Extrauterine Epithelioid Trophoblastic Tumor Arising in the Ovary With Multiple Metastases: A Case Report
We report a case of a 50-year-old woman who presented with abdominal pain and distension. Her initial β-human chorionic gonatotropin level was 806.7 IU/L. Imaging showed a large complex ovarian mass with peritoneal and subcapsular hepatic deposits as well as pulmonary nodules. Morphological features of the tumor and its immunohistochemical reactivity to CK8/18, CK7, p63, and CD10 were consistent with the diagnosis of an extrauterine epithelioid trophoblastic tumor arising from the ovary. The differential diagnoses, including other ovarian tumors, were ruled out on the basis of morphology and negative immunostaining to...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Arafah, M. A., Tulbah, A. M., Al-Husaini, H., Al-Sabban, M., Al-Shankiti, H., Al-Badawi, I. A. Tags: Case Reports Source Type: research

Ovarian Immature Teratoma With Gliomatosis Peritonei and Pleural Glial Implant: A Case Report
We present a case of ovarian immature teratoma with both gliomatosis peritonei and pleural glial implant in a 4-year-old girl. Glial emboli were present in the pleural implant, suggesting lymphovascular dissemination might be the cause of extra-abdominal glial implantation. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Wu, P.-S., Lai, C.-R. Tags: Case Reports Source Type: research

Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule
In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Xue, D., Li, X., Ren, Y., Liu, Q., Yen, Y., Xue, L. Tags: Case Reports Source Type: research

Anal Melanoma With Neuroendocrine Differentiation: Report of a Case
Melanoma of the anal cavity is an uncommon malignant tumor with an aggressive clinical behavior. The presence of nonmelanocytic cell or tissue components, designated as divergent differentiation, is an unusual but well-documented phenomenon in melanoma. We experienced a rare case of amelanotic melanoma with neuroendocrine differentiation of the anal canal, occurring in a 68-year old woman. This tumor was characterized by a clear-cut radial growth phase and an invasive component composed of a diffuse small cells population positive for neuroendocrine markers with a focal but convincing co-expression of S100 protein. To the ...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Ilardi, G., Caroppo, D., Varricchio, S., Vita, G., Di Lorenzo, P., Insabato, L., De Rosa, G., Mascolo, M. Tags: Case Reports Source Type: research

Concomitant Pseudomembranous Colitis in Colonic Resection for Acute Diverticulitis
Diverticulitis and Clostridium difficile infection (CDI) are common conditions in the surgical population. However, they are usually 2 distinct clinical entities. Here, we report the case of acute diverticulitis with concomitant pseudomembranous colitis, presumably due to CDI. The clinical course as well as gross and microscopic pathology findings are discussed. A literature search revealed a single previous report of these findings concomitant in a surgical specimen. A brief discussion of the pathophysiology of CDI and acute diverticulitis is included. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Byrns, S., Canterbury, L. A. Tags: Case Reports Source Type: research

Diaphragm Disease of the Small Intestine: An Interesting Case Report
Diaphragm disease of small intestine usually presents with nonspecific clinical features. Radiological investigations often fail to differentiate it from small intestinal tumors and inflammatory bowel disease. It is therefore diagnosed on final histology after surgical resection. We hereby report an interesting case of a suspected small bowel tumor later diagnosed as diaphragm disease on histology. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Ullah, S., Ajab, S., Rao, R., Raghunathan, G., DaCosta, P. Tags: Case Reports Source Type: research

Late Hepatic Metastasis From a Duodenal Gastrointestinal Stromal Tumor (29 Years After Surgery): Report of a Case and Review of the Literature
We report a case of a man with a giant liver mass at computed tomography scan. In September 1984, the patient had undergone resection of a duodenal tumor, diagnosed as schwannoma. A liver biopsy revealed a neoplasm composed of epithelioid and spindled cells, immunohistochemically positive to c-kit and Dog-1. Reexamining the duodenal tumor resected in 1984, it was reclassified as GIST. Sequencing revealed the same mutation of the c-kit gene in both duodenal and hepatic lesions. To the best of our knowledge, this case represents the longest disease-free interval between a primary GIST and its metastasis. A brief review of th...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Ginori, A., Scaramuzzino, F., Marsili, S., Tripodi, S. Tags: Case Reports Source Type: research

Gastric Inverted Hyperplasic Polyp Composed Only of Pyloric Glands: A Rare Case Report and Review of the Literature
This report describes a case of a 70-year-old man with gastric IHP, composed only of pyloric-type gland. It was removed completely by endoscopic submucosal dissection, and patient showed no recurrence over 2 years after treatment. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Jung, M., Min, K.-W., Ryu, Y.-J. Tags: Case Reports Source Type: research

Malakoplakia of the Thyroid Gland: A Case Report and Review of Literature
We present an exceedingly rare case of malakoplakia of the thyroid in a 54-year-old Caucasian woman on immunosuppressive therapy for renal transplant performed in 1994. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Vitkovski, T., Costales, C., Chen, S., Saltman, B., Kahn, L. Tags: Case Reports Source Type: research

Papillary Thyroid Carcinoma With Nodular Fasciitis-Like Stroma: A Usual Entity With Distinctive Morphology
We report a case of PTC-NFS, a tumor characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of conventional PTC. We review the literature on this rare variant, discuss the importance of a thorough search for epithelial components within any fibroproliferative lesion of the thyroid, and address the diagnostic difficulties created by the tumor’s extensive stromal component. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Ginter, P. S., Scognamiglio, T. Tags: Case Reports Source Type: research

Recurrent Ameloblastoma of the Mandible With Unusual Granular Cell Component
Ameloblastomas can present in various clinical and histomorphologic patterns. The granular cell variant accounts for only 3.5% to 5% of ameloblastomas. The aim of this case report is to present an example of ameloblastoma with unusual granular cell component, affecting a 63-year-old woman, in which both the inner and peripheral layers of follicles composed exclusively by eosinophilic granular cells. Assessment of the immunohistochemical and histochemical profile of the lesion was performed and the challenges of such a diagnosis were also addressed. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Argyris, P. P., McBeain, M. J. T., Rake, A., Pambuccian, S. E., Gopalakrishnan, R., Koutlas, I. G. Tags: Case Reports Source Type: research

Myxoinflammatory Fibroblastic Sarcoma of the Scalp: Aggressive Behavior at a Rare, Nonextremity Site
We describe a case of MIFS occurring as a primary neoplasm on the scalp of an 80-year-old male, which recurred locally after 2 years and developed extensive bilateral cervical lymph node metastases. MIFS is exceptionally rare in the head and neck, and it has been described only once on the scalp. This case showed classical histologic features, and additionally a high mitotic index and atypical mitoses, which may be suggestive of a poorer prognosis. This case highlights the need to consider MIFS in the differential diagnoses of pleomorphic tumors of the head and neck, and it adds to the small number of MIFS showing highly a...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Vroobel, K., Miah, A., Fisher, C., Thway, K. Tags: Case Reports Source Type: research

Pancreatobiliary Intraductal Papillary Neoplasms: What Is in a Name?
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Grillo, F., Guadagno, A., Rimini, E., Minetti, G., Mastracci, L. Tags: Images in Pathology Source Type: research

Tissue Love Symbols
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Lambropoulou, M., Pasadakis, P., Papadopoulos, N. Tags: Images in Pathology Source Type: research

Epithelioid Mammary Myofibroblastoma Mimicking Invasive Lobular Carcinoma
A case of a 53-year-old woman with the epithelioid variant of mammary myofibroblastoma, which was initially misinterpreted as invasive lobular carcinoma, is presented. A needle core biopsy of the 1.6 cm mass showed interlacing bundles of epithelioid myofibroblasts amid dense fibrous tissue associated with lobular carcinoma in situ of the classical type. Most epithelioid cells showed nuclear atypia, and a few exhibited signet-ring cytology. Immunoreactivity for estrogen and progesterone receptors further compounded the deception, and the neoplasm was misinterpreted as invasive lobular carcinoma. Excisional biopsy showed a c...
Source: International Journal of Surgical Pathology - May 12, 2015 Category: Pathology Authors: Arafah, M. A., Ginter, P. S., D'Alfonso, T. M., Hoda, S. A. Tags: Pitfalls in Pathology Source Type: research