Diabetes and Vascular Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Osteoprotegerin is independently associated with metabolic syndrome and microvascular complications in type 2 diabetes mellitus
Conclusion: Higher OPG levels were associated with risk of MS and microvascular complications. Studies are needed to test whether OPG could be a useful biomarker identifying patients at risk of vascular complications and whether further exploration of this pathway may lead novel therapeutic options. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Tavintharan, S., Pek, L. T. S., Liu, J. J., Ng, X. W., Yeoh, L. Y., Su Chi, L., Chee Fang, S. Tags: Brief Report Source Type: research

Optimal target range for blood glucose in hyperglycaemic patients in a neurocritical care unit
Conclusion: A differential association is evident between glucose levels and mortality in diabetes and stress-related hyperglycaemia patients. However, given the observational nature of our work, no clinical recommendations can be given and prospective studies are required to further investigate these findings. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Guo, Y.-J., Zhou, Y., Zhang, S.-Y., Wei, Q., Huang, Y., Xia, W.-Q., Wang, S.-H. Tags: Original Articles Source Type: research

Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?
Conclusion: In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Senechal, M., Ayers, C. R., Szczepaniak, L. S., Gore, M. O., See, R., Abdullah, S. M., Berry, J. D., McGuire, D. K., McGavock, J. M. Tags: Original Articles Source Type: research

Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes
Conclusion: Despite the protective effect against vascular diabetes complications, a borderline increased risk of stroke was observed with Hp 1-1 in type 1 diabetes. This mixed Hp effect on cardiovascular risk by outcome studied merits further investigation and cautions against the universal application of preventive therapies across all Hp genotypes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Costacou, T., Secrest, A. M., Ferrell, R. E., Orchard, T. J. Tags: Original Articles Source Type: research

Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes
This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-in...
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Scheede-Bergdahl, C., Bergdahl, A., Schjerling, P., Qvortrup, K., Koskinen, S. O., Dela, F. Tags: Original Articles Source Type: research

The effects of GLP-1 analogues, DPP-4 inhibitors and SGLT2 inhibitors on the renal system
Diabetic nephropathy (DN) affects an estimated 20%–40% of patients with type 2 diabetes mellitus (T2DM). Key modifiable risk factors for DN are albuminuria, anaemia, dyslipidaemia, hyperglycaemia and hypertension, together with lifestyle factors, such as smoking and obesity. Early detection and treatment of these risk factors can prevent DN or slow its progression, and may even induce remission in some patients. DN is generally preceded by albuminuria, which frequently remains elevated despite treatment in patients with T2DM. Optimal treatment and prevention of DN may require an early, intensive, multifactorial appro...
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Schernthaner, G., Mogensen, C. E., Schernthaner, G.-H. Tags: Review Article Source Type: research

Cluster randomised controlled trial evaluation of a Link Worker-delivered intervention to improve uptake of diabetic retinopathy screening in a South Asian population
We describe a cluster randomised controlled trial conducted in 10 general practitioner (GP) surgeries in Coventry, UK, during 2007 which aimed to evaluate the use of a Link Worker–delivered intervention to improve attendance. The intervention consisted of a simple telephone reminder with the main outcome measure being attendance at diabetic retinopathy screening. We found a statistically significant difference between mean attendance proportions for intervention (0.89) and control (0.74) practices: difference (95% confidence interval (CI)) 0.15 (0.04–0.27), t = 3.03, p = 0.0162; this difference remained signifi...
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Bush, K., Thomas, R., Raymond, N. T., Sankar, S., Barker, P. J., O'Hare, J. P. Tags: Brief Reports Source Type: research

The DPP-4 inhibitor sitagliptin and endothelial function in patients with acute coronary syndromes and newly detected glucose perturbations: A report from the BEGAMI study
Conclusion: Sitagliptin did not improve endothelial function in patients with ACS and newly detected glucose perturbations. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Hage, C., Brismar, K., Lundman, P., Norhammar, A., Ryden, L., Mellbin, L. Tags: Brief Reports Source Type: research

The relationship between blood pressure and sciatic nerve blood flow velocity in rats with insulin-treated experimental diabetes
Peripheral nerve blood flow (NBF) does not autoregulate but, instead, responds passively to changes in mean arterial pressure (MAP). How this relationship is impacted by insulin-treated experimental diabetes (ITED) is unknown. We tested the hypothesis that ITED will reduce NBF across a range of MAP in Sprague Dawley rats. Following 10 weeks of control or ITED conditions, conscious MAP (tail-cuff) was measured, and under anaesthesia, the MAP (carotid artery catheter, pressure transducer) and NBF (Doppler ultrasound, 40 MHz) responses to sodium nitroprusside (60 µg/kg) and phenylephrine (12 µg/kg) infusion were r...
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Olver, T. D., Grise, K. N., McDonald, M. W., Dey, A., Allen, M. D., Rice, C. L., Lacefield, J. C., Melling, C. J., Noble, E. G., Shoemaker, J. K. Tags: Original Articles Source Type: research

Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1{alpha} expression
Hyperglycaemia and hypoxia play essential pathophysiological roles in diabetes. We determined whether hyperglycaemia influences endothelial cell growth under hypoxic conditions in vitro. Using a Ruskinn Invivo2 400 Hypoxia Workstation, bovine aortic endothelial cells (BAEC) were exposed to high glucose concentrations (25 mM glucose) under normoxic or hypoxic conditions before cell growth (balance of proliferation and apoptosis) was assessed by fluorescence-activated cell sorting (FACS) analysis, proliferating cell nuclear antigen (pCNA), Bcl-xL and caspase-3 protein expression and activity. Hypoxia increased hypoxia respon...
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Gao, W., Ferguson, G., Connell, P., Walshe, T., O'Brien, C., Redmond, E. M., Cahill, P. A. Tags: Original Articles Source Type: research

Plasma semicarbazide-sensitive amine oxidase activity in type 1 diabetes is related to vascular and renal function but not to glycaemia
Conclusion: In T1DM, SSAO activity correlates with renal dysfunction, but not with glycaemia, and may promote vascular inflammation and be a therapeutic target. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Januszewski, A. S., Mason, N., Karschimkus, C. S., Rowley, K. G., Best, J. D., O'Neal, D. N., Jenkins, A. J. Tags: Original Articles Source Type: research

Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-{beta} signalling via secretion of bone morphogenetic protein 7
Conclusion: MSCs ameliorated glomerular fibrosis in vivo and in vitro by inhibiting TGF-β/Smad signalling pathway via secretion of BMP7. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Lv, S., Liu, G., Sun, A., Wang, J., Cheng, J., Wang, W., Liu, X., Nie, H., Guan, G. Tags: Original Articles Source Type: research

Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats
Although urinary albumin is the well-known non-invasive marker for diabetic nephropathy, its sensitivity is relatively low. To select more adequate marker, we examined whether urinary tubular markers were more sensitive than albumin using spontaneous type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The OLETF rats exhibited histopathological alterations in glomeruli and tubules at 14 weeks of age, but there were no significant differences in the urinary albumin between OLETF and control, Long-Evans Tokushima Otsuka (LETO), rats at 10–16 weeks of age. In the OLETF rats, urinary excretions of N-acetyl-&be...
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Hosohata, K., Ando, H., Takeshita, Y., Misu, H., Takamura, T., Kaneko, S., Fujimura, A. Tags: Original Articles Source Type: research

Combined incubation of platelets and endothelial cells with glycated albumin: Altered thrombogenic and inflammatory responses
Diabetes mellitus is a salient risk factor for the development of cardiovascular diseases (CVDs). Part of this risk is associated with the presence of advanced glycation end products (AGEs), which have been shown to up-regulate platelet or endothelial cell inflammatory and thrombogenic responses that are associated with CVDs. However, platelets perform mechanisms that alter endothelial cell inflammatory and thrombogenic responses, and endothelial cells perform similar mechanisms on platelets. Thus, our goal was to evaluate platelet and endothelial cell inflammatory and thrombogenic reactions that AGEs elicit during concurr...
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Rubenstein, D. A., Maria, Z., Yin, W. Tags: Original Articles Source Type: research

Preoperative glucose level has different effects on the endogenous extracellular matrix-related gene expression in saphenous vein of type 2 diabetic patients undergoing coronary surgery
Conclusion: This study suggested that different preoperative diabetic status affected the expression of ECM-related genes in SV. ECM-related genes were more significantly imbalanced in diabetic patients with uncontrolled preoperative blood glucose than those with well-controlled preoperative blood glucose. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 16, 2014 Category: Endocrinology Authors: Sun, Y., Lin, Z., Ding, W., Wei, Q., Shi, Y., Wang, C. Tags: Original Articles Source Type: research