Monaghan MT, Bonner JA, Schaner PE, Caudell JJ. Dosimetric impact of target definitions on normal structures in head and neck cancer. Head Neck Oncol. 2011 Aug 11;3:34.
Conclusions
Smaller target volumes with the addition of an intermediate dose volume results in improved sparing of most normal tissues. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Mehrotra R, Gupta DK. Exciting new advances in oral cancer diagnosis: avenues to early detection. Head Neck Oncol. 2011 Jul 28;3:33.
The prognosis for patients with oral squamous cell carcinoma remains poor in spite of advances in therapy of many other malignancies. Early diagnosis and treatment remains the key to improved patient survival. Because the scalpel biopsy for diagnosis is invasive and has potential morbidity, it is reserved for evaluating highly suspicious lesions and not for the majority of oral lesions which are clinically not suspicious. Furthermore, scalpel biopsy has significant interobserver and intraobserver variability in the histologic diagnosis of dysplasia. There is an urgent need to devise critical diagnostic tools for early dete...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Likhacheva A, Rosenthal DI, Hanna E, Kupferman M, Demonte F, El-Naggar AK. Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome. Head Neck Oncol. 2011 Jul 27;3:32.
Conclusion
Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Pederson AW, Salama JK, Haraf DJ, Witt ME, Stenson KM, Portugal L, Seiwert T, Villaflor VM, Cohen EE, Vokes EE, Blair EA. Adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies. Head Neck Oncol. 2011 Jul 26;3:31.
Conclusions
Surgical resection followed by adjuvant chemoradiotherapy results in promising locoregional control for high-risk salivary malignancy patients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Dechaphunkul T, Pruegsanusak K, Sangthawan D, Sunpaweravong P. Concurrent chemoradiotherapy with carboplatin followed by carboplatin and 5-fluorouracil in locally advanced nasopharyngeal carcinoma. Head Neck Oncol. 2011 Jun 5;3:30.
Conclusions
Concurrent chemoradiotherapy with carboplatin followed by carboplatin and 5- fluorouracil could be considered as an alternative regimen for locally advanced nasopharyngeal carcinoma patients pertaining to a good overall response rate, 3-year overall survival and progression-free survival rate with good tolerability. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Bohannon IA, Carroll WR, Magnuson JS, Rosenthal EL. Closure of post-laryngectomy pharyngocutaneous fistulae. Head Neck Oncol. 2011 May 26;3:29.
Conclusions
Delayed secondary repair of pharygocutaneous fistulas after salvage laryngectomy is associated with a higher complication rate and poor success rates compared to use of vascularized tissue at the time of salvage laryngectomy. Prolonged wound healing in these patients is associated with hypothyroidism. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Eckardt AM, Kokemüller H, Tavassol F, Gellrich NC. Reconstruction of oral mucosal defects using the nasolabial flap: clinical experience with 22 patients. Head Neck Oncol. 2011 May 23;3:28.
Conclusions
The nasolabial flap is a valuable alternative for reconstruction of smaller defects of the oral cavity in particular in older and medically compromised patients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Kokemueller H, Rana M, Rublack J, Eckardt A, Tavassol F, Schumann P, Lindhorst D, Ruecker M, Gellrich NC. The Hannover experience: surgical treatment of tongue cancer--a clinical retrospective evaluation over a 30 years period. Head Neck Oncol. 2011 May 21;3:27.
Conclusions
We recommend categorical bilateral neck dissection in order to reliably remove occult lymph node metastases. Adjuvant treatment modalities should be applied more frequently in controlled clinical trials and should generally be implemented in cases with unclear margins and lymphatic spread.
Clinical relevance
This study provides new treatment strategies for primary tumour disease and for tumour recurrence. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Gomez-Rivera F, El-Naggar AK, Guha-Thakurta N, Kupferman ME. Rheumatoid arthritis mimicking metastatic squamous cell carcinoma. Head Neck Oncol. 2011 May 14;3:26.
We report a case of a cervical rheumatoid nodule in close relation to the hyoid bone mimicking a metastatic carcinoma. A 74-year-old female with a 15-year history of rheumatoid arthritis (RA) on treatment with methotrexate presented with tenderness of the right base of tongue. Imaging demonstrated a 1.4 cm cystic lesion at the hyoid bone. Biopsies were unsuccessful and the patient required surgical resection of the mass. A trans-cervical approach was used. Pathology revealed a necrotizing granuloma compatible with rheumatoid etiology. The clinician should be aware that, in a patient with a neck mass, in the presence of act...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Schwager K, Villa A, Rösli C, Neri D, Rösli-Khabas M, Moser G. A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head Neck Oncol. 2011 May 8;3:25.
Conclusions
These results suggests that an individualized treatment procedure (e.g., choice of L19, F8 or F16 based on immuno-PET or immunofluorescence procedure) may represent the most logical avenue for offering the best possible antibody to any given patient. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Upile T, Stimpson P, Christie M, Mahil J, Tailor H, Jerjes WK. Use of gel caps to aid endoscopic insertion of nasogastric feeding tubes: a comparative audit. Head Neck Oncol. 2011 May 7;3:24.
Discussion
We found the methodology to be of no greater benefit to our patients when compared to our alternative current practice for failed blind nasogastric tube insertion. We retain this methodology in our armamentarium for difficult circumstances but have continued with our standard practice for most patients needing nasogastric tube placement. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Rana M, Warraich R, Kokemüller H, Lemound J, Essig H, Tavassol F, Eckardt A, Gellrich NC. Reconstruction of mandibular defects - clinical retrospective research over a 10-year period -. Head Neck Oncol. 2011 Apr 28;3:23.
Conclusion
Based on this study, autogenous bone grafts are a reliable treatment modality for the reconstruction of mandibular bone defects with predictable aesthetic and functional outcomes. As the free vascularized fibular flap has the least resorption and failure rate, it should be the first choice for most cases of mandiblular reconstruction. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Liao YM, Kim C, Yen Y. Mammalian target of rapamycin and head and neck squamous cell carcinoma. Head Neck Oncol. 2011 Apr 24;3:22.
Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis and angiogenesis that impact local recurrence and survival. mTOR can also act as a biomarker for personalized adjuvant therapy. In in vivo and in vitro studies, mTOR inhibitor suppresses tumor growth and sensitizes HNSCC to radiation, cytotoxic agents and epidermoid growth factor receptor inhibitors. We have reviewed the pathogenesis of HNSCC, mTOR pathway, mTOR inhibitor and the role o...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Moser S, Beer M, Damerau G, Lübbers HT, Grätz KW, Kruse AL. A case report of metastasis of malignant mesothelioma to the oral gingiva. Head Neck Oncol. 2011 Apr 22;3:21.
Conclusion
This article highlights the importance of biopsy and histopathological diagnosis of oral lesions especially in case of a malignant history. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Peltonen JK, Vähäkangas KH, Helppi HM, Bloigu R, Pääkkö P, Turpeenniemi-Hujanen T. Specific TP53 mutations predict aggressive phenotype in head and neck squamous cell carcinoma: a retrospective archival study. Head Neck Oncol. 2011 Apr 22;3:20.
Conclusions
These data indicate that a TP53 mutation in L2, L3 or LSH is worth pursuing as a marker for predicting prognosis and response to radiation among HNSCC patients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
