Evolution of Microscopic Colitis to Giant Cell Colitis Without Significant Intraepithelial Lymphocytosis or Thickened Collagen Plate

We report the case of a 71-year-old woman complaining of watery diarrhea for several years that was diagnosed with CC. At follow-up, she developed giant cell colitis (GCC). Nine years later, a colectomy revealed a form of microscopic colitis in which significant intraepithelial lymphocytosis and collagen plate thickening have disappeared while GCs persisted with diffuse mononuclear cells inflammation of the lamina propria. Thinning of the collagen plate in association with GCs has been described previously. The case contributes the possibility of further evolution of MC into a pure giant cell colitis in which the prototypical manifestations of MC have all but disappeared.

Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: De Petris, G., Chen, L. Tags: Case Reports Source Type: research