White matter disruptions in patients with bipolar disorder
Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 17, 2018 Category: Psychiatry & Psychology Authors: Lucija Abramovic, Marco P.M. Boks, Annabel Vreeker, Sanne Verkooijen, Annet H. van Bergen, Roel A. Ophoff, Ren é S. Kahn, Neeltje E.M. van Haren Source Type: research
Editorial Board
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 1, 2018 Category: Psychiatry & Psychology Source Type: research
ECNP Calendar of Meeetings
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 1, 2018 Category: Psychiatry & Psychology Source Type: research
Contents
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 1, 2018 Category: Psychiatry & Psychology Source Type: research
PLACID study: A randomized trial comparing the efficacy and safety of inhaled loxapine versus intramuscular aripiprazole in acutely agitated patients with schizophrenia or bipolar disorder
The aim of the study was to investigate the efficacy and safety of inhaled loxapine compared with the intramuscular (IM) antipsychotic aripiprazole in acutely agitated patients with schizophrenia or bipolar I disorder. PLACID was an assessor-blind, parallel-group trial conducted in 23 centres in the Czech Republic, Germany, Spain, and Russia. Patients (aged 18 –65 years) diagnosed with schizophrenia or bipolar I disorder experiencing acute agitation (Clinical Global Impression [CGI]-Severity score ≥ 4) while hospitalized or attending an emergency room were randomized to receive up to two doses of inhaled loxapine 9.1...
Source: European Neuropsychopharmacology - May 1, 2018 Category: Psychiatry & Psychology Authors: Luis San, Gemma Estrada, Natalia Oudovenko, Francisco Monta ñés, Natalia Dobrovolskaya, Olga Bukhanovskaya, Mikhail Popov, Eduard Vieta Source Type: research
Lower dopamine tone in the striatum is associated with higher body mass index
Existing literature suggests that striatal dopamine (DA) tone may be altered in individuals with higher body mass index (BMI), but evidence accrued so far only offers an incomplete view of their relationship. Here, we characterized striatal DA tone using more comprehensive measures within a larger sample than previously reported. In addition, we explored if there was a relationship between striatal DA tone and disinhibited eating. 60 healthy participants underwent a 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET) scan. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 25, 2018 Category: Psychiatry & Psychology Authors: Ying Lee, Nils B. Kroemer, Liane Oehme, Bettina Beuthien-Baumann, Thomas Goschke, Michael N. Smolka Source Type: research
Comorbid thyroid disease in patients with major depressive disorder - results from The European Group for the Study of Resistant Depression (GSRD)
This multicenter study of the European Group for the Study of Resistant Depression (GSRD) aimed to explore the association between major depressive disorder (MDD) and comorbid thyroid disease. A total number of 1410 patients` characteristics in terms of demographic and clinical information were compared between MDD subjects with and without concurrent thyroid disease using descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses. We determined a point prevalence rate for comorbid hypothyroidism of 13.2% and 1.6% for comorbid hyperthyroidism respectively. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 25, 2018 Category: Psychiatry & Psychology Authors: Gernot Fugger, Markus Dold, Lucie Bartova, Alexander Kautzky, Daniel Souery, Julien Mendlewicz, Alessandro Serretti, Joseph Zohar, Stuart Montgomery, Richard Frey, Siegfried Kasper Tags: SHORT COMMUNICATION Source Type: research
Psilocybin modulates functional connectivity of the amygdala during emotional face discrimination
Recent studies suggest that the antidepressant effects of the psychedelic 5-HT2A receptor agonist psilocybin are mediated through its modulatory properties on prefrontal and limbic brain regions including the amygdala. To further investigate the effects of psilocybin on emotion processing networks, we studied for the first-time psilocybin's acute effects on amygdala seed-to-voxel connectivity in an event-related face discrimination task in 18 healthy volunteers who received psilocybin and placebo in a double-blind balanced cross-over design. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 25, 2018 Category: Psychiatry & Psychology Authors: O. Grimm, R. Kraehenmann, K.H. Preller, E. Seifritz, F.X. Vollenweider Source Type: research
Striatal dopamine release and impaired reinforcement learning in adults with 22q11.2 deletion syndrome
This study aims to examine RL and the potential association with striatal DA-ergic neuromodulation in 22q11DS. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 24, 2018 Category: Psychiatry & Psychology Authors: Esther D.A. van Duin, Zuzana Kasanova, Dennis Hernaus, Jenny Ceccarini, Alexander Heinzel, Felix Mottaghy, Siamak Mohammadkhani-Shali, Oliver Winz, Michael Frank, Merrit C.H. Beck, Jan Booij, Inez Myin-Germeys, Th érèse van Amelsvoort Source Type: research
Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine – A randomized trial
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long –term impact on blood parameters has not yet been described in clinical studies. Here we investigated potential sustained effects of ketamine administration (0.5 mg/kg ketamine racemate) on hematological and biochemical values in plasma and serum in a randomized double–blinded study. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 24, 2018 Category: Psychiatry & Psychology Authors: Lejla Colic, Marie Woelfer, Merima Colic, Anna Linda Leutritz, Thomas Liebe, Luisa Fensky, Zumrut Duygu Sen, Meng Li, Juliane Hoffmann, Moritz A Kretzschmar, Berend Isermann, Martin Walter Source Type: research
Striatal dopamine release and impaired reinforcement learning in adults with 22q11.2 deletion syndrome
This study aims to examine RL and the potential association with striatal DA-ergic neuromodulation in 22q11DS. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 24, 2018 Category: Psychiatry & Psychology Authors: Esther D.A. van Duin, Zuzana Kasanova, Dennis Hernaus, Jenny Ceccarini, Alexander Heinzel, Felix Mottaghy, Siamak Mohammadkhani-Shali, Oliver Winz, Michael Frank, Merrit C.H. Beck, Jan Booij, Inez Myin-Germeys, Th érèse van Amelsvoort Source Type: research
Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine – A randomized trial
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long –term impact on blood parameters has not yet been described in clinical studies. Here we investigated potential sustained effects of ketamine administration (0.5 mg/kg ketamine racemate) on hematological and biochemical values in plasma and serum in a randomized double–blinded study. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 24, 2018 Category: Psychiatry & Psychology Authors: Lejla Colic, Marie Woelfer, Merima Colic, Anna Linda Leutritz, Thomas Liebe, Luisa Fensky, Zumrut Duygu Sen, Meng Li, Juliane Hoffmann, Moritz A Kretzschmar, Berend Isermann, Martin Walter Source Type: research
Letter to the Editor: Response to Costa et al.
We welcome the comments from Costa et al. relating to our systematic review. In respect of patient-tailored dosing, the ultimate aim of any drug should be personalised dosing which allows the attainment of drug concentrations in the blood (and at the site of action) that both optimise the efficacy and minimise toxicity for each patient. However, this is not usual practice, since most drugs are used on the basis of “one-dose-fits-all”. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - April 12, 2018 Category: Psychiatry & Psychology Authors: Andrew Thompson, Lynn Owens, Paul Richardson, Munir Pirmohamed Source Type: research
Neurocognitive correlates of medication-induced addictive behaviours in Parkinson's disease: A systematic review
Dopaminergic medication can induce severe addictive behaviours (e.g., pathological gambling) in susceptible Parkinson's disease (PD) patients. It is still unknown which particular neurocognitive processes become exacerbated or dysfunctional in PD patients with addictive behaviours. We sought to systematically review the relevant literature to identity potential neurocognitive correlates of medication-induced addictive behaviours in PD. We framed our review around neurocognitive processes central to four dominant accounts of substance addiction: ‘aberrant learning’, ‘incentive sensitization’, ‘impulsivity to compu...
Source: European Neuropsychopharmacology - April 10, 2018 Category: Psychiatry & Psychology Authors: Andrew Dawson, Nadeeka N. Dissanayaka, Andrew Evans, Antonio Verdejo-Garcia, Trevor T.J. Chong, Giuseppe Frazzitta, Davide Ferrazzoli, Paola Ortelli, Murat Y ücel, Adrian Carter Tags: REVIEW Source Type: research
