Pilomatrix carcinoma of the head and neck: Case report and literature review.
We present the unique case of a 63-year-old man with a pilomatrix carcinoma of the left parotid region. He had bilateral cervical lymph node spread but no detectable distant metastasis. The patient underwent a wide excision of the lesion with a radical parotidectomy, temporal bone resection, bilateral neck dissections, and post-operative radiation.
The literature reports a poor prognosis associated with regional spread occurring with distant metastasis. The patient we report is alive at over two years post-operatively. With only one other case of a head and neck pilomatrix carcinoma ever reported in Canada, our report an...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Primary signet-ring squamous cell carcinoma of the oral cavity: The first intraoral case.
Conclusion: This finding together suggested squamous cell carcinoma originating from the excretory duct of the submandibular gland. This case illustrates a rare malignant neoplasm and the importance of oral examination, including palpation. This study reports the first case of signet-ring intraoral submucosal squamous cell carcinoma originating from the excretory duct of the submandibular gland. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Cisplatin can be safely used in head and neck cancer patients with history of renal transplantation: A case report and literature review.
We report a case of cisplatin usage concurrently with radiation in unresectable head and neck cancer (SCC), along with a review of the literature, demonstrating the safety of its use. A 52-year-old lady with unresectable T4N2cMx oropharyngeal SCC was on immunosuppression with tacrolimus x 6 years following a cadaveric kidney transplant. She was treated with definitive concurrent chemoradiation with cisplatin. She received prophylactic intravenous saline (IVF) three-times-a-week. She received 6 weekly doses of 40mg/m2 cisplatin (cumulative dose 240mg/m2) I.V concurrent with radiation, with no significant change in renal fun...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Increased in dose to organ at risks did not correlate with the weight loss but did correlate with the lateral neck dimension reduction and volume changes for head and neck patients treated with intensity-modulated radiotherapy.
Conclusion: This study shows the impact of weight loss largely affected the dose deposited to the critical organs when there is a great change in lateral separation and volume changes. Therefore, it is worthwhile to take additional measure in lateral neck separation as a guide in making re-planning decision. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Ezrin and podoplanin expressions are associated in invasion front of lip cancer.
Conclusion.The interpretation of our results reinforce that the tumor cells in the invasive front tumor expressed strongly both podoplanin (membranous and cytoplasmic) as cytoplasmic ezrin and it suggests a participation of these proteins in the process of invasion in lip cancer. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Valproic acid suppresses growth and enhances cisplatin cytotoxicity to larynx cancer cells.
Larynx cancer is the most common head and neck neoplasia in developed nations. The treatment of advanced larynx cancer include chemotherapy, often using cisplatin. The limitations of many antineoplastic drugs are their low delivery into respiratory tissues, thus the need of higher doses which results in severe side effects, and the development of drug resistance by cancer cells. Therefore the need of drugs and drug combinations that potentiates each other, increasing safety by reducing doses and act on several pathways at the same time, acting more specifically on cancer cells.
Histone deacetylase inhibitors are a promis...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Multiple extramedullary plasmacytoma involving the vallecula: A case report with 3-year follow-up.
Discussion: It is difficult to associate multifocal polyps or nodules in the upper airway with EMPs because EMPs have no specific macroscopic appearance or symptom profile. The present case of multifocal EMPs at the larynx and oropharynx is novel, and this is the first case report on vallecular EMP in the related English-language literature. Moreover, this is the first case of multiple EMP that did not progress to multiple myeloma within a 3-year follow-up without adjuvant radiotherapy. Therefore, this case calls into question the need for adjuvant radiotherapy in cases of EMPs if complete excision with negative margins ha...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Reporting of a primary sinonasal neuroendocrine small cell carcinoma in the paediatric age group.
Conclusion- SCCNETs have an unfavorable outcome. Further improvements in our understanding of the pathology and treatment strategies are needed to combat the disease. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Iatrogenic Horners syndrome with abducent nerve paralysis after cervical schwannoma excision.
Horner’s syndrome usually occurs after surgical intervention around carotid artery. A complete intracranial course of abducent nerve prevents its injury during neck surgery. We encountered an unusual complication in a 31-year-old female who underwent schwannoma excision under general anaesthesia. Patient developed Horner’s syndrome and lateral rectus palsy in immediate post-operative period. Post-operative investigations did not reveal any abnormality in abducent nerve. Patient was managed conservatively and improved. We believe that either both neural injuries occurred independently or cautery may have caused ...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Head and Neck Oncology - the sixth year (part1): Editorial.
No abstract available for this type of article. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Radiotherapy induced hearing loss in head neck cancers: Screening with DPOAE.
Conclusion: OAE is simple, objective and cost effective tool that doesn’t require infrastructure and special training. Although high frequency audiometry is a preferred tool but OAE can be equally used to observe the RT induced hearing loss. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Cholesterol granuloma: An uncommon clinical entity of the maxillary sinus.
This article reports a case of a 30 year-old man, with complaints of postnasal discharge, cough and itching in bilateral ears. CT imaging showed polypoidal mass in left maxillary sinus. Endoscopic sinus surgery was performed, the cholesterol granuloma was removed from left maxillary sinus and tissue was submitted in our department for histopathological examination. It microscopically showed foreign body giant cell reaction to cholesterol crystals. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Primary sclerosing mucoepidermoid carcinoma of the thyroid: A case report and review of the literature.
Conclusion: Although SMECE is considered to be a relatively slow growing and non-aggressive tumor, occasional metastasis do occur. Physicians should be aware of extended operation, include total thyroidectomy and/or neck node dissection for metastatic lesion of neck node. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Synchronous bilateral tongue cancer treated with chemoradiotherapy using superselective intra-arterial infusion via bilateral superficial temporal arteries: a case report.
We report a case of synchronous bilateral tongue cancer involving a 57-year-old man. The patient was referred to our hospital in 2006 and was pathologically diagnosed with bilateral tongue squamous cell carcinoma. Two catheters were superselectively inserted into the bilateral lingual arteries via the bilateral superficial temporal arteries. Radiotherapy combined with superselective intra-arterial chemotherapy using cisplatin and docetaxel was performed. The total dose of cisplatin was 258 mg/body, and that of docetaxel was 154.8 mg/body. Radiotherapy was performed at 2 Gy/fraction/day, and the total dose delivered to the ...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Primary non-Hodgkins B cell lymphoma of the thyroid gland: A rare entity.
The clinical and pathologic spectrum of lymphoproliferative disorders affecting the thyroid gland is diverse. The aim of the article is to present a case of primary malignant lymphoma of thyroid, which is relatively uncommon representing less than 5% of all thyroid malignancies. The majority of thyroid lymphomas are diffuse large cell of B-cell origin. A 65 year female presented with diffuse enlargement of thyroid gland since 20 days. There was no pain or difficulty in swallowing. Cytological findings were suggestive of malignant round cell tumor with closest resemblance to non- Hodgkins lymphoma. On trucut biopsy, t...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
