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Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder
ConclusionConcomitant use of aprepitant + paroxetine for 6 weeks did not provide greater antidepressant benefit compared with paroxetine + placebo in patients with major depression. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: William A. Ball, Duane B. Snavely, Richard J. Hargreaves, Armin Szegedi, Christopher Lines, Scott A. Reines Tags: Research Article Source Type: research

Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population
ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Yutaka Mizuki, Manabu Takaki, Yuko Okahisa, Shinji Sakamoto, Masafumi Kodama, Hiroshi Ujike, Yosuke Uchitomi Tags: Research Article Source Type: research

Arousal and the attentional network in panic disorder
Although a great deal of information about the neurobiology of panic disorder is now available, there is a need for an updated etiological model integrating recent findings on the neurobiology of the arousal system and its relationship with higher cortical functions in panic disorder. The current mini‐review presents psychophysiological, molecular biological/genetic and functional neuroimaging evidence for dysfunction in major arousal systems of the brain. Such dysfunction may influence the development of panic disorder by precipitating autonomic bodily symptoms and at the same time increasing vigilance to these sensatio...
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Maximilian J. Geiger, Susanne Neufang, Dan J. Stein, Katharina Domschke Tags: Short Communication Source Type: research

Use of antidepressant medication and suicidal ideation—the Northern Finland Birth Cohort 1966
ConclusionIn a large unselected cohort, antidepressant medication was not associated with increased suicidal ideation when other symptoms of depression and anxiety were taken into account. The assessment of insomnia might be useful for identifying individuals liable to have increased suicidal ideation while on antidepressant medication. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Ina Rissanen, Erika Jääskeläinen, Matti Isohanni, Hannu Koponen, Matti Joukamaa, Antti Alaräisänen, Jouko Miettunen Tags: Research Article Source Type: research

How well do clinicians and patients agree on depression treatment outcomes? Implications for personalized medicine
ConclusionThe levels of disagreement for response and remission were too high for CR and SR scales to be considered interchangeable for research on patient‐level outcomes. Anxiety does not meaningfully impact SR–CR agreement. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Boadie W. Dunlop, Bhrett McCabe, James M. Eudicone, John J. Sheehan, Ross A. Baker Tags: Research Article Source Type: research

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action
ConclusionsResearch conducted so far provides initial support for the use of saffron for the treatment of mild‐to‐moderate depression. Further research is required to expand our understanding of the role and actions of saffron in major depression. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Adrian L. Lopresti, Peter D. Drummond Tags: Review Article Source Type: research

Anticonvulsants to treat post‐traumatic stress disorder
ConclusionsFuture long‐term studies with larger sample sizes are needed to investigate the clinical utility of anticonvulsants for post‐traumatic stress disorder treatment. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 11, 2014 Category: Psychiatry Authors: Hee Ryung Wang, Young Sup Woo, Won‐Myong Bahk Tags: Review Article Source Type: research

The effect of desvenlafaxine 50 mg/day on a subpopulation of anxious/depressed patients: a pooled analysis of seven randomized, placebo‐controlled studies
ConclusionDesvenlafaxine 50 mg/day significantly improved depressive symptoms compared with placebo in major depressive disorder patients with clinically relevant anxiety symptoms. Improvement in the HAM‐D17 total score was similar for anxious/nonanxious groups. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 11, 2014 Category: Psychiatry Authors: Susan G. Kornstein, Christine J. Guico‐Pabia, Rana S. Fayyad Tags: Research Article Source Type: research

Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsMinocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 4, 2014 Category: Psychiatry Authors: Kazuto Oya, Taro Kishi, Nakao Iwata Tags: Research Article Source Type: research

A randomised, double‐blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin–noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine
ConclusionsVortioxetine was noninferior and significantly superior to agomelatine in major depressive disorder patients with previous inadequate response to a single course of SSRI/SNRI monotherapy. Vortioxetine was safe and well tolerated. © 2014 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 3, 2014 Category: Psychiatry Authors: Stuart A. Montgomery, Rebecca Z. Nielsen, Lis H. Poulsen, Lars Häggström Tags: Research Article Source Type: research

Modulation of auditory deviance detection by acute nicotine is baseline and deviant dependent in healthy nonsmokers: a mismatch negativity study
ConclusionsThese findings provide preliminary support for the role of nicotinic neurotransmission in sensory memory processing of auditory change and suggest that nicotinic receptor modulation can both enhance and diminish change detection, depending on baseline MMN and its eliciting stimulus feature. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 9, 2014 Category: Psychiatry Authors: Verner Knott, Danielle Impey, Tristan Philippe, Dylan Smith, Joelle Choueiry, Sara Salle, Heather Dort Tags: Research Article Source Type: research

The potential role of atypical antipsychotics in the treatment of panic disorder
ConclusionsAlthough the majority of the evidence regarding the efficacy of atypical antipsychotics in the treatment of panic disorder comes from small, open‐label studies, this review suggests the potential role of atypical antipsychotics in treating panic disorder. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 9, 2014 Category: Psychiatry Authors: Hee Ryung Wang, Young Sup Woo, Won‐Myong Bahk Tags: Review Article Source Type: research

Administration of exogenous melatonin increases spreading activation in lexical memory networks
ObjectiveSeveral studies have examined the effect of exogenous melatonin on memory and cognitive functioning. Many of these investigations have reported improvement in recall and recognition as well as performance on various other indices of neuropsychological functioning. However, there have been no investigations reported that have examined the effects of exogenous melatonin administration on spreading activation in lexical and semantic memory networks. Hence, the purpose of this investigation was to determine the effects of melatonin on spreading activation. MethodsParticipants were randomly assigned to either a 3‐mg ...
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Paul S. Foster, Ransom W. Campbell, Megan R. Williams, Kaylei K. Branch, Katelyn M. Roosa, Caitlin Orman, Valeria Drago Tags: Short Communication Source Type: research

Is environmental temperature related to renal symptoms, serum lithium levels, and other laboratory test results in current lithium users?
ConclusionsThe association of temperature with lithium levels, renal symptoms, and laboratory tests appears to be of relatively little clinical importance in lithium users in temperate climates. However, future research should re‐examine patients living in climates with extreme temperatures (e.g., >40°C), who may theoretically be at higher risk. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Soham Rej, Bandar AlAqeel, Marilyn Segal, Nancy C.P. Low, Istvan Mucsi, Christina Holcroft, Karl Looper Tags: Short Communication Source Type: research

Effects of alcohol and energy drink on mood and subjective intoxication: a double‐blind, placebo‐controlled, crossover study
ConclusionsThe co‐ingestion of an energy drink with alcohol does not differently influence blood alcohol content recordings or subjective intoxication compared with alcohol alone, although some mood items are differentially affected. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Sarah Benson, Andrew Scholey Tags: Research Article Source Type: research