Spectroscopic analyses reveal radiotherapy-induced variations in elemental composition and crystallite properties of human permanent teeth envamel
ConclusionsRadiotherapy can induce significant variations in the inorganic and organic functional groups constituting the tooth enamel surface; and these variations are dose dependent. The mechanism responsible for delamination and radiation caries needs to be explored by studying the protein lysis pattern, which might be a leading factor causing the enamel degradation and radiation caries. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 26, 2019 Category: Biomedical Science Source Type: research
The rise in glucose concentration in saliva samples mixed with test foods monitored using a glucometer: An observational pilot study
ConclusionsThis pilot study presents glucose release rate characteristics from specific food particles mixed with saliva in vitro suggesting that the same process takes place in the oral cavity. However, the characteristics of this process when occurring in the mouth would expectedly be modified by different factors such as rinsing effect of salivary flow, oral temperature, etc. Prolonged release of low molecular carbohydrates such as maltose and glucose from food particles can be considered cariogenic and therefore unfavorable for individuals with other risk factors contributing to the development of dental caries. (Sourc...
Source: Journal of Oral Biosciences - October 25, 2019 Category: Biomedical Science Source Type: research
Editorial Board
Publication date: September 2019Source: Journal of Oral Biosciences, Volume 61, Issue 3Author(s): (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 11, 2019 Category: Biomedical Science Source Type: research
Dynamic Photoacoustic Imaging Of Neurovascular Coupling In Salivary Glands
Publication date: Available online 3 September 2019Source: Journal of Oral BiosciencesAuthor(s): Laurie J. Rich, Eftekhar Rajab Bolookat, Mukund SeshadriAbstractThe purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary glands. Dynamic PAI with co-registered ultrasound (US) was performed in mice to monitor salivary gland hemodynamics in response to exogenous muscarinic receptor stimulation (pilocarpine) and blockade (atropine). Pilocarpine increased salivary gland oxygen saturation (%sO2) within minutes after administration, ...
Source: Journal of Oral Biosciences - September 4, 2019 Category: Biomedical Science Source Type: research
Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice
ConclusionThe present study demonstrated the expression patterns of IGF-I, IGF-IR, IGFBP3, and IGFBP5 during odontoblast differentiation in mouse incisors. These results suggested that IGFBP3 regulates the transition from the proliferative to differentiation stage by inhibiting the action of IGF-I on the proliferation of dental papilla cells, and that IGFBP5 plays an important role in the maintenance of the differentiated odontoblasts during tooth development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 17, 2019 Category: Biomedical Science Source Type: research
Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice
ConclusionThese results suggest that RE administration is an effective treatment for symptoms of dryness and may be used in clinical settings against sicca syndrome. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Degradation of extracellular matrices propagates calcification during development and healing in bones and teeth
ConclusionThe ECM proteins may inhibit mineral deposition and calcification, similar to the role of amelogenin during enamel development. The candidates for the amelogenin equivalents in bone and dentin have not been identified. Further studies are required to elucidate the regulatory mechanisms of bone and dentin calcification in light of specific ECM proteins that prevent calcification and enzymes that degrade these ECM proteins. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Regulation of IGF-1 by IGFBP3 and IGFBP5 during odontoblast differentiation in mice
ConclusionThe present study demonstrated the expression patterns of IGF-1, IGF-1R, IGFBP3, and IGFBP5 during odontoblast differentiation in mouse incisors. These results suggested that IGFBP3 regulates the transition from the proliferative to differentiation stage by inhibiting the action of IGF-1 on the proliferation of dental papilla cells, and that IGFBP5 plays an important role in the maintenance of the differentiated odontoblasts during tooth development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Correlation of plasma osteopontin and osteocalcin with lower renal function in dental patients with carotid artery calcification and tooth loss
ConclusionDental patients with CAC and increased tooth loss have a greater tendency for decreased renal function, which may be associated with OPN and OCN; thus, these patients should be referred for investigation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Regulation of osteoclast function via Rho-Pkn3-c-Src pathways
ConclusionWnt5a-Ror2 signaling promotes the bone-resorbing activity of osteoclasts by activating the Daam2-Rho-Pkn3-c-Src pathways. Pkn3 inhibitors, therefore, have potential as therapeutic agents for osteoporosis and bone destruction in inflammatory diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Molecular and cellular basis of hypophosphatasia
ConclusionMolecular characterization of TNSALP mutants helps establish the etiology and onset of HPP. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 8, 2019 Category: Biomedical Science Source Type: research
Comparative assessment of the crystalline structures of powder and bulk human dental enamel by X-ray diffraction analysis
ConclusionsThe results of this study revealed that the sample preparation method for human tooth enamel can affect the crystalline data obtained from XRD analysis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 12, 2019 Category: Biomedical Science Source Type: research
Porcine keratin 75 in developing enamel
ConclusionWe propose that K75 is present in the developing enamel and undergoes different processing/degradation compared to other enamel proteins. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 27, 2019 Category: Biomedical Science Source Type: research
Comparative Assessment of Crystalline Structure of Powder and Bulk Human Dental Enamel Using X-Ray Diffraction Analysis
ConclusionsBased on the results of the current study, the sample preparation method of human tooth enamel can affect the crystalline data obtained from X-ray diffraction analysis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 25, 2019 Category: Biomedical Science Source Type: research
Identification and characterization of novel human papillomaviruses in oral rinse samples from oral cavity and oropharyngeal cancer patients
ConclusionsOur results demonstrated that there are novel HPVs present in oral rinse samples that may be associated with OCC and OPC. These novel HPVs can be identified and characterized using NGS techniques. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 25, 2019 Category: Biomedical Science Source Type: research
