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Peripheral Sensory Neuropathy in Type 2 Diabetes Patients: A case control study in Accra, Ghana.
Conclusion Our study has shown high burden of PSN in DM patients in Ghana using simple, accurate, non-invasive screening tools like MNSI and neurothesiometer. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 27, 2016 Category: Endocrinology Source Type: research

Management of adynamic bone disease in chronic kidney disease: a brief review
Publication date: Available online 25 July 2016 Source:Journal of Clinical & Translational Endocrinology Author(s): Swathi K. Sista, Seth M. Arum The Kidney Disease: Improving Global Outcomes (KDIGO) work group released recommendations in 2006 to define the bone-related pathology associated with chronic kidney disease as renal osteodystrophy. In 2009, KDIGO released revised clinical practice guidelines which redefined systemic disorders of bone and mineral metabolism due to chronic kidney disease as Chronic Kidney Disease-Mineral and Bone Disorders. Conditions under this overarching term include osteitis fi...
Source: Journal of Clinical and Translational Endocrinology - July 27, 2016 Category: Endocrinology Source Type: research

Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults
Conclusions Lower 25(OH)D concentrations are associated with disturbances in metabolic health in both blacks and whites. Whether correcting vitamin D deficiency could offer a beneficial therapy for disease prevention requires further study. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 27, 2016 Category: Endocrinology Source Type: research

Levothyroxine treatment generates an abnormal uterine contractility patterns in an in  vitro animal model
Conclusion Our data suggest that changes in myometrial reactivity are induced by T4 treatment. Thus, in conjunction with our previous observations on human myometrial strips, management of hypothyroidism should be improved to reduce the rate of C-sections in this group of patients. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 17, 2016 Category: Endocrinology Source Type: research

Pharmacokinetics and pharmacodynamics of insulin glargine –insulin glulisine basal-bolus and twice-daily premixed analog insulin in type 1 diabetes mellitus patients during three standardized meals
Conclusions Glargine/glulisine pharmacokinetics in type 1 diabetes can closely approximate physiologic insulin responses in healthy individuals during a day in which three standardized meals are consumed. Additionally, when glulisine is dosed only five minutes pre-meal, systemic insulin concentration rises as rapidly as prandial endogenous insulin levels. This present study compared glargine and glulisine administered in an approximate 50/50 proportion. Future studies of alternate meal times, meal content and differing premixed insulin preparations are indicated. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 17, 2016 Category: Endocrinology Source Type: research

Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study
Conclusions In this randomized, pilot study, brief administration of TPTD showed anabolic effects that TPTD may help hasten fracture healing in premenopausal women with lower-extremity stress fractures. Larger prospective studies are warranted to determine the effects of TPTD treatment on stress fracture healing in premenopausal women. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 16, 2016 Category: Endocrinology Source Type: research

Ipragliflozin lowers small, dense low-density lipoprotein cholesterol levels in japanese patients with type 2 diabetes mellitus
Conclusions Ipragliflozin may have a potential for lowering sd LDL-C levels associated with increasing LDL particle size in Japanese patients with T2DM. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 15, 2016 Category: Endocrinology Source Type: research

The expanding world of diabetes in this month's JCTE
Publication date: June 2016 Source:Journal of Clinical & Translational Endocrinology, Volume 4 Author(s): Darin E. Olson (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 10, 2016 Category: Endocrinology Source Type: research

“Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study”
Conclusions In this randomized, pilot study, brief administration of TPTD showed anabolic effects that TPTD may help hasten fracture healing in premenopausal women with lower-extremity stress fractures. Larger prospective studies are warranted to determine the effects of TPTD treatment on stress fracture healing in premenopausal women. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 29, 2016 Category: Endocrinology Source Type: research

A practical and evidence-based approach to management of inpatient diabetes in non-critically ill patients and special clinical populations
Publication date: Available online 11 May 2016 Source:Journal of Clinical & Translational Endocrinology Author(s): Aidar R. Gosmanov Inpatient diabetes is a common medical problem encountered in up to 25-30% of hospitalized patients. Several prospective trials showed benefits of structured insulin therapy in managing inpatient hyperglycemia albeit in expense of high hypoglycemia risk. These approaches, however, remain underutilized in hospital practice. In this review, we discuss clinical applications and limitations of current therapeutic strategies. Considerations for glycemic strategies in special clinical...
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research

Effect of a macronutrient preload on blood glucose level and pregnancy outcome in gestational diabetes
Conclusion A macro-nutrient composition, used as a preload is effective in controlling FBG and PBG of gestational diabetes. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research

Beta-cell function and insulin resistance among peruvian adolescents with type 2 diabetes
Conclusion Among Peruvian adolescents with T2D, insulin resistance is the most prominent characteristic, rather than beta-cell dysfunction. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research

High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial
Conclusions In this pilot study, high-dose vitamin D3 safely increased plasma 25(OH)D concentrations into the sufficient range and was associated with decreased hospital length of stay without altering other clinical outcomes. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research

The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome
Conclusions The chlorite component of WF10 is known to inactivate efficiently free cytotoxic hemoglobin forms that might accumulate in peripheral blood after hemolysis and induces the removal of pre-damaged red blood cells from circulation. By these mechanisms WF10 diminished toxic effects of hemolysis, improved microcirculation and glucose consumption in affected tissues, and prevented, thus, below knee amputation. Graphical abstract (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research

The impact of a low glycaemic index (GI) diet on simultaneous measurements of blood glucose and fat oxidation: A whole body calorimetric study
Conclusions Consumption of LGI meals was capable of attenuating 24-hour blood glucose profiles and decreasing postprandial glucose excursions in healthy Asian males. Additionally, LGI mixed meals were able to promote fat oxidation over carbohydrate oxidation when compared to HGI mixed meals. The consumption of low GI meals may be a strategic approach in improving overall glycaemia and increasing fat oxidation in Asians consuming a high carbohydrate diet. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 24, 2016 Category: Endocrinology Source Type: research