The W9 peptide directly stimulates osteoblast differentiation via RANKL signaling
Conclusions The W9 peptide inhibited RANKL-mediated osteoclast formation in osteoblasts. It also directly stimulated osteoblast differentiation, both via RANKL signaling-mediated autocrine factors, and alternative mechanisms. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 25, 2017 Category: Biomedical Science Source Type: research
Scardovia wiggsiae and its potential role as a caries pathogen
Conclusion S. wiggsiae was associated with advanced and initial caries, is acid tolerant and produces acid to low pH at initial neutral and low pH conditions. In combination with S. mutans, S. wiggsiae was detected in caries in an animal model. Together, these data suggest that S. wiggsiae has many of the characteristics consistent with its being a caries-associated species. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 24, 2017 Category: Biomedical Science Source Type: research
Bone Quality Characteristics Obtained by Fourier Transform Infrared and Raman Spectroscopic Imaging
Conclusion The PO4 3- bands in the FTIR spectra were affected by changes in calcium phosphate composition rather than by changes in crystal size. Thus, FTIR is more suitable for the evaluation of mineral maturity than crystallinity; Raman spectroscopy is more sensitive to crystallinity than FTIR. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 14, 2017 Category: Biomedical Science Source Type: research
Phospholipase C-related catalytically inactive protein-knockout mice exhibit uncoupling protein 1 upregulation in adipose tissues following chronic cold exposure
Conclusion Prip-KO mice exhibit greater ability to consume lipids as an energy source, indicating that PRIP modulates of systemic energy expenditure. Our findings provide increased understanding of PRIP-mediated non-shivering thermogenic mechanisms and offers important insights for the treatment and control of obesity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 13, 2017 Category: Biomedical Science Source Type: research
Molecular mechanisms for activation of mutant activin receptor-like kinase 2 in fibrodysplasia ossificans progressiva
Conclusion BMP type II receptor-dependent phosphorylation of ALK2 mutants in response to ligand binding is important for the activation of BMP signaling in FOP. Therefore, the use of anti-activin A compounds would be a novel treatment approach for FOP. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 13, 2017 Category: Biomedical Science Source Type: research
Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation
Conclusions These results indicate that sustained Sp7 expression in differentiated odontoblasts inhibits odontoblast maturation and reduces the expression of dentin matrix proteins; however, it fails to induce the transdifferentiation of odontoblasts into osteoblasts, which occurs in Runx2 transgenic mice. Therefore, Sp7 expression needs to be down-regulated to an appropriate level for odontoblast maturation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 5, 2017 Category: Biomedical Science Source Type: research
Regulation of hemodynamics in major salivary glands by parasympathetic vasodilation
Conclusion Glandular hemodynamics in the submandibular, parotid, and sublingual glands are regulated by different parasympathetic vasodilator mechanisms, which may functionally contribute to the differences in secretion among the major salivary glands. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 28, 2017 Category: Biomedical Science Source Type: research
Differentiation capacity and maintenance of dental pulp stem/progenitor cells in the process of pulpal healing following tooth injuries
Conclusion Host and recipient interactions that occur with allografts disturb the maintenance of putative stem/progenitor cells, resulting in the disappearance of these cell types. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 22, 2017 Category: Biomedical Science Source Type: research
New functions of lysosomes in bone cells
Conclusion RAB27A participates in bone resorption by LROs in osteoclasts. In addition, lysosomal biogenesis modulated by TFEB is necessary for osteoblastic differentiation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 1, 2017 Category: Biomedical Science Source Type: research
Determinants for selective transport of exogenously expressed cargo proteins into regulated and constitutive secretory pathways
Conclusion In order to study the sorting mechanism for secretory proteins, some evaluation of the cells’ ability to synthesize, transport, and store the proteins is required. The HaloTag method has proved promising for the quantification of transportation in the two pathways. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 24, 2017 Category: Biomedical Science Source Type: research
Japanese workers with long leisure time have deteriorated periodontal condition: A cross-sectional study
Conclusions Subjects with long leisure time showed aggregated periodontal condition consistent with increased serum antibody against periodontal bacteria compared to subjects with short free time. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 23, 2017 Category: Biomedical Science Source Type: research
Premotoneuronal inputs to early developing trigeminal motoneurons
Conclusions These results suggested that, similar to P1–5 motoneurons, both P9–12 motoneurons received convergent inputs from the SupV, IntV, and PrV; however, the input–output gains of some of the premotor neurons decreased. These synaptic input changes may contribute to the proper development of chewing. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 23, 2017 Category: Biomedical Science Source Type: research
Oral Biosciences: The annual review 2016
Conclusion These published reviews in the Journal of Oral Biosciences have inspired the readers of the Journal to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 14, 2016 Category: Biomedical Science Source Type: research
Involvement of microglia and astroglia in modulation of the orofacial motor functions in rats with neuropathic pain
Conclusion The results observed in our studies suggest the involvement of microglia and astroglia in the alteration of orofacial motor activity during neuropathic pain. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 4, 2016 Category: Biomedical Science Source Type: research
Bioactive peptides hidden in human salivary proteins
Conclusion Human salivary proteins have the ability to generate bioactive peptides upon proteolytic cleavage. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 4, 2016 Category: Biomedical Science Source Type: research
