The effect of intensity-modulated radiotherapy versus conventional radiotherapy on quality of life in patients with nasopharyngeal cancer: a cross-sectional study.
Conclusions: IMRT substantially improved QoL in NPC patients when compared to conventional radiotherapy, and the superiority become significant with prolonged follow-up time. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Integrin αvβ6 as a novel marker for diagnosis and metastatic potential of thyroid carcinoma.
In conclusion, the detection of αvβ6 expression may help to improve diagnostic accuracy and predict metastatic potential for thyroid carcinomas. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
ARID1A is a tumor suppressor and inhibits glioma cell proliferation via the PI3K pathway.
This study aims to identify a possible biomarker that could be used in the diagnosis and tumor grade assessment of gliomas. Additionally, the biological role of ARID1A was further characterized in glioma cells. Data was collected from sporadic gliomas specimens (n = 55) and normal brain tissues (n = 5), and ARID1A expression was examined by quantitative RT PCR and western blot. We verified the differential expression of ARID1A and evaluated the associations of ARID1A expression with the pathologic characteristics of gliomas. An ARID1A overexpression plasmid was constructed and transfected into the human glioblastoma cell l...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Surgical outcome of Carotid body tumor resection after percutaneous embolisation with ethylene-vinyl alcohol copolymer (Onyx®).
Conclusion: Preoperative embolization reduces intraoperative blood loss, improves operative field visualisation and consecutively diminishes damage to nerval and vascular structures. Percutaneous embolization via direct intratumoral puncture appears to achieve a higher degree of devascularization by affecting arterial vessels, capillary bed and venous drainage. Existing data suggest a decrease in intraoperative blood loss and fluoroscopy times over transarterial embolization. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Identification of high-risk human papillomaviruse (HPV-16 & 18) infection by multiplex PCR (MPX-PCR) and its expression in oral sub mucous fibrosis and oral squamous cell carcinoma.
This study concluded that multiplex
PCR (MPX-PCR) could be helpful for quick screening of HR-HPVs and it is highly convenient, simple and cost-effective tool for large scale multi-institutional study for developing countries. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
High HIF-1α expression genotypes increase odds ratio of oral cancer.
Conclusions: In conclusion, our study demonstrated that the T and A alleles of C1772T and G1790A polymorphisms of the HIF-1α gene increased the risk of ED and OSCC. C1772T and G1790A polymorphisms of the HIF-1α gene had differing patterns of allelic imbalance in the precancerous lesions and subsequent carcinoma, suggesting a complex genetic pattern of progression from dysplasia to carcinoma. These findings suggest an additional role for HIF-1α in OSCC development. Further studies are necessary to elucidate the HIF-1α pathway in carcinogenesis, which would facilitate the development of novel therapeu...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Impact of acute radiation induced toxicity of glutamine administration in several hypofractionated irradiation schedules for head and neck carcinoma.
Conclusion: In elderly patients suffered from SCCHN with comorbitities and unfit for daily irradiation and chemotherapy, it is possible an alternative schedule of hypofractionation when combined with the administration of GLN. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
A Novel application of a polyglycolic acid sheet in treating oral and oropharyngeal cancer.
The objective of the current study is to determine whether the use of a PGA sheet reduces postoperative complications in transoral surgery for oral and oropharyngeal cancer. We reviewed a series of 38 oral and oropharyngeal cancer patients who underwent transoral surgery. We evaluated the outcomes of PGA application and compared them to those of patients who received surgery prior to the introduction of this technique. In all patients, the postoperative clinical course was without significantcomplications. Patients with oropharyngeal cancer in whom the PGA sheet was used showed significantly lower incidence of pain followi...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Bilateral para-tracheal lignocaine infiltration in open surgical tracheostomy.
Discussion and conclusion:Lignocaine infiltration in para-tracheal space just before tracheotomy lead to absent cough reflex with no exacerbation in respiratory distress. We strongly advocate use of lignocaine in para-tracheal space just before tracheotomy in open surgical tracheostomy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Chemotherapy plus radiotherapy makes curability a possibility in nasopharyngeal carcinoma patients with distant metastasis at diagnosis.
Conclusions: Adding radiotherapy to 4-6 cycles of paclitaxel-based chemotherapy significantly improved PFS and OS in distant metastaticNPC patients. Chemotherapy+radiotherapy make curability a possibility in thesepatients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Lymph node ratio and capsule penetration as independent risk factors in head and neck squamous cell carcinoma.
Conclusions: Lymph node ratio is an independent predictor of survival and should be examined in every patient undergoing neck dissection. Capsule penetration of lymph nodes was another independent prognostic factor. In cases of capsule penetration or inappropriate lymph node ratio, adjuvant therapies are necessary. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Efficacy, cosmesis and skin toxicity in a hypofractionated irradiation schedule for cutaneous basal cell carcinoma of the head and neck area.
CONCLUSION:Our irradiation schedule achieves very high local control rate with very good cosmetic and functional results, and could be an alternative radiotherapy treatment for elderly patients with BCC of the head and neck area. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
A novel platform for nucleic acid biomarker-based diagnosis of thyroid cancer.
The standard of care for patients with clinically significant thyroid nodules is an ultrasound-guided fine needle aspiration biopsy with cytologic evaluation. Nearly 20% of patients are found to have indeterminate cytology, requiring surgical thyroidectomy to exclude malignancy; nucleic acid-based biomarkers to improve diagnosis are promising, but there is clearly a need for improved technology to bring these into common clinical practice. Here we demonstrate the use of a thermoplastic disposable microfluidic chip to extract nucleic acids from thyroid cancer cell lines and thyroid tissue for potential use as a ...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Anaplastic large cell anaplastic lymphoma kinase + non-Hodgkin lymphoma in a 10-year-old male discovered during dental visit: a case report.
Non-Hodgkin lymphoma (NHL) is rare in children, even if they are the third most frequent tumor. Management of a NHL child is complex and coordinate presence of haematologists, surgeons, radiotherapist, neurologists, psychologists and others expert personnel is required.
Our patient presented with a bulky mass, approximately 5 cm in diameter, which grew from his upper left maxilla bone, causing gum bulge, and thus left side of his face from lip to eye appeared swollen. A total body TC-PET exam revealed that the mass was growing in the mouth and in the maxillary bone, and that there were many bulky nodes both in t...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Reconstruction of nasal ala with nasolabial perforator flap after cancer removal.
Before the concept of perforator anatomy and perforasome has been established, coverage of defects in nasal alar was performed with random local flaps from adjacent skin. This method was fairly successful, but restrictions in flap mobility were a major drawback. Attempting to overcome this disadvantage, authors have found considerable advantage in flap mobility and rotation by using perforator flaps based on nasolabial perforators. After removal of malignancy on nose, eight patients had received reconstruction with perforator flap based on nasolabial perforator of facial artery, which was elevated as an island pattern. All...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
