Integration of olfactory and gustatory chemosignals in the insular cortex
Conclusion Several studies, including fMRI analyses in human and animal studies, suggest that the IC directly integrates olfactory and gustatory chemical signals. In particular, our study raises the possibility that the AI plays an important role in integrating olfactory and gustatory signals. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 7, 2016 Category: Biomedical Science Source Type: research
Fine-tuning between BMP and NF-κB pathways regulates osteoblastic bone formation
Conclusion p65 inhibits BMP2-induced osteoblastic bone formation by interfering with DNA binding of the Smad complex via an interaction with Smad4. Thus, targeting the association between p65 and Smad4 may help promote bone regeneration in the treatment of bone diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 31, 2016 Category: Biomedical Science Source Type: research
Cortico-muscular communication for motor control of the tongue in humans: a review
Conclusion This review provides a detailed description of the functional connection between the bilateral cortex and each side of the tongue during sustained tongue movements in humans, using CMC analyses. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 26, 2016 Category: Biomedical Science Source Type: research
Biphasic activation of nuclear factor-kappa B in chondrocyte death induced by interleukin-1beta: The expression of inducible nitric oxide synthase and phagocyte-type NADPH oxidase through immediate and monocarboxylate transporter-1-mediated late-phase activation of nuclear factor-kappa B
Conclusion We found that MCT-1 contributed to the expression of NOX-2 via late-phase activation of nuclear factor κB in a ROS-dependent manner in cells exposed to IL-1β. Hence, MCT-1 could be a potential target for the treatment of degenerative joint diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research
Morphological comparison of the enamel–dentine junction and outer enamel surface of molars using a micro-computed tomography technique
Conclusion A detailed comparison of EDJ and OES using µCT will contribute to our understanding of the phylogenetic relationships among fossil records and evolutionary changes in dental characteristics from the developmental perspective. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research
Mechanistic insight into the aberrant silencing of the keratin 13 gene in oral squamous cell carcinoma cells
Conclusion Identification of epigenetic alterations underlying OSCC will be useful for the development of epigenetic biomarkers for diagnosis and prognosis and the discovery of novel therapeutic targets for OSCC. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 30, 2016 Category: Biomedical Science Source Type: research
The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes
Publication date: Available online 18 November 2015 Source:Journal of Oral Biosciences Author(s): Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metas...
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
Effect of Brazilian green propolis on oral pathogens and human periodontal fibroblasts
Conclusions These results suggest that BGP has antibacterial properties but is not significantly cytotoxic to periodontal fibroblasts. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
Oral biosciences: The annual review 2015
Conclusion These reviews published in the Journal of Oral Biosciences have inspired the readers of the journal to broaden their knowledge regarding various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
Profiling subgingival microbiota of plaque biofilms in the elderly
Conclusions This study suggests that an increase in P. gingivalis and T. forsythia may be associated with periodontitis in the elderly, and we have identified characteristic pathogenic fimA genotypes that target this vulnerable group. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
Streptococcus mutans biofilm formation is dependent on extracellular DNA in primary low pH conditions
Conclusions Insoluble glucan-independent biofilm formation by S. mutans was significantly influenced by increasing eDNA in primary low pH culture conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
A novel method for visualization of the inferior alveolar nerve for clinical and educational purposes
Publication date: Available online 6 January 2016 Source:Journal of Oral Biosciences Author(s): Joe Iwanaga, Tsuyoshi Saga, Yoko Tabira, Koichi Watanabe, Koh-ichi Yamaki The detailed nervous system in the mandibular bone cannot be observed on computed tomography. Dental professionals need to understand the running route of the inferior alveolar nerve and can do so by using gross anatomical dissection. However, the nervous system is difficult to dissect and visualize clearly because it is surrounded by a hard cortical plate. To develop an educational material for dental professionals, we visualized the inferio...
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research
The function of glucagon-like peptide-1 in the mouse peripheral taste system
Conclusion GLP-1 released from taste cells may be involved in transmission of sweet and lipid signals, thereby impacting animals׳ feeding behavior in response to these important nutrient factors. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 11, 2015 Category: Biomedical Science Source Type: research
Chronic obstructive pulmonary disease and periodontitis – unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease–antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 9, 2015 Category: Biomedical Science Source Type: research
Chronic obstructive pulmonary disease and periodontitis- unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease-antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 4, 2015 Category: Biomedical Science Source Type: research
