Polydopamine-assisted surface modification for orthopaedic implants

Publication date: Available online 28 April 2019Source: Journal of Orthopaedic TranslationAuthor(s): Luanluan Jia, Fengxuan Han, Huan Wang, Caihong Zhu, Qianping Guo, Jiaying Li, Zhongliang Zhao, Qiang Zhang, Xuesong Zhu, Bin LiAbstractAlong with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring metal ions, has been widely used for surface modification of materials since its discovery in the last decade. PDA and its derivatives can be used for the surface modification of orthopaedic implants to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation, and may thereby enhance the function of existing implants. In addition, the osseointegration and antimicrobial properties of orthopaedic implants may also be improved by PDA-based coatings. The aim of this review is to provide a brief overview of current advances of surface modification technologies for orthopaedic implants using PDA and its derivatives as a medium. Given the versatility of PDA-based adhesion, such PDA-assisted surface modification technologies will certainly benefit the development of new orthopaedic implants.

Source: Journal of Orthopaedic Translation - April 29, 2019 Category: Orthopaedics Source Type: research