International Journal of Surgical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Benign Monsters
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Sancheti, S. M., Midha, D., Zameer, M. A. L., Arun, I. Tags: Images in Pathology Source Type: research

Novel Technique of Sampling the Urinary Bladder for Urothelial Carcinoma Specimens
Sampling of the urinary bladder (UB) in radical cystectomy specimens is usually performed by obtaining sections through the lesions taken in rather random planes. The technique is hindered by the difficulty in identifying the anatomical relationship of the tumor with the remaining urinary bladder. Fifty radical cystectomy specimens were bisected in the horizontal plane at the middle portion of the UB then fixed without tissue stretching in 10% buffered formalin for at least 24 hours. The UBs were serially sectioned in parallel horizontal planes from the UB neck to the dome into rings of 3 to 10 mm thickness. The sections w...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Mai, K. T., Ball, C. G., Swift, J., A. Flood, T., Belanger, E. C. Tags: Techniques in Pathology Source Type: research

Intra-Alveolar Intestinal Epithelium: A Reappraisal of the So-Called Mucinous Goblet-Cell Rich Carcinoma Apropos of Two Cases With Prolonged Follow-up and Literature Review
Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuous patches of nonatypical colonic type epithelium attached to alveolar walls without evidence of invasion. Immunohistochemically, these epithelial patches express an intestinal immunophenotype (CD20+, CDX-2+, CK7–, TTF-1–). None of the lesions so far reported with these histological and immunohistoc...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Jessurun, J. Tags: Original Articles Source Type: research

Histopathology of Disseminated Mycobacterium bovis Infection Complicating Intravesical BCG Immunotherapy for Urothelial Carcinoma
We report 3 additional cases of BCG-osis complicating BCG therapy, all confirmed by cultures and molecular assays, including the first cases of wedge biopsy-confirmed BCG pneumonia and BCG olecranon bursitis. When suggested by a relevant clinical history, recognition of randomly distributed granulomas in any organ should prompt consideration of BCG-osis and liberal performance of AFB stains, aided by targeted molecular assays. Physicians should maintain a high index of suspicion when miliary infiltrates arise after intravesical BCG instillation, and close multidisciplinary communication is essential. Pathologist awareness ...
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Larsen, B. T., Smith, M. L., Grys, T. E., Vikram, H. R., Colby, T. V. Tags: Original Articles Source Type: research

Clinical and Histopathological Diagnosis of Glomus Tumor: An Institutional Experience of 138 Cases
Discussion. Our study illustrates trends in the clinical versus pathologic diagnoses of glomus tumor, common competing diagnoses, a difference in demographics than is commonly reported (older age groups most commonly affected), and important differences in the use adjunctive diagnostic tools including radiology and immunohistochemistry. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 29, 2015 Category: Pathology Authors: Mravic, M., LaChaud, G., Nguyen, A., Scott, M. A., Dry, S. M., James, A. W. Tags: Review Source Type: research

Ectopic Thyroid Tissue in the Adrenal Gland: Report of a Case
We present the case of a 32-year-old woman with ectopic thyroid parenchyma in the adrenal gland. Clinically, postoperative thyroid ultrasound echography and computed tomography scans did not reveal any thyroid tumor. The ectopic tissue was a cyst bordered by mature follicular thyroid structures and was histologically benign, without the molecular alterations associated with malignant tumors of follicular cell derivation (BRAFV600E, N-RAS, H-RAS, K-RAS). Review of the literature reveals that adrenal ectopic thyroid tissue is nearly always cystic and has distinctive pathologic features. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Casadei, G. P., Bertarelli, C., Giorgini, E., Cremonini, N., de Biase, D., Tallini, G. Tags: Case Reports Source Type: research

Enterocolic Lymphocytic Phlebitis as a Newly Recognized Manifestation of IgG4-Related Disease
Herein we present a case of a 65-year-old woman with enterocolic lymphocytic phlebitis (ELP) who presented with anemic syndrome and in whom severe stenosis of the right flexure of large bowel was detected. The microscopic examination revealed fibrosis of the submucosa and lymphoplasmacytic phlebitis of small veins and venules, whereas arteries were spared. There were 110 IgG4-positive and 160 IgG-positive plasma cells in 1 high-power field, respectively, with corresponding IgG4/IgG ratio of 0.69. The IgG4 serum level was 2.42 g/L. According to the currently proposed criteria, this ELP case is the first that may be diagnose...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Laco, J., Orhalmi, J., Bartova, J., Zimandlova, D. Tags: Case Reports Source Type: research

Primary Cutaneous Mucoepidermoid Carcinoma: A Case Study With a Review of the Literature
We report a case of MEC of the skin in a 76-year-old man who presented with an infiltrative multinodular lesion on his right cheek. Histological description showed a multilobulated nodulocystic tumor extending throughout the dermis exhibiting glandular and squamoid differentiation. Cribiform nests of epidermoid cells contained glandular spaces with mucin. The nuclei were mildly atypical and contained scattered mitotic figures. A small focus of perineural invasion was evident within the tumor not extending beyond the deep margin with no lymphovascular invasion. There was no overlying intraepidermal carcinoma. Immunohistoche...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Gartrell, R., Pauli, J., Zonta, M. Tags: Case Reports Source Type: research

Metachronous Bilateral Testicular Seminoma Developing After an Interval of 31 Years: Case Report and Review of the Literature
Men diagnosed with testicular germ cell tumors are at higher risk for development of a second germ cell tumor in the contralateral testis. Metachronous bilateral testicular germ cell tumors usually occur within 5 years. Here, we report a case of a 63-year-old man previously diagnosed with testicular seminoma and treated with a left orchiectomy followed by radiation, developing contralateral testicular seminoma after an interval of 31 years. The patient was asymptomatic and found to have an enlarged, nontender right testis on routine urological examination. Further workup did not reveal evidence of metastatic disease or lym...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Sun, B. L., Pearl, R., Sharifi, R., Guzman, G. Tags: Case Reports Source Type: research

Metachronous Myxofibrosarcoma and Osteosarcoma: Case Report and Review of the Literature
We report a case of a 62-year-old man who developed 2 histologically distinct sarcomas: a soft tissue myxofibrosarcoma and vertebral osteosarcoma. This unusual case highlights the critical role of careful histopathological evaluation in distinguishing synchronous or metachronous neoplasia from metastatic tumor. To the best of the authors’ knowledge, this is the first reported case of metachronous soft tissue myxofibrosarcoma and osteosarcoma. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Caffrey, R., Robinson, A. J., Shukla, S., McCarty, H., Brown, A., Houghton, O. P. Tags: Case Reports Source Type: research

Sclerosing Muc-4-Positive Sarcoma With Glandular Differentiation Resembling Sclerosing Epithelioid Fibrosarcoma
We present a case of a 52-year-old female who presented with a sclerosing Muc-4-positive sarcoma with glandular differentiation of the sciatic nerve, resembling sclerosing epithelioid fibrosarcoma. The glandular component showed strong expression of keratin and EMA and ultrastructurally showed numerous intercellular junctions and intraluminal microvilli, supportive of true glandular differentiation. The patient received preoperative radiotherapy (50 Gray) and subsequent resection of the mass with negative margins. She is currently disease free at 20-month follow-up. This case report describes an unusual sclerosing Muc-4-po...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Chebib, I., Desphande, V., Nielsen, G. P. Tags: Case Reports Source Type: research

Clear Cell Adenocarcinoma Arising in an Adenomyoma of the Broad Ligament
Extrauterine adenomyomas are extremely rare benign tumors of smooth muscles, endometrial glands, and endometrial stroma. Ectopic endometrial glands can undergo malignant change. The ovary is the most common site of malignant change in endometriosis. Cancer arising in extraovarian endometriosis is a rare event with limited cases in the literature. To the best of our knowledge, we present the first case of a clear cell adenocarcinoma arising from foci of ectopic endometrial tissue in an adenomyoma of the broad ligament. It supports the association between endometriomas and clear cell adenocarcinoma. Therefore, patients with ...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Torres, D., Parker, L., Moghadamfalahi, M., Sanders, M. A., Metzinger, D. S. Tags: Case Reports Source Type: research

Hepatic Uterus-Like Mass Misdiagnosed as Hepatic Abscess
Conclusion. This rare case illustrates the merit of considering uterus-like mass/endometriosis in the differential diagnosis of antibiotic-refractory hepatic cysts. Cyst heterogeneity may confound needle biopsy. We report the first instance of a hepatic uterus-like mass, with a review of related entities, postulated histogenesis, and important clinical associations. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Sopha, S. C., Rosado, F. G. N., Smith, J. J., Merchant, N. B., Shi, C. Tags: Case Reports Source Type: research

Ovarian Paraganglioma
A rare case of ovarian paraganglioma was incidentally found as a 1.2-cm intraovarian mass in a 68-year-old hypertensive female operated for an endometrial carcinoma. Histologically, it was arranged in characteristic Zellballen composed of polygonal clear cells with a granular cytoplasm that expressed diffusely CAM5.2 cytokeratin, chromogranin, neuron-specific enolase, synaptophysin, and CD56, while S-100 protein was only present in sustentacular cells. We analyzed differential diagnoses with other rare ovarian tumors such as Sertoli cell tumor, with which it may share an immunophenotype expressing cytokeratins, S-100, and ...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Schuldt, M., Retamero, J. A., Tourne, M., Nogales, F. F. Tags: Case Reports Source Type: research

Prominent In Situ Component in a Pleural Malignant Mesothelioma
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Bono, F., Lombardi, M. Tags: Images in Pathology Source Type: research