Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non‐smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

ConclusionsOlanzapine clearance was not affected by CYP2D6 or FMO3 genotypes or smoking behavior as a single factor under the present conditions because olanzapine clearance is mediated by multiple enzymes involved in two major and one minor pathways. Copyright © 2016 John Wiley & Sons, Ltd.

Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Maho Okubo, Momoko Narita, Norie Murayama, Youichi Akimoto, Akiko Goto, Hiroshi Yamazaki Tags: Research Article Source Type: research