Gcn4p and the Crabtree effect of yeast: Drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade‐offs of adaptation to galactose through systems biology
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - March 1, 2014 Category: Research Authors: José L. Martínez, Sergio Bordel, KuFk‐Ki Hong, Jens Nielsen Tags: Research Paper Source Type: research
Inhibitory effect of verapamil on Candida albicans hyphal development, adhesion and gastrointestinal colonization
This study investigated the in vitro and in vivo effect of verapamil, a calcium channel blocker, on these processes. Exposure to ≥10 μg mL–1 verapamil led to a significant decrease of C. albicans hyphal cells. The ability to adhere to a polystyrene surface and buccal epithelial cells was inhibited by exposure to ≥20 μg mL–1 verapamil. Detection of the Hwp1–green fluorescent protein fusion protein showed that verapamil inhibited expression and transport of Hwp1, indicating its activity against both the regulation network of morphogenesis‐associated proteins and the secretory pathway in C. albicans. Moreove...
Source: FEMS Yeast Research - March 1, 2014 Category: Research Authors: Qilin Yu, Xiaohui Ding, Bing Zhang, Ning Xu, Chang Jia, Jiwei Mao, Biao Zhang, Laijun Xing, Mingchun Li Tags: Research Paper Source Type: research
The fraction of cells that resume growth after acetic acid addition is a strain–dependent parameter of acetic acid tolerance in Saccharomyces cerevisiae
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - March 1, 2014 Category: Research Authors: Steve Swinnen, Miguel Fernández Niño, Daniel González‐Ramos, Antonius J. A. Maris, Elke Nevoigt Tags: Research Paper Source Type: research
Genome Structure and Dynamics of the Yeast Pathogen Candida glabrata
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 16, 2014 Category: Research Authors: Khadija Mohamed Ahmad, Janez Kokošar, Xiaoxian Guo, Zhenglong Gu, Olena P. Ishchuk, Jure Piškur Tags: MiniReview Source Type: research
Yeast lipid metabolism at a glance
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 13, 2014 Category: Research Authors: Lisa Klug, Günther Daum Tags: MiniReview Source Type: research
Calcineurin inhibitors suppress the high‐temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: A new method of screening for calcineurin inhibitors
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 13, 2014 Category: Research Authors: Shota Uesugi, Daisuke Watanabe, Moe Kitajima, Ryo Watanabe, Yumi Kawamura, Motoko Ohnishi, Hiroshi Takagi, Ken‐ichi Kimura Tags: Research Paper Source Type: research
Regulation of Saccharomyces cerevisiae MEF1 by Hda1p affects salt resistance of bdf1Δ mutant
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 13, 2014 Category: Research Authors: Lei Chen, Mingpeng Wang, Jin Hou, Liangyu Liu, Jiafang Fu, Yu Shen, Zhaojie Zhang, Xiaoming Bao Tags: Research Paper Source Type: research
Issue Information
(Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 7, 2014 Category: Research Tags: Issue Information Source Type: research
FK520 interacts with the discrete intra‐helical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole resistant clinical isolates of Candida albicans
This study establishes the molecular basis of interaction of FK520 with Cdr1 protein, which is one of the major ABC multidrug transporters of C. albicans. For this, we have exploited, an in‐house library of Cdr1 protein consisting of 252 mutant variants where the entire primary structure of the 2 transmembrane domains comprising of 12 transmembrane helices were subjected to alanine scanning. With these mutant variants of Cdr1 protein, we could identify the critical amino acids of the transporter protein which if replaced with alanine, not only abrogated FK520 dependent competitive inhibition of drug efflux but simultaneo...
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Shweta Nim, Manpreet Kaur Rawal, Rajendra Prasad Tags: Research Paper Source Type: research
The putative transcription factor CaRtg3 is involved in tolerance to cations and antifungal drugs as well as serum‐induced filamentation in Candida albicans
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Hongbo Yan, Yunying Zhao, Linghuo Jiang Tags: Research Paper Source Type: research
Three agt1 transporters from brewer's yeasts exhibit different temperature‐dependencies for maltose transport over the range of brewery temperatures (0°c to 20°c)
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Virve Vidgren, Kaarina Viljanen, Laura Mattinen, Jari Rautio, John Londesborough Tags: Research Paper Source Type: research
Quantitative phenotypic analysis of multi‐stress response in Zygosaccharomyces rouxii complex
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Lisa Solieri, Tikam Chand Dakal, Silvio Bicciato Tags: Research Paper Source Type: research
A broad‐range yeast expression system reveals Arxula adeninivorans expressing a fungal self‐sufficient cytochrome P450 monooxygenase as an excellent whole cell biocatalyst
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Chrispian W. Theron, Michel Labuschagné, Rama Krishna Gudiminchi, Jacobus Albertyn, Martha S. Smit Tags: Research Paper Source Type: research
Functional integration of multiple genes into the genome of the oleaginous yeast Rhodosporidium toruloides
This article is protected by copyright. All rights reserved. (Source: FEMS Yeast Research)
Source: FEMS Yeast Research - February 1, 2014 Category: Research Authors: Xinping Lin, Yanan Wang, Sufang Zhang, Zhiwei Zhu, Yongjin J. Zhou, Fan Yang, Wenyi Sun, Xueying Wang, Zongbao Kent Zhao Tags: Research Paper Source Type: research
Atg21 regulates pexophagy via its PI(3)P‐binding activity in Pichia pastoris
Abstract
Pexophagy is a selective degradation pathway of peroxisomes. In the present study, we revealed that PpAtg21 was required for pexophagy in the methylotrophic yeast Pichia pastoris. PpAtg21 was essential for efficient lipidation of Atg8 and for de novo synthesis of pexophagic membranes. In contrast to PpAtg18, PpAtg21 was not necessary for vacuolar fission nor invagination during micropexophagy. PpAtg21 specifically bound to PI(3)P, but not to PI(3,5)P2 in vitro, and the localization analyses matched with this phosphoinositide‐binding specificity. The mutant which lost the lipid‐binding activity showed defect in...
Source: FEMS Yeast Research - January 23, 2014 Category: Research Authors: Naoki Tamura, Masahide Oku, Yasuyoshi Sakai Tags: Research Article Source Type: research
