this articleTo date, no consensus for prosthesis selection in TKA has been established. This study found significant differences in joint flexion/extension angle and internal/external rotation during gait post-TKA surg...
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research
Evaluation of hollow mesh augmentation on the biomechanical properties of the flexor tendon repaired with modified Kessler technique
ConclusionOur data have demonstrated that MK repair augmented with the centre hollow mesh suture increased failure strength without inducing increased friction.The translational potential of this articleOur study elucidates that a Tri-C augmentation designed in this study can achieve mechanical enhancements without increasing the repaired tendon friction. Hence, this novel technique has potential biological validity and clinical application. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research
The efficacy and safety of denosumab in postmenopausal women with osteoporosis previously treated with bisphosphonates: A review
ConclusionThe outcomes and treatment compliance were improved in postmenopausal osteoporotic women who shifted to denosumab from bisphosphonates.The translational potential of this articleThe replacement of bisphosphonates with denosumab may lead to better therapeutic efficacy and fewer adherence barriers than those with continued usage of bisphosphonates, which in the future may guide the choice of drug therapy in clinics. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research
Association between the ABO blood group and primary knee osteoarthritis: A case–control study
ConclusionsThis study suggested that the blood group AB was associated with primary knee osteoarthritis, as well as its radiological severity. Further study indicated that LeY antigen, which was related to the blood group, was associated with primary knee osteoarthritis. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 6, 2019 Category: Orthopaedics Source Type: research
A novel percutaneous crossed screws fixation in treatment of Day type II crescent fFracture–dislocation: A finite element analysis
ConclusionsWith sufficient biomechanical stability and minimally invasive advantage, percutaneous crossed screw fixation is a recommended treatment for Day Type-II Crescent Fracture–dislocation. It is recommended to fix crescent fracture fragment and sacroiliac joint simultaneously during the operation. If it is difficult to fix the both position, the sacroiliac joint is preferentially fixed. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 5, 2019 Category: Orthopaedics Source Type: research
A novel calcium phosphate–based nanocomposite for the augmentation of cement-injectable cannulated pedicle screws fixation: A cadaver and biomechanical study
ConclusionA new nanocomposite cement CPN, designed for replacing the nondegradable PMMA cement and overcoming the mechanical inferiority of calcium phosphate cement, was evaluated for its biomechanical and biodegradation behaviours in CICPS application. Although CPN is a mechanically weaker material than PMMA, CPN demonstrates similar biomechanical properties to PMMA in the application of augmentation for CICPS fixation in cadaveric vertebrae. This improvement in biomechanical property is attributed to a better dispersion and interdigitation mode of CPN. In addition, the animal study results suggest the in vivo absorption ...
Source: Journal of Orthopaedic Translation - September 5, 2019 Category: Orthopaedics Source Type: research
Development of bone seeker–functionalised microspheres as a targeted local antibiotic delivery system for bone infections
ConclusionWe report the development and characterisation of a DDS which can release antibiotics in a sustained manner. Surface-grafted alendronate groups enhanced bone affinity of the microsphere construct, resulting in a bone targeting DDS.The Translational Potential of this ArticleThe DDS presented can be loaded with hydrophobic antibiotics, representing a potential, versatile and biodegradable candidate to locally treat bone infection. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 31, 2019 Category: Orthopaedics Source Type: research
Letter to the editor concerning “Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis” by Chen et al., Journal of Orthopaedic Translation, 2019, https://doi.org/10.1016/j.jot.2018.12.001
Publication date: Available online 27 August 2019Source: Journal of Orthopaedic TranslationAuthor(s): Rob C. Brink, René M. Castelein (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 29, 2019 Category: Orthopaedics Source Type: research
Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
ConclusionGEN inhibits IL-6–induced VEGF expression and angiogenesis partially through the JAK2/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA.The translational potential of this articleOur study provides scientific guidance for the clinical translational research of GEN in the RA treatment. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 23, 2019 Category: Orthopaedics Source Type: research
