International Journal of Surgical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Coexistence of Malakoplakia and Papillary Urothelial Carcinoma of the Urinary Bladder
Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract, with the urinary bladder being the most frequently affected site. Grossly, malakoplakia can present as soft yellow plaques, nodules, bladder mass, or even without any visible lesion. In this article, we present a 74-year-old female with a background of hypertension, hyperlipidemia, and poorly controlled diabetes who presented with sepsis of unknown origin. During the course of the investigation of the source of her sepsis, an incidental bladder tumor was discovered. She subsequently underwent transurethral resection of the bladder ...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Lee, S. L. J., Teo, J. K., Lim, S. K. T., Salkade, H. P., Mancer, K. Tags: Case Reports Source Type: research

A Wolf in Sheep's Clothing: A Sporadic Juvenile Polyp of the Colon Harboring an Intramucosal Adenocarcinoma
We describe a solitary peduncolated polypoid lesion with a bilobated head in the transverse colon mucosa of a 51-year-old Caucasian man. Histologically, the lesion was consistent with juvenile polyp (JP), but showing a few dysplastic glands and a focus of intramucosal adenocarcinoma. This finding suggests that, at least in adults, even the sporadic JPs might carry an inherent potential for malignancy, which has so far only been pointed out for syndromic lesions. Additionally, we observed p53 overexpression in both the dysplastic lesions and in the invasive cells but not in the remaining epithelium. We can argue that p53 im...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Vanoli, A., Lucioni, M., Biletta, E., Chiaravalli, A. M., Alvisi, C., Luinetti, O. Tags: Case Reports Source Type: research

Jejunal Metastasis Colliding With a Borderline Tumor in the Ovary: A Hitherto Unreported Eventuality
Metastatic adenocarcinomas to the ovary can show morphologically innocuous areas simulating primary benign lesions or borderline tumors. Ruling out a metastasis can be a difficult issue for pathologists, especially when facing with cystic tumors. Because of the important clinical implications of differentiating metastatic adenocarcinomas from primary ovarian tumors, the integration of clinical, pathological, and immunohistochemical features is warranted, primarily in case of mucinous adenocarcinomas. Vice versa, the synchronous presence of a metastasis and a primary in the same ovary is virtually excluded as a very unlikel...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Piana, S., Giunta, A., Valli, R. Tags: Case Reports Source Type: research

Gangliocytic Paraganglioma With Atypical Immunohistochemical Features Presenting as Extrahepatic Biliary Obstruction
Gangliocytic paraganglioma is a rare benign tumor of upper gastrointestinal tract that most commonly involves the second part of duodenum. The tumor is detected incidentally on imaging in most of the cases. However, presentation with extrahepatic biliary obstruction is extremely rare. We recently encountered a 50-year-old male patient who was evaluated for extrahepatic biliary obstruction and was found to have a periampullary mass on imaging. The patient underwent pylorus-preserving pancreaticoduodenectomy along with liver biopsy and hepatoduodenal lymph node dissection. On histopathological examination, a tumor was detect...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Sharma, S., Gaspar, B. L., Kumar, P., Yadav, T. D., Vasishta, R. K. Tags: Case Reports Source Type: research

Thymic Tumor With Adenoid Cystic Carcinoma-Like Features: A Study of a Clinically Favorable Case Followed for 9 Years
We present a case of a noninvasive cribriform tumor that was followed, including a 4-year period after tumor resection and radiation therapy, for a total of 9 years. The tumor was purely epithelial. It was positive for keratins (AE-1/AE-3, CK19, 34βE12,CK5/6), MOC-31, P63, P40, CD10, and MYB, and was negative for myoepithelial or neuroendocrine markers. Presence of cell processes, desmosome-like junctions with tonofilaments and multifocally reduplicated basal lamina was noted on ultrastructural examination. Two signals of the MYB gene per cell were detected by fluorescence in situ hybridization. No monosomy or translo...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Rampisela, D., Zreik, R., Donner, L. R. Tags: Case Reports Source Type: research

Myeloid Sarcoma Masquerading as Granulation Tissue: A Diagnostic Pitfall
This report describes a case of a painful back lump in an elderly Chinese male, which was initially diagnosed as a carbuncle. Histology on the saucerization specimen was reported as inflamed granulation tissue. Failure of expected wound healing prompted surgical debridement; microscopic examination on the subsequent specimen revealed an immature myeloid population with an increased MIB-1 proliferative index, highlighted by myeloperoxidase, lysozyme, CD117, and CD43 immunoreactivity, in keeping with myeloid sarcoma. Despite aggressive management, the patient eventually died. This report draws attention to potential pitfalls...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Tan, Y. B. Tags: Pitfalls in Pathology Source Type: research

A Note of Caution: Variable Cytokeratin Staining in Sentinel Node Metastases
We report 2 cases of metastatic carcinoma demonstrating negative staining for AE1/AE3. This observation highlights a rare but potential pitfall to this commonly used strategy in assessing sentinel lymph node biopsies in breast cancer. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Zeng, J., Alexander, M. A., Nimeh, D., Darvishian, F. Tags: Pitfalls in Pathology Source Type: research

p16 Expression in Fat Necrosis: A Potential Diagnostic Pitfall in the Evaluation of Differentiated Adipocytic Neoplasms
We describe a case of a large retroperitoneal adipocytic mass occurring in a 27-year-old male, which was clinically and radiologically in keeping with WDL. Histologically this was a differentiated adipocytic neoplasm with prominent fibrous septa and fat necrosis, more suggestive of retroperitoneal lipoma. Immunohistochemistry showed diffuse, strong nuclear expression of p16 in the areas of fat necrosis. However, CDK4 was negative and the lesion lacked evidence of MDM2 amplification with FISH. Diffuse expression of p16 in areas of fat necrosis in large or deep lipomas highlights the potential for diagnostic misinterpretatio...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Ng, W., Messiou, C., Smith, M., Thway, K. Tags: Pitfalls in Pathology Source Type: research

Mammary Lymphangioma
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Arafah, M., Sweet, G., Ginter, P. S., Hoda, S. A. Tags: Images in Pathology Source Type: research

{alpha}-Fetoprotein-Producing Hepatoid Gastric Adenocarcinoma With Osteoclast-Like Giant Cells and Neuroendocrine Differentiation: A Case Study With Molecular Profiling
Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and α-fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma with osteoclast-like giant cells (OGCs). The cancer was HER2 and E-cadherin negative, chromogranin A dispersedly and moderately positive, and strongly α-fetoprotein-positive with evident CK AE1/AE3 immunoreactivity, while OGCs expressed CD68. To provide an insight into the molecular background of t...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Wincewicz, A., Kowalik, A., Zieba, S., Lewitowicz, P., Gozdz, S., Sulkowski, S. Tags: Molecular Surgical Pathology Source Type: research

Hepatobiliary IgG4 Cholangiopathy: Case Series and Literature Review
We present the clinicopathological spectrum of a retrospective series of 6 cases of IgG4 cholangiopathy that clinically masqueraded as hepatobiliary malignancies. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Rastogi, A., Bihari, C., Grover, S., Rajbongshi, A., Arora, A., Nikhil, N., Pamecha, V., Sarin, S. K. Tags: Original Articles Source Type: research

Early Stages of Hyaline Membrane Formation Detected in Alveolar Mouths in Diffuse Alveolar-Damage-Associated Diseases: A Detailed Immunohistochemical Study
To study the early stages of hyaline membrane (HM) formation, diffuse alveolar damage (DAD) was thoroughly investigated using immunohistochemical methods in 15 autopsy cases, which consisted of various types of interstitial pneumonias and pulmonary diseases derived from nonmalignant or malignant diseases. Alveolar mouths (AMs) that were presumed to be normal were ultrastructurally examined in detail, by using pulmonary tissues in the pneumothorax. It is interesting to note that during the initial stages of HM formation in AMs, fragmented eosinophilic masses were closely attached to AMs as irregular fragments or by a cap-li...
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Ohtsuki, Y., Fujita, J., Yoshinouchi, T., Enzan, H., Iguchi, M., Lee, G.-H., Furihata, M. Tags: Original Articles Source Type: research

Bladder Neck Urothelial Carcinoma: A Urinary Bladder Subsite Carcinoma With Distinct Clinicopathology
In conclusion, BNCs present with a significantly higher frequency of muscle invasion and advanced tumor stage, lymphovascular invasion, as well as local and distant metastasis at diagnosis compared with the non-BNCs group. Recognition of these unique clinicopathologic features with early detection and possibly more aggressive management of BNC can potentially have a significant impact on the patient’s outcome. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 31, 2015 Category: Pathology Authors: Xiao, G.-Q., Rashid, H. Tags: Original Articles Source Type: research

Gastric Malignant Peripheral Nerve Sheath Tumor: A Case Report
Gastric malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas arising within a peripheral nerve. Gastric MPNSTs are extremely rare with only a few cases. We herein describe the case of a 48-year-old man with a gastric MPNST for the first time in Korea, which was diagnosed histopathologically after surgery. The patient underwent curative subtotal gastrectomy with D1+ lymph node dissection and Billroth-II reconstruction. The postoperative recovery was uneventful, and he has had no recurrence until now. The ideal adjuvant treatment protocol is yet to be decided due to the relatively limited number of cases of these t...
Source: International Journal of Surgical Pathology - August 6, 2015 Category: Pathology Authors: Kim, E. Y., Lee, S. H., Yoo, H. M., Song, K. Y., Park, C. H. Tags: Case Reports Source Type: research

Molecular Confirmation of Ewing Sarcoma in an 85-Year-Old Woman
We report a case of a Ewing sarcoma/primitive neuroectodermal tumor in an 85-year-old woman who presented with an enlarging circumscribed left flank mass. Magnetic resonance imaging revealed a 3 x 5 x 10 cm heterogeneous mass arising from the 10th rib. Computed tomography demonstrated a small nodule in the right middle lobe and bilateral pleural effusions. The patient underwent computed tomography–guided biopsy followed by open biopsy. The tumor cells were characterized by loosely cohesive sheets of tumor cells with uniform nuclei, and scant, granular, eosinophilic cytoplasm with indistinct cell membranes. Frequent m...
Source: International Journal of Surgical Pathology - August 6, 2015 Category: Pathology Authors: Monument, M. J., Grossmann, A. H., Baker, C. C., Randall, R. L., Liu, T., Albertson, D. J. Tags: Case Reports Source Type: research