Human Psychopharmacology: Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

SSRI‐antipsychotic combination in psychotic depression: sertraline pharmacokinetics in the presence of olanzapine, a brief report from the STOP‐PD study
ConclusionSertraline pharmacokinetics were similar to historical descriptions in populations not taking antipsychotics. Unlike our unexpected finding that sertraline increases olanzapine apparent clearance, olanzapine exposure had no impact on sertraline pharmacokinetics. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Simon J. C. Davies, Benoit H. Mulsant, Alastair J. Flint, Barnett S. Meyers, Anthony J. Rothschild, Ellen M. Whyte, Margaret M. Kirshner, Denise Sorisio, Bruce G. Pollock, Robert R. Bies, Tags: Short Communication Source Type: research

Next‐day residual effects of gabapentin, diphenhydramine, and triazolam on simulated driving performance in healthy volunteers: a phase 3, randomized, double‐blind, placebo‐controlled, crossover trial
ConclusionsTogether, these data suggest that low‐dose gabapentin had no appreciable next‐day effects on simulated driving performance or cognitive functioning. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Gary G. Kay, Howard I. Schwartz, Mark A. Wingertzahn, Shyamalie Jayawardena, Russell P. Rosenberg Tags: Research Article Source Type: research

Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder
We examined the association of 5HTT gene methylation, which influences gene expression, and the 5HTTLPR genotype before antidepressant treatment and expression before and after treatment. The aims of this study were (1) to investigate the association between 5HTT methylation or expression in leukocytes and depression and (2) to investigate a possible effect of 5HTT methylation, expression, and genotype on clinical symptoms in MDD. The 5HTTLPR genotype was significantly associated with mean methylation levels in patients only (patients: r = 0.40, p = 0.035, controls: p = 0.96). The mean methylation level was sig...
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Jun‐ichi Iga, Shin‐ya Watanabe, Shusuke Numata, Hidehiro Umehara, Akira Nishi, Makoto Kinoshita, Masatoshi Inoshita, Shinji Shimodera, Hirokazu Fujita, Tetsuro Ohmori Tags: Research Article Source Type: research

Genetic association analysis of N‐methyl‐d‐aspartate receptor subunit gene GRIN2B and clinical response to clozapine
ConclusionsOur findings do not support a role for these GRIN2B variants in altering response to clozapine in our sample. Investigation of additional glutamate variants in clozapine response is warranted. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 15, 2016 Category: Psychiatry Authors: Danielle L. Taylor, Arun K. Tiwari, Jeffrey A. Lieberman, Steven G. Potkin, Herbert Y. Meltzer, Jo Knight, Gary Remington, Daniel J. Müller, James L. Kennedy Tags: Research Article Source Type: research

The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: a double‐blind and placebo‐controlled trial
ConclusionThese findings suggest the probable efficacy of pioglitazone as an augmentation therapy in reducing the negative symptoms of schizophrenia. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Negar Iranpour, Atefeh Zandifar, Mehdi Farokhnia, Amirhossein Goguol, Habibeh Yekehtaz, Mohammad‐Reza Khodaie‐Ardakani, Bahman Salehi, Sophia Esalatmanesh, Atefeh Zeionoddini, Payam Mohammadinejad, Arefeh Zeinoddini, Shahin Akhondzadeh Tags: Research Article Source Type: research

Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5
ConclusionsIndividual differences in metabolic clearance of risperidone under the present conditions were not significantly influenced by the genotypes of CYP2D6 or CYP3A5. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Maho Okubo, Shoko Morita, Norie Murayama, Youichi Akimoto, Akiko Goto, Hiroshi Yamazaki Tags: Research Article Source Type: research

Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non‐smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3
ConclusionsOlanzapine clearance was not affected by CYP2D6 or FMO3 genotypes or smoking behavior as a single factor under the present conditions because olanzapine clearance is mediated by multiple enzymes involved in two major and one minor pathways. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Maho Okubo, Momoko Narita, Norie Murayama, Youichi Akimoto, Akiko Goto, Hiroshi Yamazaki Tags: Research Article Source Type: research

Mixing alcohol with energy drink (AMED) and total alcohol consumption: a systematic review and meta‐analysis
In conclusion, between‐group comparisons suggest that heavy alcohol consumption is one of the several phenotypical differences between AMED and AO consumers. Within‐subject comparisons revealed, however, that AMED consumption does not increase the total amount of alcohol consumed on a single drinking episode. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 19, 2016 Category: Psychiatry Authors: Joris C. Verster, Sarah Benson, Sean J. Johnson, Andrew Scholey, Chris Alford Tags: Review Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 19, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Does elevated peripheral benzodiazepine receptor gene expression relate to cognitive deficits in methamphetamine dependence?
ConclusionThe results suggest that systemic inflammatory effects can be associated with chronic METH abuse, and this may relate to the cognitive deficits seen in METH dependence. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Siriluk Veerasakul, Samur Thanoi, Paritat Watiktinkorn, Gavin P. Reynolds, Sutisa Nudmamud‐Thanoi Tags: Short Communication Source Type: research

Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5‐HTTLPR‐S/Lg polymorphisms
ConclusionsThese preliminary data suggest that pharmacological mechanisms and genetics need to be considered in the development of neuroimaging markers for the evaluation of antidepressant treatments. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Rajamannar Ramasubbu, Ashley Burgess, Ismael Gaxiola‐Valdez, Filomeno Cortese, Darren Clark, Anne Kemp, Bradley Goodyear, Glenda Macqueen, N. Torben Bech‐Hansen, Jane Foster, Vaibhav A. Diwadkar Tags: Research Article Source Type: research

A randomized, double‐blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally
ConclusionsThe use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Todd M. Solomon, Jarrett Leech, Guy B. deBros, Cynthia A. Murphy, Andrew E. Budson, Elizabeth A. Vassey, Paul R. Solomon Tags: Research Article Source Type: research

Pharmacology for sleep disturbance in PTSD
Symptoms of sleep disturbance, particularly nightmares and insomnia, are a central feature of post‐traumatic stress disorder (PTSD). Emerging evidence suggests that specific treatment of PTSD‐related sleep disturbance improves other symptoms of the disorder, which in turn suggests that such disturbance may be fundamental to development and maintenance of the disorder. This mini‐review focuses on pharmacological treatment of sleep disturbance in adult PTSD (specifically, studies testing the efficacy of antidepressants, adrenergic inhibiting agents, antipsychotics and benzodiazepine and non‐benzodiazepine hypnotics)....
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Gosia Lipinska, David S. Baldwin, Kevin G. F. Thomas Tags: Short Communication Source Type: research

Effect of polymorphisms on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 6, 2015 Category: Psychiatry Tags: Erratum Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 6, 2015 Category: Psychiatry Tags: Issue Information Source Type: research