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Exuberant Squamous Metaplasia in an Intraductal Papilloma of Breast
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Ginter, P. S., Hoda, S. A., Ozerdem, U. Tags: Images in Pathology Source Type: research

Intraabdominal Splenosis
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Jahanshir, A., Bahreini, M., Mirfazaelian, H., Aledavood, A., Negahban, S., Daneshbod, Y. Tags: Images in Pathology Source Type: research

"Baby Runner" From the Placenta
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Lambropoulou, M. Tags: Images in Pathology Source Type: research

Carcinosarcoma of the Parotid: Investigating Its Biology With Morphoproteomics
We report a case of a 55-year-old Caucasian man who presented with a progressively enlarging left facial mass. Histopathological evaluation of the tumoral tissue revealed a high grade, mixed epithelial and mesenchymal malignant tumor, most consistent with a carcinosarcoma of the parotid. Morphoproteomic analysis was performed and revealed expression of secreted protein acidic and rich in cysteine (SPARC); glioma-associated oncogen protein 2 (Gli2); and phosphorylated signal transducer and activator of transcription (p-STAT3 [Tyr705]) in the carcinomatous and malignant mesenchymal components. These aforementioned markers ha...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Velez-Perez, A., Huang, R. S. P., Everett, J. M., Guo, S., Buryanek, J., Karni, R. J., Brown, R. E. Tags: Molecular Pathology Source Type: research

Variations in Molecular Profile in NSCLC Can Be Analyzed Using Cytological Samples: Development of EGFR Resistance Mutations and Coexistence of ALK-EML4 Translocation in an EGFR-Sensitive Patient
We report a case of a non–small cell lung carcinoma patient with coexistence of EGFR mutations and ALK-EML4 rearrangements that responded to EGFR inhibitors and in which the development of a new resistance mutation in exon 20 of EGFR-determined treatment resistance. All the molecular determinations were performed in cytological samples. To our knowledge, this is the first case reported with these characteristics, and the 11th case described with coexistence of EGFR mutations and ALK-EML4 rearrangements. The EGFR L858R mutation in exon 21 was found at diagnosis, and the patient presented a 4-year response to erlotinib...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Lozano, M. D., Labiano, T., Zudaire, I., Subtil, J. C., Gurpide, A., Echeveste, J. I., Zulueta, J. J., Martin-Algarra, S., Perez-Gracia, J. L. Tags: Molecular Pathology Source Type: research

Tumor Budding Is an Independent Prognostic Factor for Prediction of Lymph Node Metastasis in Oral Squamous Cell Carcinoma
Conclusion. Tumor budding is frequently encountered histologic marker in OSCC. High-intensity tumor budding is a strong independent prognostic factor for prediction of lymph node metastasis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Angadi, P. V., Patil, P. V., Hallikeri, K., Mallapur, M. D., Hallikerimath, S., Kale, A. D. Tags: Original Articles Source Type: research

Editorial
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Fisher, C. Tags: Editorial Source Type: research

Thread-Like Bridging Strands in the Adenomatoid Tumor of the Small Intestine
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Kokoskova, B., Daum, O. Tags: Letters to the Editor Source Type: research

Diagnosing Sarcomatoid Carcinoma and Carcinosarcoma of the Large Bowel: Heads or Tails?
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Virgilio, E., Mercantini, P., Tarantino, G., Masyuk, M., La Gumina, G., Ziparo, V. Tags: Letters to the Editor Source Type: research

Hyaline Globules in Mammary Myofibroblastoma: A Case Report
A 52-year-old otherwise healthy woman presented with a solitary firm mass in the right breast. Histopathological evaluation of the 1.5-cm mass showed a mammary myofibroblastoma of the conventional spindle-cell type. High-power examination of hematoxylin–eosin-stained sections showed round, eosinophilic, intracytoplasmic, as well as extracellular, hyaline globules. These 5- to 20-µm globules appeared gray with a pinkish rim on Masson’s trichrome stain. Immunohistochemically, the hyaline globules were strongly reactive with smooth muscle myosin heavy chain, desmin, and caldesmon. Histologically similar incl...
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Ozerdem, U., Wells, J., Hoda, S. A. Tags: Case Reports Source Type: research

A Case Report: Blastic Plasmacytoid Dendritic Cell Neoplasm Is Misdiagnosed as Breast Infiltrating Ductal Carcinoma
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic tumor that typically occurs in older adults. Patients with BPDCN usually present with solitary or multiple skin lesions. Localized or disseminated lymphadenopathy at presentation is common. A case report illustrating histopathologically proven BPDCN initially misdiagnosed as breast infiltrating ductal carcinoma in a 39-year-old woman is presented. In this case, the patient presented with a breast mass without an obvious skin lesion initially. The morphology of the tumor cells mimicked high grade breast carcinoma cells. Without complet...
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Chen, K.-C., Su, T.-C., Chen, D.-R., Liou, J.-H. Tags: Case Reports Source Type: research

Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: Description of a Case With an Unexpected Clinical Outcome
Anaplastic lymphoma kinase–positive (ALK-positive) large B-cell lymphoma is a rare and aggressive variant of large B-cell lymphoma (LBCL), first reported by Delsol et al in 1997, showing distinctive morphologic, immunophenotypic and cytogenetic features. The latest 2008 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid tissues recognizes ALK-positive LBCL as a separate entity. Here, we report a case of ALK-positive large B-cell lymphoma in a 53-year-old man with diffuse abdominal and mediastinal lymph-nodes involvement. According to the Ann Arbor staging system, the patient had a stag...
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Zanelli, M., Valli, R., Capodanno, I., Ragazzi, M., Ascani, S. Tags: Case Reports Source Type: research

A Leukemic Presentation of Alveolar Rhabdomyosarcoma in a 52-Year-Old Woman Without an Identifiable Primary Tumor
A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonst...
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Kern, J. B., Hii, A., Kruse, M. J., Szabo, Z., Argani, P., Hibbard, M. K., Gladstone, D. E., Meyer, C., Zheng, R., Borowitz, M. J., Duffield, A. S. Tags: Case Reports Source Type: research

Soft Tissue Giant Cell Tumor of Low Malignant Potential of Mediastinum: A Rare Case Report
Giant cell tumor (GCT) is primarily a bone neoplasm. Rare origin of the tumor from soft tissues has been reported. Involvement of mediastinum by GCT is even rarer. We herein describe an interesting case of huge mediastinal tumor in a young man. Radiologically, no primary osseous lesion was present throughout the body. Morphologically, tumor resembles osseous GCT with increased mitotic activity. Hence, the case was diagnosed as soft tissue GCT of low malignant potential at the rare site of mediastinum. To the best of our knowledge, the present case is the fourth reported case. Pathologists and clinicians need to be aware of...
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Jain, D., Arava, S., Mishra, B., Sharma, S., Sharma, R., Parshad, R. Tags: Case Reports Source Type: research

A Rare Complication of Gastric Bypass (Weight Loss) Surgery: Nesidioblastosis
Here, we present the case of a 31-year-old woman patient who underwent distal pancreatectomy with the history of gastric bypass surgery for obesity. The final histopathological diagnosis of the lesion was nesidioblastosis. Nesidioblastosis is the most common cause of organic persistent hyperinsulinemic hypoglycemia in newborns; however, it is rare in adults. In adults, it is difficult to diagnose nesidioblastosis with only clinical findings. The definitive diagnosis of the disease depends on the histopathological examination of pancreatic tissue and the exclusion of insulinoma. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 7, 2015 Category: Pathology Authors: Unal, B., Uzun, O. C., Başsorgun, C. I., Erdoğan, O., Elpek, G. O. Tags: Case Reports Source Type: research