Thymic Mucoepidermoid Carcinoma: Report of a Case With CTRC1/3-MALM2 Molecular Studies
We report a CTCR1/3-MAML2 fusion and MAML2 rearrangement–negative TMEC, indicating that a different molecular pathway must be involved in the generation of these tumors. The possibility of fusion-negative TMEC should be taken into consideration in the differential diagnosis of a thymic carcinoma. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Prieto-Granada, C. N., Inagaki, H., Mueller, J. Tags: Molecular Surgical Pathology Source Type: research

Significance of Trophoblastic Infiltration Into the Tubal Wall in Ampullary Pregnancy
In conclusion, serum β-hCG levels are associated with depth of trophoblastic invasion into the tubal wall, severe ischemic changes, and rupture of the tubal wall. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Erol, O., Suren, D., Unal, B., Ozel, D., Kumru, S., Sezer, C. Tags: Original Articles Source Type: research

Concurrent Angiomyolipomas and Renal Cell Neoplasms in Patients Without Tuberous Sclerosis: A Retrospective Study
Synchronous renal cell neoplasms (RCNs) and angiomyolipomas (AML) occurring in the same kidney are rare. The aim of this retrospective study is to investigate the incidence and clinicopathological features of concurrent AML and RCN in patients without tuberous sclerosis complex (TSC). Partial and radical nephrectomy specimens with a diagnosis of RCN and AML from 1995 to May 2013 were reviewed. Cases were assessed for histological subtype of AML and RCN, topographic relationship between the AML and the RCN, and clinical characteristics. A total of 565 RCNs and 19 AMLs were identified. Of 19 cases of AML, 9 (47%) were associ...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Mei, M., Rosen, L. E., Reddy, V., Cimbaluk, D. J., Gattuso, P. Tags: Original Articles Source Type: research

Corrigendum
Su TF, Chao TK, Lee HS, Perng CL, Nieh S. Malignant potential of endometrial stromal tumor with limited infiltration: a case report. Int J Surg Pathol. 2014;22:559-563. Original doi: 10.1177/1066896913506934. The institute name "1National Defense Medical Center, Taipei, Taiwan" on page 559 was incomplete. The correct affiliation of the authors is 1Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Tags: Corrigendum Source Type: research

Prevalence and Importance of Hemosiderin Pigments in Uterine Cervix Stroma
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: AbdullGaffar, B. Tags: Letter to the Editor Source Type: research

Challenges in the differential diagnosis of interdigitating dendritic cell sarcoma of intraparotid lymph node vs. metastatic malignant melanoma with unknown primary site
Interdigitating dendritic cell sarcoma (IDCS) is an uncommon form of malignant histiocytosis affecting dendritic cells. The parotid gland more frequently than other salivary glands has metastasis from extraparotid tumours, which in 80% of cases are melanomas and squamous cell carcinomas. Herein we report our case, a 64-year-old woman who presented with a short history of fluctuating in size swelling below her right ear. Ultrasound scan showed a loculated cystic lesion extending in the parotid parenchyma. Fine needle aspiration (FNA) revealed appearances that were highly suspicious of malignancy, therefore MRI scan was arra...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Galli, F., Petraitiene, V., Muthu, S. K., James, S., Koppana, V. R., Arya, A. Tags: Case Reports Source Type: research

Androgen Receptor-Positive Mucoepidermoid Carcinoma: Case Report and Literature Review
Androgen receptor (AR) is usually expressed in salivary duct carcinoma (SDC), but only infrequently in other carcinoma types including mucoepidermoid carcinoma (MEC). The clinicopathological characteristics of AR-positive MEC remain to be clarified. Here we report a case of AR-positive MEC. A 76-year-old man presented with a growing painless tumor of the right parotid. The resected tumor was a high-grade tumor with necroses. Since the tumor was positive for AR, GCDFP-15, and HER2, SDC was first suspected, but it was also positive for CK5/6 and P63, and negative for S-100 protein and α-smooth muscle actin. In addition...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Ishibashi, K., Ito, Y., Fujii, K., Masaki, A., Beppu, S., Kawakita, D., Ijichi, K., Shimozato, K., Inagaki, H. Tags: Case Reports Source Type: research

Cystic Nephroma/Mixed Epithelial Stromal Tumor: A Benign Neoplasm With Potential for Recurrence
We report a 32-year-old Hispanic woman, with a history of a right, complex cystic, renal mass treated by robotic decortication 2 years ago, who presented with flank pain, hematuria, and recurrent urinary tract infection. A magnetic resonance imaging study showed a 3.4-cm multicystic lesion with thickened septa and enhancement at the right kidney. The partial nephrectomy specimen revealed a well-circumscribed, multicystic tumor abutting the renal pelvis, with thick septa and smooth walls, filled with clear fluid. Microscopic examination showed variably sized cysts lined by cuboidal epithelium with focal hobnailing, without ...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Sun, B. L., Abern, M., Garzon, S., Setty, S. Tags: Case Reports Source Type: research

Xp11 Translocation Renal Cell Carcinoma Morphologically Mimicking Clear Cell-Papillary Renal Cell Carcinoma in an Adult Patient: Report of a Case Expanding the Morphologic Spectrum of Xp11 Translocation Renal Cell Carcinomas
In this report, we discuss differential diagnosis and the diagnostic challenges of Xp11 translocation RCC in adults. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Parihar, A., Tickoo, S. K., Kumar, S., Arora, V. K. Tags: Case Reports Source Type: research

Lung Adenocarcinoma Metastasizing Into a Renal Angiomyolipoma
We report a case of primary lung adenocarcinoma that metastasized into a renal angiomyolipoma 9 years after the resection of primary lung tumor. Comparisons in morphology, immunohistochemical profiles, and genetic mutations indicate that the tumor metastasizing into angiomyolipoma originated from the same clone of previous lung adenocarcinoma. Albeit rare, pathologists should be aware of the possibility of tumor-to-tumor metastasis when confronting a neoplasm exhibiting 2 distinct morphological features. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Wu, P.-S., Pan, C.-C. Tags: Case Reports Source Type: research

Evolution of Microscopic Colitis to Giant Cell Colitis Without Significant Intraepithelial Lymphocytosis or Thickened Collagen Plate
We report the case of a 71-year-old woman complaining of watery diarrhea for several years that was diagnosed with CC. At follow-up, she developed giant cell colitis (GCC). Nine years later, a colectomy revealed a form of microscopic colitis in which significant intraepithelial lymphocytosis and collagen plate thickening have disappeared while GCs persisted with diffuse mononuclear cells inflammation of the lamina propria. Thinning of the collagen plate in association with GCs has been described previously. The case contributes the possibility of further evolution of MC into a pure giant cell colitis in which the prototypi...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: De Petris, G., Chen, L. Tags: Case Reports Source Type: research

Periductal Stromal Sarcoma of the Breast With Liposarcomatous Differentiation: A Case Report With 10-Year Follow-up and Literature Review
A biphasic tumor with features of benign ductal elements and a malignant stromal component that lacks the architecture of a phylloides tumor represents a diagnostic challenge. A 35-year-old woman presented with a painful mass located in the upper inner quadrant of the right breast. A biopsy revealed histologically that the tumor had a multinodular architecture with malignant spindle cells forming cuffs around multiple open benign ducts. No leaf-like architecture was present. In addition, liposarcomatous differentiation was seen in focal areas. Immunohistochemical staining showed positive for CD34, vimentin and CDK4, and ne...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: White, S. R., Auguste, L. J., Guo, H., Bhuiya, T. Tags: Case Reports Source Type: research

An Additional Case of Breast Tumor Resembling the Tall Cell Variant of Papillary Thyroid Carcinoma
A type of breast tumor histopathologically similar to the papillary thyroid carcinoma has been described and named "Breast tumor resembling the tall cell variant of papillary thyroid carcinoma." Because breast is not an uncommon site for metastasis and about 5% of all such cases are of the thyroid origin, it is important to be aware of the existence of mammary tumors that can closely mimic a thyroid tumor representing a dangerous diagnostic pitfall that can also lead to unnecessary clinical investigations. Here, we describe a singular case of "Breast tumor resembling the tall cell variant of papillary thyroid carcinoma" sh...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Colella, R., Guerriero, A., Giansanti, M., Sidoni, A., Bellezza, G. Tags: Case Reports Source Type: research

Primary Peritoneal Clear Cell Carcinoma Versus Ovarian Carcinoma Versus Malignant Transformation of Endometriosis: A Vexing Issue
Peritoneum is a site for both primary and secondary tumors. Primary peritoneal tumors are fairly rare. The most common primary tumors of the peritoneum are malignant mesothelioma and serous papillary adenocarcinoma. Clear cell carcinoma of the peritoneum is extremely rare and often misdiagnosed as mesothelioma, serous carcinoma, or metastatic adenocarcinoma, so it represents a diagnostic challenge for both clinicians and pathologists. Up to date, to the best of our knowledge, only 11 cases of primary peritoneal clear cell carcinoma have been reported in the English literature. Distinguishing this tumor of the peritoneum ve...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Insabato, L., Natella, V., Somma, A., Persico, M., Camera, L., Losito, N. S., Masone, S. Tags: Case Reports Source Type: research

Breast Implant-Associated Anaplastic Large Cell Lymphoma
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Hoda, S., Rao, R., Hoda, R. S. Tags: Images in Pathology Source Type: research