Wang ZL, Tang ZC, Zhang Y, Zhang W, Yao J, Wei ZC, Zhang W, Qi B, Song XM, Wu YN. Neuropilin-1 down-regulation impairs cell migration and induces the differentiation of human tongue squamous cell carcinoma cells. Head Neck Oncol. 2012 Sep 9;4(2):54.

Conclusions NRP-1 knockdown may inhibit the migration and invasion of tongue SCC by inducing a more differentiated cancer state. Considering the high NRP-1 expression in tongue squamous cell carcinoma, it may serve as a useful marker for differentiation and a target for tongue cancer treatment.
Source: Head and Neck Oncology - Category: Cancer & Oncology Source Type: research