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Impact of exercise on diurnal and nocturnal markers of glycaemic variability and oxidative stress in obese individuals with type 2 diabetes or impaired glucose tolerance
Conclusion: Exercise significantly impacts the relationship between diurnal oxidative stress and nocturnal glycaemic variability in individuals with type 2 diabetes mellitus/impaired glucose tolerance. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Farabi, S. S., Carley, D. W., Smith, D., Quinn, L. Tags: Brief Reports Source Type: research

Cerebral autoregulation in pregnancies complicated by diabetes and overweight
Conclusion: Cerebral autoregulation is not impaired in pregnant women who have non-vasculopathic diabetes or overweight. This suggests that the increased risk of pre-eclampsia in diabetic and overweight women is not associated with early impaired cerebral autoregulation. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: van Veen, T. R., Panerai, R. B., Haeri, S., van den Berg, P. P., Zeeman, G. G., Belfort, M. A. Tags: Brief Reports Source Type: research

Fasting plasma triglyceride concentration: A possible approach to identify increased risk of statin-induced type 2 diabetes
Conclusion: Apparently, healthy, non-diabetic East Asian men and women with combined elevations of low-density lipoprotein cholesterol and triglyceride concentrations are glucose intolerant and insulin resistant, and thereby at enhanced risk of type 2 diabetes mellitus. Measurement of plasma triglyceride concentration can identify within a hypercholesterolemic population a subset of individuals at enhanced risk of statin-induced type 2 diabetes mellitus. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Sung, K.-C., Reaven, G. Tags: Original Articles Source Type: research

Association between diabetic retinopathy and subclinical atherosclerosis in China: Results from a community-based study
Conclusion: The presence of diabetic retinopathy was significantly associated with subclinical atherosclerosis in middle-aged and elderly patients with type 2 diabetics in China. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Liu, Y., Teng, X., Zhang, W., Zhang, R., Liu, W. Tags: Original Articles Source Type: research

Non-alcoholic fatty liver disease associated with increased arterial stiffness in subjects with normal glucose tolerance, but not pre-diabetes and diabetes
Conclusion: The effect of non-alcoholic fatty liver disease on arterial stiffness is apparent in subjects with normal glucose tolerance, but not in diabetes and pre-diabetes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Chou, C.-Y., Yang, Y.-C., Wu, J.-S., Sun, Z.-J., Lu, F.-H., Chang, C.-J. Tags: Original Articles Source Type: research

Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes
In conclusion, dapagliflozin 10 mg induces a modest reduction in blood pressure compared with placebo in patients with diabetes with a low risk of orthostatic reactions, regardless of baseline blood pressure. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Sjostrom, C. D., Johansson, P., Ptaszynska, A., List, J., Johnsson, E. Tags: Original Articles Source Type: research

The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
Conclusion: Vitamin D deficiency was significantly correlated with heart rate variability parameters. However, there was only borderline significant association between vitamin D concentration and presence of cardiac autonomic neuropathy. Therefore, future studies are required to establish a relationship between vitamin D levels and cardiac autonomic neuropathy. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Jung, C.-H., Jung, S.-H., Kim, K.-J., Kim, B.-Y., Kim, C.-H., Kang, S.-K., Mok, J.-O. Tags: Original Articles Source Type: research

Borderline ankle-brachial index is associated with increased prevalence of micro- and macrovascular complications in type 2 diabetes: A cross-sectional analysis of 12,772 patients from the Joint Asia Diabetes Evaluation Program
Borderline ankle–brachial index is increasingly recognised as a marker of cardiovascular risk. We evaluated the impact of borderline ankle–brachial index in 12,772 Chinese type 2 diabetes patients from the Joint Asia Diabetes Evaluation Program between 2007 and 2012. Cardiovascular risk factors, complications and health-related quality of life were compared between patients with normal ankle–brachial index (1.0–1.4), borderline ankle–brachial index (0.90–0.99) and peripheral arterial disease (ankle–brachial index < 0.9). The prevalence of peripheral arterial disease and borderli...
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Yan, B. P., Zhang, Y., Kong, A. P., Luk, A. O., Ozaki, R., Yeung, R., Tong, P. C., Chan, W. B., Tsang, C.-C., Lau, K.-P., Cheung, Y., Wolthers, T., Lyubomirsky, G., So, W.-Y., Ma, R. C., Chow, F. C., Chan, J. C., On behalf of the Hong Kong JADE Study Grou Tags: Original Articles Source Type: research

Effects of exercise training on HbA1c and VO2peak in patients with type 2 diabetes and coronary artery disease: A randomised clinical trial
Conclusion: No significant effects of exercise training on HbA1c or VO2peak were observed in patients with type 2 diabetes and coronary artery disease, although improvements were seen in patients without vascular complications beyond coronary artery disease, implying that the degree of vascular disease may influence exercise responses. Ventilatory threshold and time to exhaustion did increase significantly, indicating improved exercise performance despite the minor change in VO2peak. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Byrkjeland, R., Njerve, I. U., Anderssen, S., Arnesen, H., Seljeflot, I., Solheim, S. Tags: Original Articles Source Type: research

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance
In conclusion, 4 months of Nordic walking is an insufficient stimulus to improve vascular function. Future studies should consider hard endpoints in addition to measures of vascular health, as well as larger population groups, long-term follow-up and documented compliance to exercise training. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: Ring, M., Eriksson, M. J., Fritz, T., Nyberg, G., Ostenson, C. G., Krook, A., Zierath, J. R., Caidahl, K. Tags: Original Articles Source Type: research

Impact of diabetes on the benefits from everolimus-eluting stent as compared to first-generation drug-eluting stent in patients with ST elevation myocardial infarction
Conclusion: This study shows that among ST-segment elevation myocardial infarction patients undergoing primary angioplasty, diabetes is associated with a significantly worse outcome at 3-year follow-up. A similar outcome was observed between everolimus-eluting stent and first-generation drug-eluting stent in non-diabetic patients, whereas among diabetic patients everolimus-eluting stent was associated with a significant reduction in stent thrombosis. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 6, 2015 Category: Endocrinology Authors: De Luca, G., Sauro, R., Capasso, M., Lanzillo, T., Manganelli, F., Carbone, G., Lanni, F., Pagliuca, M. R., Palmieri, V., Serino, V., Rosato, G., Suryapranata, H., Di Lorenzo, E. Tags: Original Articles Source Type: research

Association of mitochondrial DNA haplogroups and vascular complications of diabetes mellitus: A population-based study
We investigated whether mitochondrial (mtDNA) haplogroups and maternal family history of diabetes mellitus were associated with vascular diabetes mellitus complications in a population-based cohort of 299 Finnish diabetes mellitus patients with disease onset in young adult age. We found that haplogroup U was more prevalent among patients with no vascular diabetes mellitus complications than among those with at least one complication (p = 0.038). Haplogroup U was also more prevalent among the patients who reported maternal family history of diabetes mellitus than among those who did not (p = 0.0013). Furthermore, haplogroup...
Source: Diabetes and Vascular Disease Research - June 22, 2015 Category: Endocrinology Authors: Martikainen, M. H., Ronnemaa, T., Majamaa, K. Tags: Letter to the Editor Source Type: research

Hyperhomocysteinaemia is associated with low plasma apolipoprotein AI levels in patients with impaired glucose tolerance
In conclusion, increased plasma homocysteine levels were associated with decreased apolipoprotein AI levels in impaired glucose tolerance subjects. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 22, 2015 Category: Endocrinology Authors: Liu, J., Wang, Y., Fan, H., Miao, L., Zhang, H., Wang, G. Tags: Brief Report Source Type: research

Glycated serum albumin stimulates expression of endothelial cell specific molecule-1 in human umbilical vein endothelial cells: Implication in diabetes mediated endothelial dysfunction
In conclusion, these results suggest that AGE-induced activation of human umbilical vein endothelial cells promotes formation of endocan which is an endothelial dysfunction marker and may be related to vascular disease in diabetes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - June 22, 2015 Category: Endocrinology Authors: Nirala, B. K., Perumal, V., Gohil, N. K. Tags: Original Articles Source Type: research

M1 and M2 macrophage proteolytic and angiogenic profile analysis in atherosclerotic patients reveals a distinctive profile in type 2 diabetes
This study aimed to investigate atherosclerotic mediators’ expression levels in M1 and M2 macrophages and to focus on the influence of diabetes on M1/M2 profiles. Macrophages from 36 atherosclerotic patients (19 diabetics and 17 non-diabetics) were cultured with interleukin-1β (IL-1β) or IL-4 to induce M1 or M2 phenotype, respectively. The atherosclerotic mediators’ expression was evaluated by quantitative reverse transcription-polymerase chain reaction (RT-PCR). The results showed that M1 and M2 macrophages differentially expressed mediators involved in proteolysis and angiogenesis processes. The pro...
Source: Diabetes and Vascular Disease Research - June 22, 2015 Category: Endocrinology Authors: Roma-Lavisse, C., Tagzirt, M., Zawadzki, C., Lorenzi, R., Vincentelli, A., Haulon, S., Juthier, F., Rauch, A., Corseaux, D., Staels, B., Jude, B., Van Belle, E., Susen, S., Chinetti-Gbaguidi, G., Dupont, A. Tags: Original Articles Source Type: research