Immune cell infiltration patterns and survival in head and neck squamous cell carcinoma.
Conclusions
These data demonstrate significant differences in the immune cell profile of HPV[+] and HPV[–] HNSCC. This study identifies several possible targets for immunotherapy and possible prognostic markers (FoxP3 and HLA-G) that may be specific to HNSCC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Joint effects of differentiation factor 15 and substance use of alcohol, betel quid and cigarette on risk of head and neck cancer.
Growth differentiation factor 15 (GDF15) is susceptible to areca nut exposure in oral cells and contributes to the progression of oral tumours. Here, we determined whether independent and combined effects between GDF15 and substance use of alcohol, betel quid and cigarette (ABC) influence the incidence of squamous cell carcinoma of the head and neck (SCCHN).
Serum level and genetic variants of GDF15 and substance use habits were evaluated in the risk of SCCHN using a case-control study with 1191 hospital-based volunteers.
Serum GDF15 level showed an increasing trend among controls and SCCHN patients with diffe...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Investigating the role of human papillomavirus in squamous cell carcinoma of the temporal bone.
Squamous cell carcinoma of the temporal bone is an uncommon tumour normally preceded by a history of inflammation within the external auditory canal or middle ear cavity. Although the human papillomavirus has been implicated in many head and neck malignancies, its role in the pathogenesis of carcinoma affecting the temporal bone has yet to be determined.
Polymerase chain reaction was used to detect high risk human papillomavirus subtypes. RNA in situ hybridization, DNA sequence analysis, and p16 immunohistochemistry were employed to confirm positive samples. All specimens underwent separate investigations for the presenc...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment.
NasopharyngealCarcinoma (NPC) relapse after primary treatment is a major cause of cancer-related death. There is little comprehensive information on long-termoutcomes particularly pertaining to the site of relapse.Therefore, the aim of this study was to determine the clinicopathologic features of NPCrelapse after primary treatment from 1425 patients referred to our institution from 2000 until 2006. After initial treatment, patients were reviewed at 3-6 month intervals. Information was collected on demographics, pre- and post-management and patient outcomes. The median age was 48 years(range 3-77 years) with complete data f...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Clinical and biological behaviour of vestibular Schwannomas: Signaling cascades involved in vestibular schwannoma resemble molecular and cellular mechanisms of injury induced Schwann cell de-differentiation.
Vestibular Schwannoma (VS) is a slow-growing, intracranial extra-axial benign tumor that develops from the vestibular nerve, or very rarely from the cochlear nerve. The tumor is located along the course of the nerve that is, between the inner ear and the brainstem in the internal auditory canal and the cerebello-pontine angle (CPA). This review summarizes the current knowledge on clinical and molecular aspects of vestibular schwannoma development with special emphasis on cellular de-differentiation of Schwann cells into plastic neural crest stem cell-like phenotype as the potentially involved cellular and molecular mechani...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The Reconstruction of head and neck defects with the submental island flap.
Conclusions－The submental island flap is a reliable alternative for head and neck defects reconstruction in cancer patients. For colossal defects in mouth floor, the submental island flap should involve with the submandibular gland, anterior belly of digastric muscle and mylohyoid muscle. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
A radiological and radiotherapeutic approaching of pediatric tumors in head and neck area.
The most common pediatric malignancies in head and neck area consisted of lymphoma, leukemia, brain tumors, neuroblastoma, Wilms’ tumor, sarcomas and primarily rhabdomyosarcoma. This review reports in brief radiological diagnosis and staging together with radiation treatment, in terms of common clinical practice.
Ultrasound, computerized tomography, Magnetic resonance Imaging and lately Positron Emission Tomography are playing an important diagnostic role, which is discussed. Further, the radiation treatment represents also an important weapon against pediatric neoplasia. In general the prescribed dose is 35 (1.7Gy...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Patient characteristics as indicators for poor quality of life after radiotherapy in advanced nasopharyngeal cancer.
Conclusions:Patients who experienced poor QOLafter radiotherapy tended to be female, to experience anxiety before treatment, and to lack a positive coping mode. Their QOL may be improved by timely identifying and offering them the proper intervention. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The recurrence of a soft palate teratoma in a neonate: a case report.
Teratomas are rare malformation containing cells from ectodermal, mesodermal and endodermal layers, seldom seen in the soft palate. A 2-day-old girl of a teratoma arising from the soft palate was treated with surgery. Unfortunately we found the recurrence in follow-up. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis.
Conclusion
In view of the property that aberrant DNA methylation occurs in the early developmental stages of LSCC, methylation markers aregood for the detection of visually undetectable cases in the LSCCtissues. However, based on the current markers panel, the accuracy of methylated DNA markers are not satisfactory for clinical use. Identification of novel methylated markers with higher sensitivity and specificity is warranted. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy.
Hidradenocarcinoma, the malignant counterpart of hidradenoma, is an extremely rare malignant tumour which may exhibit an aggressive clinical course.The standard primary treatment is wide local excision with or without lymph node dissection. Radiotherapy has also been used in some cases but with controversial outcomes. At the University of Thessaly – Faculty of Medicine and the University Hospital of Larissa, Greece, we successfully treated a hidradenocarcinoma of the skin of the temporo-parietal area, using a combination of electrochemotherapy and radiotherapy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Chondrosarcoma of the petrous bone: A challenging clinical entity.
Skull base chondrosarcomas are challenging lesions to treat for neurosurgeons. In the presented article we give a brief overview about this clinical entity. Furthermore we present an illustrated case with chondrosarcoma of the petrous bone and highlight microsurgical treatment options. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Efficacy and toxicity of radiotherapy for Graves ophthalmopathy: the University of Athens experience.
Conclusion:Orbital radiotherapy for Graves’ disease is a well-established treatment option, even if patients have failed previously with other treatment modalities such as corticosteroids and surgical decompression. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Mandibular lingual release approach: an appropriate approach for total or subtotal glossectomy.
Conclusion:MLRA offers improved space and exposure for removing primary tumor, avoids facial scarring and mandibulotomy and enables good chewing and swallowing function. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The intercondyle distance before and after resection of the mandible.
Conclusion
Reconstruction plates and bony reconstructions do not significantly change the intercondyle distance. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
