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Magnitude, treatment, and impact of diabetes mellitus in patients hospitalized with non-ST segment elevation myocardial infarction: A community-based study
Purpose of the study: To examine differences in the characteristics, treatment practices and in-hospital outcomes of patients with and without previously diagnosed diabetes hospitalized for non-ST segment elevation myocardial infarction. Key methods: The study cohort consisted of 3916 patients diagnosed with non-ST segment elevation myocardial infarction at all 11 central MA medical centres between 1999 and 2009, of whom 1475 (38%) had been previously diagnosed with diabetes. Main results: Diabetic patients were more likely to have received treatment with effective cardiac medications, and to have undergone coronary bypa...
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Awad, H. H., Tisminetzky, M., Metry, D., McManus, D., Yarzebski, J., Gore, J. M., Goldberg, R. J. Tags: Original Articles Source Type: research

Incidence, characteristics and impact of hypoglycaemia in patients receiving intensified treatment for inadequately controlled type 2 diabetes mellitus
Conclusion: Case-by-case evaluation of patients as well as appropriate selection of antidiabetic pharmacotherapy and blood glucose treatment goals could maximize the benefits while reducing the risks of antidiabetic treatment. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Tschöpe, D., Bramlage, P., Schneider, S., Gitt, A. K. Tags: Original Articles Source Type: research

Do different definitions modify the gender-specific associations of metabolic syndrome with cardiovascular risk factors?
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Zhou, Y., Dong, G.-H. Tags: Letters to the Editor Source Type: research

Metabolic syndrome: Different definitions and gender-specific associations with cardiovascular risk factors
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Katsiki, N., Athyros, V. G., Mikhailidis, D. P. Tags: Letters to the Editor Source Type: research

Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer's disease
In conclusion, this work revealed the proteome of endothelial microparticles in mimic diabetes condition and provided a new proteomic evidence for Alzheimer’s disease to be counted as the type 3 diabetes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Zu, L., Niu, C., Li, J., Shan, L., Li, L., Zhang, D., Willard, B., Zheng, L. Tags: Brief Reports Source Type: research

Prior treatment with dipeptidyl peptidase 4 inhibitors is associated with better functional outcome and lower in-hospital mortality in patients with type 2 diabetes mellitus admitted with acute ischaemic stroke
In conclusion, prior treatment with dipeptidyl peptidase 4 inhibitors in patients with acute ischaemic stroke appears to be associated with better functional outcome and lower mortality risk. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Tziomalos, K., Bouziana, S. D., Spanou, M., Kostaki, S., Papadopoulou, M., Giampatzis, V., Dourliou, V., Kostourou, D.-T., Savopoulos, C., Hatzitolios, A. I. Tags: Brief Reports Source Type: research

Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINA-T2D™ trial
Efficacy, Safety & Modification of Albuminuria in Type 2 Diabetes Subjects with Renal Disease with LINAgliptin (MARLINA–T2D™), a multicentre, multinational, randomized, double-blind, placebo-controlled, parallel-group, phase 3b clinical trial, aims to further define the potential renal effects of dipeptidyl peptidase-4 inhibition beyond glycaemic control. A total of 350 eligible individuals with inadequately controlled type 2 diabetes and evidence of renal disease are planned to be randomized in a 1:1 ratio to receive either linagliptin 5 mg or placebo in addition to their stable glucose-lowering background...
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Groop, P.-H., Cooper, M. E., Perkovic, V., Sharma, K., Schernthaner, G., Haneda, M., Hocher, B., Gordat, M., Cescutti, J., Woerle, H.-J., von Eynatten, M. Tags: Study Design Source Type: research

Improved cognitive, affective and anxiety measures in patients with chronic systemic disorders following structured physical activity
Mental illnesses are frequent co-morbid conditions in chronic systemic diseases. High incidences of depression, anxiety and cognitive impairment complicate cardiovascular and metabolic disorders such as hypertension and diabetes mellitus. Lifestyle changes including regular exercise have been advocated to reduce blood pressure and improve glycaemic control. The purpose of this project was to evaluate the effect of physical training on the most prevalent corollary psychiatric problems in patients with chronic organic ailments. This longitudinal study assessed the mental health of hypertensive (age: 57 ± 8 years) and/...
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Teixeira, R. B., Marins, J. C. B., de Sa Junior, A. R., de Carvalho, C. J., da Silva Moura, T. A., Lade, C. G., Rizvanov, A. A., Kiyasov, A. P., Mukhamedyarov, M. A., Zefirov, A. L., Palotas, A., Lima, L. M. Tags: Original Articles Source Type: research

Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis
As one of the vascular complications of type 2 diabetes mellitus, the incidence of diabetes retinopathy is greatly increasing worldwide. Both genetic and environmental factors are involved in the pathologies. A meta-analysis was conducted to assess the association between transcription factor 7-like 2 polymorphism (rs7903146) and type 2 diabetic retinopathy. Published literature from PubMed, Web of Science and China National Knowledge Infrastructure were retrieved. Pooled odds ratios with 95% confidence intervals were calculated to estimate the strength of the association. Eight studies including 6422 participants were inc...
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Ding, Y., Hu, Z., Yuan, S., Xie, P., Liu, Q. Tags: Original Articles Source Type: research

Cardiorespiratory fitness is a stronger indicator of cardiometabolic risk factors and risk prediction than self-reported physical activity levels
In conclusion, from this preliminary observational study, cardiorespiratory fitness levels reveal a greater number of associations with markers of cardiovascular disease or type 2 diabetes mellitus compared to physical activity determined by the General Practice Physical Activity Questionnaire tool. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Gray, B. J., Stephens, J. W., Williams, S. P., Davies, C. A., Turner, D., Bracken, R. M., on behalf of the Prosiect Sir Gar Group Tags: Original Articles Source Type: research

The associations between increasing degrees of homeostatic model assessment for insulin resistance and muscular strengthening activities among euglycaemic US adults
Conclusion: Having a higher homeostatic model assessment for insulin resistance value is associated with greater odds of reporting no muscular strengthening activity among euglycaemic US adults. This implies that subjects with an increasing degree of insulin resistance are more likely to not engage in muscular strengthening activity, an exercise modality that has been shown to reduce the risk of several cardiometabolic diseases and improve glycaemic status. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Boyer, W. R., Johnson, T. M., Fitzhugh, E. C., Richardson, M. R., Churilla, J. R. Tags: Original Articles Source Type: research

Serum adiponectin levels in patients with acute coronary syndromes: Serial changes and relation to infarct size
Conclusion: There was a small decrease in plasma adiponectin shortly after symptoms of ischaemia, more noticeable in women. No relationship was found between adiponectin and infarct size or clinical outcomes. This adds to evidence showing no clear association between adiponectin and adverse outcomes in patients with acute coronary syndromes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Alkofide, H., Huggins, G. S., Ruthazer, R., Beshansky, J. R., Selker, H. P. Tags: Original Articles Source Type: research

Effect of postprandial hyperglycaemia on coronary flow reserve in patients with impaired glucose tolerance and type 2 diabetes mellitus
Conclusion: Postprandial hyperglycaemia appears to have an adverse effect on coronary microvascular function, suggesting that improvement of postprandial hyperglycaemia may contribute to the improvement of coronary microvascular dysfunction. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Ikeda, H., Uzui, H., Morishita, T., Fukuoka, Y., Sato, T., Ishida, K., Kaseno, K., Arakawa, K., Amaya, N., Tama, N., Shiomi, Y., Lee, J.-D., Tada, H. Tags: Original Articles Source Type: research

Holter monitoring for the screening of cardiac disease in diabetes mellitus: The non-invasive Holter monitoring observation of new cardiac events in diabetics study
We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A total of 377 met inclusion criteria and were classified as low (n = 172), moderate (n = 136) and high risk (n = 69). In total, 86 in moderate and 53 in high risk receive further evaluation. In total, 29 in moderate and 25 in high risk were diagnosed as cardiac disease and 12 required additional treatment, includin...
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Nakao, Y. M., Ueshima, K., Nohara, R., Mizunuma, Y., Segawa, I., Tanaka-Mizuno, S., Yasuno, S., Nakao, K., Hiramori, K., Kihara, Y. Tags: Original Articles Source Type: research

Empagliflozin in diabetes: A therapeutic light at the end of the cardiovascular tunnel?
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Grant, P. J. Tags: Editorial Source Type: research