Mechanisms of orofacial sensory processing in the rat insular cortex
ConclusionThe insular cortex processes multiple types of sensations from orofacial regions and likely plays a critical role in integrating these sensations with limbic information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Orthodontic tooth movement and HMGB1
ConclusionOrthodontic force modulates HMGB1 expression in PDL fibroblasts, and HMGB1 is an accessory regulator of bone resorption and bone formation during OTM. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Roles of non-canonical Wnt signaling pathways in bone resorption
ConclusionWnt5a and Wnt16 tightly regulate osteoclast differentiation and function in order to maintain bone mass under physiological conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species
ConclusionBacterial pathogens rapidly adapt to clinical intervention, such as antimicrobial agents and vaccination, via horizontal gene transfer, recombination, and/or natural point mutation. It is vital to continue development of innovative analysis methods to counter the mounting threats from evolving bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Epigenetics and its implications for oral health
ConclusionEpigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Elevated concentrations of specific periodontopathic pathogens associated with severe periodontitis in Japanese patients with cardiovascular disease and concomitant obesity
ConclusionsPatients with CVD and concomitant obesity showed more severe periodontitis with increased concentrations of major periodontopathic bacteria than patients without obesity. These bacteria may cause deterioration of CVD and metabolic disorder. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
TGF-β autocrine signaling at secretory-stage enamel
ConclusionLatent TGF-β1 produced and secreted from secretory-stage ameloblasts is activated by MMP20, and the activated TGF-β1 maintains its activity by combining with amelogenin cleavage products processed by the same protease. TGF-β1 moves through the aqueous phase with the water-soluble 13 kDa amelogenin and binds to its receptor on the ameloblast surface, thereby inducing autocrine signaling. Once the ameloblasts differentiate and enter the maturation stage, TGF-β1 is degraded by KLK4, which is produced and secreted by maturation-stage ameloblasts, and loses its activity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research
Effects of salt taste disorder on behavior and lifespan in Drosophila melanogaster
ConclusionsThe results of this study suggest that although NaCl taste disorder results in reduced feeding and breeding behaviors in Drosophila, it does not impact lifespan. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
The temporospatial pattern of energy metabolism coordinates the interactions between the bones and other organ systems
ConclusionStudies on the connections between bones and other organ systems indicate the possible existence of a temporospatial pattern of energy metabolism through the cellular biorhythm and migration. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Comparative gene expression profiles of dental follicle at different stages of periodontal development: Combined use of laser capture microdissection and microarray
ConclusionsThe delineation of the differential gene expressions between pre- and post-natal developmental stages of DF in vivo will increase the understanding of periodontal tissue development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
ConclusionsThe current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15–17, and is composed of resident dental follicle-derived cells and other cell population. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Oral biosciences: The annual review 2017
ConclusionThese reviews in the Journal of Oral Biosciences have inspired its readers to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Free fatty acids may be involved in the pathogenesis of oral-related and cardiovascular diseases
ConclusionIn this review, we summarize a potential link between FFAs and the pathogenesis of craniofacial and cardiovascular diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Mechanisms of orofacial sensory processing in the rat insular cortex
ConclusionThe insular cortex processes multiple types of sensations from orofacial regions and likely plays a critical role in integrating these sensations with limbic information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
Orthodontic tooth movement and HMGB1
ConclusionOrthodontic force modulates HMGB1 expression in PDL fibroblasts, and HMGB1 is an accessory regulator of bone resorption and bone formation during OTM. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 5, 2018 Category: Biomedical Science Source Type: research
