Nociceptin and the NOP receptor in aversive learning in mice
This study examined the effects of the NOP agonists N/OFQ and the synthetic agonist Ro 64 –6198, the antagonists NNN and NalBzoH, as well as deletion of the Pronociceptin gene on emotional memory in mice. The animals were tested in the passive avoidance (PA) task, dependent on hippocampal and amygdala functions. N/OFQ injected intraventricularly (i.c.v.) prior to training produced a bi phasic effect on PA retention; facilitation at a low dose and impairment at higher doses. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 25, 2017 Category: Psychiatry & Psychology Authors: Abdu Adem, Nather Madjid, Ulrika Kahl, Sarah Holst, Bassem Sadek, Johan Sandin, Lars Terenius, Sven Ove Ögren Source Type: research
Impaired contrast sensitivity at low spatial frequency in cannabis users with early onset
The regular use of cannabis generates pronounced cognitive disorders, especially in users who begin before the age of 15 –16. However, less is known about the impact of regular cannabis on visual function, especially in the case of early onset. Cannabinoid receptors (CB1) are expressed in areas of the visual system, like the thalamus and primary cortex, which might originate sensory disorders. Hence, we measured con trast sensitivity (CS) in three groups, i.e. cannabis users with late onset of cannabis use (after 16 years old), cannabis users with early onset”. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 12, 2017 Category: Psychiatry & Psychology Authors: Laurence Lalanne, Eglantine Ferrand-Devouge, Sebastien Kirchherr, Lucie Rauch, Estelle Koning, Claude Speeg, Vincent Laprevote, Anne Giersch Source Type: research
Serotonin transporter density in binge eating disorder and pathological gambling: A PET study with [11C]MADAM
Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear. Given the crucial role of serotonin in a number of psychiatric disorders, we aimed to compare brain serotonergic function among individuals with BED, PG and healthy controls. Seven BED patients, 13 PG patients and 16 healthy controls were scanned with high-resolution positron emission tomography (PET) using the serotonin transporter (SERT) tracer [11C]MADAM. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 9, 2017 Category: Psychiatry & Psychology Authors: Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Riitta Parkkola, Hannu Alho, Eveliina Arponen, Valtteri Kaasinen Source Type: research
Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis
In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment ( “add-on” OR "adjunctive" OR "augmentation"). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 6, 2017 Category: Psychiatry & Psychology Authors: Cora Schefft, Laura L. Kilarski, Tom Bschor, Stephan K öhler Tags: Review Source Type: research
How addictive are gabapentin and pregabalin? A systematic review
In the last ten years, gabapentin and pregabalin have been becoming dispensed broadly and sold on black markets, thereby, exposing millions to potential side-effects. Meanwhile, several pharmacovigilance-databases have warned for potential abuse liabilities and overdose fatalities in association with both gabapentinoids. To evaluate their addiction risk in more detail, we conducted a systematic review on PubMed/Scopus and included 106 studies. We did not find convincing evidence of a vigorous addictive power of gabapentinoids which is primarily suggested from their limited rewarding properties, marginal notes on relapses, ...
Source: European Neuropsychopharmacology - October 6, 2017 Category: Psychiatry & Psychology Authors: U. Bonnet, N. Scherbaum Tags: REVIEW Source Type: research
Editorial Board
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Source: European Neuropsychopharmacology - September 26, 2017 Category: Psychiatry & Psychology Source Type: research
ECNP Calendar of Events
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Source: European Neuropsychopharmacology - September 26, 2017 Category: Psychiatry & Psychology Source Type: research
Contents
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Source: European Neuropsychopharmacology - September 26, 2017 Category: Psychiatry & Psychology Source Type: research
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Source: European Neuropsychopharmacology - September 26, 2017 Category: Psychiatry & Psychology Source Type: research
Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour
In this study we compare the impact of decreased nitric NO signalling upon behaviour and neurobiology using both zebrafish and mouse. nitric oxide synthase mutant (nos1 −/−) zebrafish show significantly reduced aggression and an increase in anxiety-like behaviour without altered production of the stress hormone cortisol. Nos1−/− mice also exhibit decreased aggression and are hyperactive in an open field test. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - September 23, 2017 Category: Psychiatry & Psychology Authors: H éctor Carreño Gutiérrez, Aet O’Leary, Florian Freudenberg, Giorgio Fedele, Rob Wilkinson, Eleanor Markham, Freek van Eeden, Andreas Reif, William H.J. Norton Source Type: research
Neuropeptide S overcomes short term memory deficit induced by sleep restriction by increasing prefrontal cortex activity
The objective of the present study was to find common cerebral pathways in sleep restriction and NPS action in order to ultimately antagonize SR effect on memory.The STM was assessed using a spontaneous spatial alternation task in a T-maze. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - September 20, 2017 Category: Psychiatry & Psychology Authors: Julien Thomasson, Fr édéric Canini, Betty Poly-Thomasson, Marion Trousselard, Sylvie Granon, Frédéric Chauveau Source Type: research
Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus
Acute γ-aminobutyric acid (GABA) disinhibition in the posterior hypothalamus (PH) elicits defensive reactions that are considered anxiety- and panic attack-like behaviour, and these defensive reactions are followed by antinociception. Evidence indicates that the PH connects with the medial prefrontal cor tex, particularly the anterior cingulate cortex (ACC), which seems to regulate these unconditioned fear-induced defensive responses. However, few studies have shown the participation of cortical regions in the control of behavioural and antinociceptive responses organised by diencephalic structures. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - September 20, 2017 Category: Psychiatry & Psychology Authors: Luiz Luciano Falconi-Sobrinho, Tayllon dos Anjos-Garcia, Ricardo de Oliveira, Norberto Cysne Coimbra Source Type: research
Exogenous testosterone in a non-social provocation paradigm potentiates anger but not behavioral aggression
The objective of the current study was to investigate the influence of testosterone on non-social aggression in a double-blind, placebo-controlled experiment including 90 healthy male participants. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - September 19, 2017 Category: Psychiatry & Psychology Authors: Despina Panagiotidis, Benjamin Clemens, Ute Habel, Frank Schneider, Isabella Schneider, Lisa Wagels, Mikhail Votinov Source Type: research
Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies
The popularity of baclofen as an anti-craving agent in the treatment of alcohol use disorders (AUDs) has increased, especially in patients with established liver disease. However, evidence-based guidelines to inform practice are lacking. The aim of this systematic review is explore the prescribing practices of baclofen in AUD treatment. Electronic databases were searched for relevant articles from 2002. Assessment of eligibility criteria for inclusion was performed independently by two investigators. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - September 19, 2017 Category: Psychiatry & Psychology Authors: Andrew Thompson, Lynn Owens, Paul Richardson, Munir Pirmohamed Tags: REVIEW Source Type: research
