Human Psychopharmacology: Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Haloperidol versus second‐generation antipsychotics in the long‐term treatment of schizophrenia
ConclusionsPatients treated with atypical antipsychotics appear to continue pharmacotherapy longer than patients treated with haloperidol. In addition, atypical antipsychotics seem to be more protective against recurrences than haloperidol. However, these results should be cautiously interpreted in the light of potential confounder factors such as duration of illness. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Massimiliano Buoli, René S. Kahn, Marta Serati, A. Carlo Altamura, Wiepke Cahn Tags: Research Article Source Type: research

International prescribing practices in obsessive–compulsive disorder (OCD)
ConclusionsPharmacotherapy for OCD varied significantly across sites. Prospective studies are required to determine the cultural, pharmacoeconomic and pharmacogenomic factors that may play a role in the variation in prescribing practices internationally and whether these variations influence treatment outcomes. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Vlasios Brakoulias, Vladan Starcevic, Amparo Belloch, Liliana Dell'Osso, Ygor A. Ferrão, Leonardo F. Fontenelle, Christine Lochner, Donatella Marazziti, Andrew Martin, Hisato Matsunaga, Euripedes C. Miguel, Y C Janardhan Reddy, Maria C. Rosário, Roseli Tags: Research Article Source Type: research

First‐generation antipsychotics and QTc: any role for mediating variables?
ConclusionsOur findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Giuseppe Carrà, Cristina Crocamo, Francesco Bartoli, Annamaria Lax, Martina Tremolada, Claudio Lucii, Giovanni Martinotti, Michela Nosè, Irene Bighelli, Giovanni Ostuzzi, Mariasole Castellazzi, Massimo Clerici, Corrado Barbui, Tags: Research Article Source Type: research

A simple method for optimising transformation of non‐parametric data: an illustration by reference to cortisol assays
Neuroendocrine data are typically positively skewed and rarely conform to the expectations of a Gaussian distribution. This can be a problem when attempting to analyse results within the framework of the general linear model, which relies on assumptions that residuals in the data are normally distributed. One frequently used method for handling violations of this assumption is to transform variables to bring residuals into closer alignment with assumptions (as residuals are not directly manipulated). This is often attempted through ad hoc traditional transformations such as square root, log and inverse. However, Box and Co...
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: James E. Clark, Jason W. Osborne, Peter Gallagher, Stuart Watson Tags: Research Article Source Type: research

Pharmacological treatment of acute agitation associated with psychotic and bipolar disorder: a systematic review and meta‐analysis
ConclusionBecause of limitations of available research, firm conclusions could not be drawn regarding the efficacy and safety of any identified intervention. Based on our results, there is no evidence that one drug is more effective or preferred over any other and treatment decisions could be made based on individual patient needs or costs. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Yenal Dundar, Janette Greenhalgh, Marty Richardson, Kerry Dwan Tags: Research Article Source Type: research

Suicide risk and antipsychotic side effects in schizophrenia: nested case –control study
ConclusionsA lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 24, 2016 Category: Psychiatry Authors: Johan Reutfors, Eric Clapham, Shahram Bahmanyar, Lena Brandt, Erik G. J önsson, Anders Ekbom, Robert Bodén, Urban Ösby Tags: Short Communication Source Type: research

The sleep effects of lurasidone: a placebo‐controlled cross‐over study using a 4‐h phase‐advance model of transient insomnia
ConclusionsLurasidone had a sleep maintenance effect without effects on sleep onset, rapid eye movement, or slow‐wave sleep. Lurasidone is likely to be beneficial to patients with disturbed sleep, particularly those with sleep maintenance problems. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 24, 2016 Category: Psychiatry Authors: Andrew D. Krystal, Gary Zammit Tags: Research Article Source Type: research

The effects of alcohol mixed with energy drink (AMED) on subjective intoxication and alertness: results from a double‐blind placebo‐controlled clinical trial
ConclusionMixing alcohol with energy drink had no overall masking effect on subjective intoxication caused by alcohol, nor had a relevant effect on subjective alertness‐sleepiness ratings. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 5, 2016 Category: Psychiatry Authors: Aurora J. A. E. Loo, Nienke Andel, Charlotte A. G. H. Gelder, Boris S. G. Janssen, Joep Titulaer, Jimmy Jansen, Joris C. Verster Tags: Research Article Source Type: research

Genetic mechanisms of electroconvulsive therapy response in depression
Electroconvulsive therapy (ECT) is known to be one of the most effective treatments for managing depression and other severe mental illnesses. Nevertheless, the exact mechanisms underlying response to ECT remain uncertain. This mini‐review presents clinical findings regarding the role of genetic factors in the aetiology of the ECT response. Studies on the role of variation in the catechol‐O‐methyltransferase (COMT) gene; other dopamine‐, serotonin‐, and G‐protein‐related genes; brain‐derived neurotrophic factor (BDNF); apolipoprotein E (APOE); angiotensin I‐converting enzyme (ACE) and vascular endothelial...
Source: Human Psychopharmacology: Clinical and Experimental - April 5, 2016 Category: Psychiatry Authors: Janine J. Benson‐Martin, Dan J. Stein, David S. Baldwin, Katharina Domschke Tags: Short Communication Source Type: research

Evaluation of interleukin‐6 and serotonin as biomarkers to predict response to fluoxetine
Conclusion5‐HT and IL‐6 may not serve as useful markers of response to fluoxetine because of inconsistent results across different studies. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 26, 2016 Category: Psychiatry Authors: Aarthi Manoharan, Ravi Philip Rajkumar, Deepak Gopal Shewade, Rajan Sundaram, Avin Muthuramalingam, Abialbon Paul Tags: Research Article Source Type: research

A simulated car‐driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers
ConclusionsLevocetirizine and fexofenadine did not impair psychomotor performance in subjects performing simulated car‐driving tasks, while diphenhydramine did impair psychomotor performance in the subjects. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 21, 2016 Category: Psychiatry Authors: Akie Inami, Rin Matsuda, Thomas Grobosch, Hiroshi Komamura, Kazuko Takeda, Yusuke Yamada, Masayasu Miyake, Kotaro Hiraoka, Marcus Maurer, Kazuhiko Yanai, Manabu Tashiro Tags: Research Article Source Type: research

Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs
ConclusionSchizophrenic patients showed earlier onset and longer DUI compared with patients with other SSDs. Data on the total sample showed a later age of onset and a reduced DUI across epochs. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 6, 2016 Category: Psychiatry Authors: Maria Carlotta Palazzo, Chiara Arici, Bernardo Dell'Osso, Laura Cremaschi, Benedetta Grancini, Giulia Camuri, Beatrice Benatti, Lucio Oldani, Cristina Dobrea, Alma Cattaneo, Alfredo Carlo Altamura Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 6, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Validation of the 17‐item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN‐AMPS) data
ConclusionsOur results support the consensus definition of response based on HDRS‐17 scores (>50% decrease from baseline). A similar definition of response may apply to the HDRS‐7 and Bech‐6. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2016 Category: Psychiatry Authors: William V. Bobo, Gabriela C. Angleró, Gregory Jenkins, Daniel K. Hall‐Flavin, Richard Weinshilboum, Joanna M. Biernacka Tags: Research Article Source Type: research

Suicide risk and antipsychotic side effects in schizophrenia: nested case–control study
ConclusionsA lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Johan Reutfors, Eric Clapham, Shahram Bahmanyar, Lena Brandt, Erik G. Jönsson, Anders Ekbom, Robert Bodén, Urban Ösby Tags: Short Communication Source Type: research