Fluorescence bioimaging of intracellular signaling and its clinical application
Conclusion Technologies that utilize fluorescent proteins, such as the biosensor presented here, should find increasing applications in clinical medicine. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 5, 2016 Category: Biomedical Science Source Type: research
Metalloproteases and CCN2/CTGF in dentin –pulp complex repair
Conclusion In this review, we summarize novel roles for metalloproteases, particularly MMP-3 and BMP-1, in dentin–pulp complex repair, with particular emphasis on the effects of CCN2/CTGF expression during regulation of cell migration and tertiary dentinogenesis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Cell –extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway
Conclusion Signaling pathways initiated by adhesion molecule-mediated crosstalk between tumor cells and extracellular matrices play important roles in driving and maintaining tumor-specific tissue architecture and contributing to tumor survival, growth, and metastasis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Bridging the gap: A regulator of NF- κB linking inflammation and cancer
Conclusion Here, we briefly summarize the known contact points between inflammation and cancer, including oral cancers, and put into context the identification of κB-Ras proteins as molecular link between two independent pathways important for tumor growth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
The downward spiral of periodontitis and diabetes in Alzheimer ׳s disease: Extending healthy life expectancy through oral health
Conclusion Effective management of periodontitis may contribute to prevention of AD, as periodontitis is both treatable and preventable. Therefore, brain health, which includes oral health as a contributing factor, is a promising strategy for achieving healthy life expectancy. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Dental plaque as a biofilm and a microbial community —Implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Chronic obstructive pulmonary disease and periodontitis – unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease–antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Morphological comparison of the enamel –dentine junction and outer enamel surface of molars using a micro-computed tomography technique
Conclusion A detailed comparison of EDJ and OES using µCT will contribute to our understanding of the phylogenetic relationships among fossil records and evolutionary changes in dental characteristics from the developmental perspective. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Fine-tuning between BMP and NF- κB pathways regulates osteoblastic bone formation
Conclusion p65 inhibits BMP2-induced osteoblastic bone formation by interfering with DNA binding of the Smad complex via an interaction with Smad4. Thus, targeting the association between p65 and Smad4 may help promote bone regeneration in the treatment of bone diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Interferon- β produced by osteocytes may negatively regulate osteoclastogenesis
Conclusion We found that osteocytes secrete IFN-β as an inhibitory factor of osteoclastogenesis. Our findings provide a new insight into the mechanisms underlying the osteocytic regulation of bone remodeling. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 17, 2016 Category: Biomedical Science Source Type: research
Three-dimensional imaging of internal tooth structures: applications in dental education
Conclusion Non-invasive, three-dimensional imaging techniques, in particular the various modalities of computed tomography, have ushered in a new era of endodontic studies. Owing to their digital nature, the results derived from these techniques can not only be easily analyzed and distributed but also be rapidly integrated into the teaching materials. Recent studies as well as the data shown in the present contribution suggest that digital educational materials lead to an improved understanding of the complex anatomy of human teeth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 9, 2016 Category: Biomedical Science Source Type: research
Endothelial Cell Transplantation in Tumors Restores Normal Vasculature, Reduces Tumor Hypoxia, and Suppresses Tumor Outgrowth
Conclusion Reconstruction of tumor blood vessels to their normal state alleviated hypoxic conditions and improved the efficiency of drug delivery; the present approach provides a useful model for the development of new cancer therapies. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 9, 2016 Category: Biomedical Science Source Type: research
Interferon-β produced by osteocytes may negatively regulate osteoclastogenesis
Conclusion We found that osteocytes secrete IFN-β as an inhibitory factor of osteoclastogenesis. Our findings provide a new insight into the mechanisms underlying the osteocytic regulation of bone remodeling. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 26, 2016 Category: Biomedical Science Source Type: research
Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination
This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 24, 2016 Category: Biomedical Science Source Type: research
Analytical Methods and Interpretation of Variation in Tooth Morphology
Conclusion Over the past few decades, the morphological data of teeth have been analyzed on the basis of tooth morphology itself as well as from an anthropological perspective. Morphologists should intensify their exchange with molecular biologists and evaluate tooth morphogenesis as well as the genetic basis of tooth structure. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 29, 2016 Category: Biomedical Science Source Type: research
