Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
In this study we tested the hypothesis that avolition is related to altered connectivity within dopaminergic cortico-striatal circuits involved in motivation processes. Since dopamine input to these circuits derives mostly from the ventro-tegmental area (VTA), we investigated the relationships between the resting-state functional connectivity (RS-FC) of the VTA and avolition in twenty-six subjects with schizophrenia (SCZ), treated with second-generation antipsychotics only, compared to twenty-two healthy controls (HC). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Giulia Maria Giordano, Mario Stanziano, Michele Papa, Armida Mucci, Anna Prinster, Andrea Soricelli, Silvana Galderisi Source Type: research
Increased methylation at an unexplored glucocorticoid responsive element within exon 1D of NR3C1 gene is related to anxious-depressive disorders and decreased hippocampal connectivity
Among the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities. Methylation at the exon 1F of the glucocorticoid receptor gene NR3C1 has been associated with both early stress exposure and risk for developing a psychiatric disorder; however, other NR3C1 promoter regions have been underexplored. Exon 1D emerges as a suggestive new target in stress-related disorders epigenetically sensitive to early adversity. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Helena Palma-Gudiel, Aldo C órdova-Palomera, Cristian Tornador, Carles Falcón, Núria Bargalló, Gustavo Deco, Lourdes Fañanás Source Type: research
Neurocognitive correlates of medication-induced addictive behaviours in Parkinson's disease: A systematic review
Dopaminergic medication can induce severe addictive behaviours (e.g., pathological gambling) in susceptible Parkinson's disease (PD) patients. It is still unknown which particular neurocognitive processes become exacerbated or dysfunctional in PD patients with addictive behaviours. We sought to systematically review the relevant literature to identity potential neurocognitive correlates of medication-induced addictive behaviours in PD. We framed our review around neurocognitive processes central to four dominant accounts of substance addiction: ‘aberrant learning’, ‘incentive sensitization’, ‘impulsivity to compu...
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Andrew Dawson, Nadeeka N. Dissanayaka, Andrew Evans, Antonio Verdejo-Garcia, Trevor T.J. Chong, Giuseppe Frazzitta, Davide Ferrazzoli, Paola Ortelli, Murat Y ücel, Adrian Carter Tags: REVIEW Source Type: research
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
In this study we tested the hypothesis that avolition is related to altered connectivity within dopaminergic cortico-striatal circuits involved in motivation processes. Since dopamine input to these circuits derives mostly from the ventro-tegmental area (VTA), we investigated the relationships between the resting-state functional connectivity (RS-FC) of the VTA and avolition in twenty-six subjects with schizophrenia (SCZ), treated with second-generation antipsychotics only, compared to twenty-two healthy controls (HC). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Giulia Maria Giordano, Mario Stanziano, Michele Papa, Armida Mucci, Anna Prinster, Andrea Soricelli, Silvana Galderisi Source Type: research
Increased methylation at an unexplored glucocorticoid responsive element within exon 1D of NR3C1 gene is related to anxious-depressive disorders and decreased hippocampal connectivity
Among the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities. Methylation at the exon 1F of the glucocorticoid receptor gene NR3C1 has been associated with both early stress exposure and risk for developing a psychiatric disorder; however, other NR3C1 promoter regions have been underexplored. Exon 1D emerges as a suggestive new target in stress-related disorders epigenetically sensitive to early adversity. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Helena Palma-Gudiel, Aldo C órdova-Palomera, Cristian Tornador, Carles Falcón, Núria Bargalló, Gustavo Deco, Lourdes Fañanás Source Type: research
Editorial Board
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
ECNP Calendar of Meeetings
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
Contents
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
Editorial Board
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
ECNP Calendar of Meeetings
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
Contents
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 1, 2018 Category: Psychiatry & Psychology Source Type: research
Baseline serum vascular endothelial growth factor levels predict treatment response to antipsychotic medication in patients with schizophrenia
Vascular endothelial growth factor (VEGF) is implicated in angiogenesis, blood flow, and neuroplasticity, which have previously been shown to contribute to schizophrenia and the mechanisms of action of antipsychotic medication. The aim of the present study was to investigate whether baseline serum VEGF levels predict treatment responses to antipsychotic medication. Drug-free adults with schizophrenia were administered monotherapy with atypical antipsychotic drugs for 6 weeks. Participants ’ psychiatric symptoms were assessed using the positive and negative symptom scale (PANSS) before and after treatment. (Source: Europe...
Source: European Neuropsychopharmacology - March 27, 2018 Category: Psychiatry & Psychology Authors: Wenhuan Xiao, Qiongqiong Zhan, Fei Ye, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang Source Type: research
Functional mechanism of ASP5736, a selective serotonin 5-HT5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia
In this study, using behavioral, immunohistochemical, electrophysiological and microdialysis techniques, we examined the mechanism by which ASP5736, a novel and selective 5-HT5A receptor antagonist, exerts a positive effect in animal models of cognitive impairment. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - March 20, 2018 Category: Psychiatry & Psychology Authors: Mayako Yamazaki, Noriyuki Yamamoto, Junko Yarimizu, Mayuko Okabe, Ai Moriyama, Masako Furutani, Monica M. Marcus, Torgny H. Svensson, Katsuya Harada Source Type: research
Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine
Three types of antipsychotics, typical (e.g. haloperidol), atypical (e.g. clozapine), and dopamine partial agonist (e.g. aripiprazole), are administered for treatment of schizophrenia. These antipsychotics have different efficacy and side-effect profiles. We investigated whether aripiprazole, clozapine, and haloperidol differentially regulate the dendritic spine through the AKT-GSK-3 beta cascade. Dissociated cortical neurons from Sprague-Dawley rats were prepared and cultured for 28 days. Aripiprazole, clozapine, or haloperidol was administered to the rat cortical neurons. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - March 20, 2018 Category: Psychiatry & Psychology Authors: Manabu Takaki, Masafumi Kodama, Yutaka Mizuki, Hiroki Kawai, Bunta Yoshimura, Makiko Kishimoto, Shinji Sakamoto, Yuko Okahisa, Norihito Yamada Source Type: research
