Radiation-induced high grade spindle cell sarcoma of the sternomastoid muscle: case report.
Sarcomas developing as primary malignancies of the head and neck are a rare complication after radiation therapy. This kind of sarcoma has variable clinicopathological appearances and behaviour. Radiation-induced spindle cell rhabdomyosarcoma (RMS)of the sternomastoid muscle is a very rare sarcoma and has very seldom been described in the literature.
Herein we report the development of a rapidly growing mass over the lateral side of the neck appearing after 7 yearsin a patient with a history of laryngeal carcinoma who received radiotherapy. The process of diagnosis and management using combined surgery and targe...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
English law for the surgeon III: Loss of Chance: Gregg v Scott revisited.
Traditionally, in the United Kingdom and Europe, the surgeon was generally not troubled by litigation from patients presenting as elective as well as emergency cases, but this aspect of custom has changed. Litigation by patients now significantly affects surgical practice and vicarious liability often affects hospitals. We discuss some fundamental legal definitions, a must to know for a surgeon, and highlight some interesting cases.
(Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Li C, Liu Y, Liu J, Chen Y, Li Z, Chen X, Yang K, Li M, Liu Z. Rapamycin inhibits human glioma cell proliferation through downregulating mTOR pathway and upregulating microRNA-143. Head Neck Oncol. 2012 Oct 14;4(3):66.
The objective of this study was to test the hypothesis that rapamycin regulates cell proliferation, apoptosis, and glycolysis in human glioma cells and investigate the underlying mechanism.Human malignant glioma cell line U251 cells were treated with 100mM rapamycin for 6, 12, or 24 hours. Cell proliferation and apoptosis were assayed by MTT and flow cytometric analyses. RNA and protein expression levels were then measured by real-time PCR (RT-PCR) and western blotting, respectively. The administration of rapamycin inhibited the proliferation and induced the apoptosis of U251 cells. With prolonged treatment with rapamycin,...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Ren J, Sun Y, Zhao X, Wang X, Feng J, Liu M, Zhu D. Downregulation of miR-21 regulates MMP-2 expression and suppress migration of Laryngeal squamous cell carcinoma. Head Neck Oncol. 2012 Sep 9;4(2):65.
In this study, we measured cell migration and nude mice tumorigenicity assays in ASO-mir-21 transfected Hep-2 cells. We also employed western blot and immunohistochemistry to detect the MMP-2 expression in LSCC after miR-21 transfection. Our data showed that the migration ability of Hep-2 cells transfected with ASO-miR-21 was significantly decreased compared with the control. Downregulation of miR-21 dramatically suppressed the tumorigenicity of Hep-2 cells in nude mice. Furthermore, ASO-mir-21 could inhibit the expression of MMP-2 compared with the control both in vitro and in vivo. Our findings suggest that miR-21 is inv...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Yokoyama J, Ohba S, Ito S, Fujimaki M, Shimoji K, Kojima M, Ikeda K. Impact of lymphatic chemotherapy targeting metastatic lymph nodes in patients with tongue cancer (T3, N2b, M0) using intra-arterial chemotherapy. Head Neck Oncol. 2012 Sep 9;4(2):64.
Conclusion
The CDDPconcentrations in metastatic nodeswere significantly higher than in non-SLNs.This novel drug delivery system is feasible for lymphatic chemotherapy targeting metastatic nodes in patients with T3N2bM0 tongue cancer. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Yoshii R, Yokoyama J, Ohba S, Fujimaki M, Anzai T, Ito S, Ikeda K. Impact of endoscopic surgery for an uncommon liposarcoma of the posterior wall of oropharynx: A case report. Head Neck Oncol. 2012 Sep 9;4(2):63.
Conclusion
An uncommon liposarcoma from oropharynx extending to hypopharynx was safely resected transorally with an endoscope, preserving good postoperative function and appearance. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Kafas P, Parisis N, Tziafas D, Kalfas S, Upile T, Jerjes W. Correlation between bcl-2 and ki67 in radicular epitheliated granulomas. Head Neck Oncol. 2012 Sep 9;4(2):62.
Conclusions
The correlation of the oncoproteins bcl2 and ki67 may be characterized by their synchronous presence. Mainly the basal layer expressed this characteristic indicating its importance in the regulation of epithelial apoptosis. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Chen SW, Zhang Q, Yang AK, Li Z, Zhong Y, Li H, Zeng Y, Zhuang SM, Wang LP, Song LB, Guo ZM, Song M. Overexpression and cytoplasmic localization of Sam68 correlate with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer. Head Neck Oncol. 2012 Sep 9;4(2):61.
In this study, we report Sam68 overexpression in human clinically N0 (cN0) oral tongue cancer and its correlation with clinicopathologic characteristics and prognosis of patients. Analysis of oral tongue cancer cell lines and cancerous tissues revealed that Sam68 was up-regulated at both the mRNA and protein levels. Immunohistochemical study of Sam68 protein expression and localization in 181 cN0 oral tongue cancer samples confirmed the results, which showed significantly shorter overall and disease-free survival after surgery in cases with higher Sam68 expression (P = 0.009 and 0.002, respectively) and cytoplasmic localiz...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Yokoyama J, Ohba S, Ito S, Fujimaki M, Yoshimoto H, Hanaguri M, Ikeda K. A feasibility study of lymphatic chemotherapy targeting sentinel lymph nodes of patients with tongue cancer (T3,N0,M0) using intra-arterial chemotherapy. Head Neck Oncol. 2012 Sep 9;4(2):60.
Conclusion
The THP-ADM concentrations in SLNs were significantly higher than in non-SNLs. This novel drug delivery system is feasible for lymphatic chemotherapy targeting SLNs in patients with cT3N0M0 oral cancer. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Passier L, Doherty D, Smith J, McPhail S. Vestibular rehabilitation following removal of acoustic neuroma: a systematic review of randomised trials. Head Neck Oncol. 2012 Sep 9;4(2):59.
Conclusion
There is some evidence to support use of adaptation exercises for this clinical group. Clinical trial evidence does not support the use of habituation exercises alone, although when combined with adaptation exercises and balance and gait training, habituation exercises may have some benefit. Further research is required to determine the optimal combination of vestibular rehabilitation interventions, as well as volume and timing of interventions. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Yokoyama J, Ito S, Ohba S, Fujimaki M, Ikeda K, Hanaguri M. A safe and cosmetic method of removing the sternum by bone forceps for mediastinal dissection of recurrent thyroid cancer. Head Neck Oncol. 2012 Sep 9;4(2):58.
Conclusion
This novel method of removing the sternum by bone forceps is more effective than the conventional method for mediastinal dissection of recurrent thyroid cancer in terms of safety, aesthetic outcome and duration of hospitalization. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Anzai T, Yokoyama J, Ohba S, Ito S, Fujimaki M, Kojima M, Ikeda K. A case of severe hungry bone syndrome following parathyroidectomy analyzed with attention to alpha-klotho calcium regulator. Head Neck Oncol. 2012 Sep 9;4(2):57.
Conclusion
It’s imperative to carefully check serum calcium and symptoms following the parathyroidectomy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Anzai T, Yokoyama J, Ohba S, Ito S, Fujimaki M, Kojima M, Ikeda K. An important initial diagnosis of a patient with Graves' disease associated with myasthenia gravis, thyroid carcinoma, and thymoma. Head Neck Oncol. 2012 Sep 9;4(2):56.
Conclusion
If a patient is diagnosed with Graves’ disease, it is important to check for thyroid carcinoma, mediastinal disease and other autoimmune diseases at the same time. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Du C, Yang P, Zhang G, Hong C, Chen J, Dong X. Effect of Arsenic trioxide on EBV LMP1 mediated E-cadherin silencing in nasopharyngeal carcinoma. Head Neck Oncol. 2012 Sep 9;4(2):55.
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates cellular DNA methyltransferases, which results in hypermethylation and thus silencing of E-cadherin. We previously demonstrated that As2O3 can reduce LMP1 expression in human nasopharyngeal carcinoma (NPC) cells in vitro. The purpose of the current study is to determine whether As2O3 can rescue the expression of E-cadherin in NPC cells through repressing LMP1. The stable LMP1 (HNE1-LMP1) and its parental (HNE1) cell lines were treated with various concentration of As2O3for 48 h. The DNA methylation at E-cadheringene promoter of survival cells were investig...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Wang ZL, Tang ZC, Zhang Y, Zhang W, Yao J, Wei ZC, Zhang W, Qi B, Song XM, Wu YN. Neuropilin-1 down-regulation impairs cell migration and induces the differentiation of human tongue squamous cell carcinoma cells. Head Neck Oncol. 2012 Sep 9;4(2):54.
Conclusions
NRP-1 knockdown may inhibit the migration and invasion of tongue SCC by inducing a more differentiated cancer state. Considering the high NRP-1 expression in tongue squamous cell carcinoma, it may serve as a useful marker for differentiation and a target for tongue cancer treatment. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
