Diabetes and Vascular Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Insulin resistance: The linchpin between prediabetes and cardiovascular disease
In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Salazar, M. R., Carbajal, H. A., Espeche, W. G., Aizpurua, M., Leiva Sisnieguez, C. E., Leiva Sisnieguez, B. C., Stavile, R. N., March, C. E., Reaven, G. M. Tags: Original Articles Source Type: research

Netrin-1 promotes mesenchymal stem cell revascularization of limb ischaemia
This study examines the effect and mechanism of action of Netrin-1 on bone marrow mesenchymal stem cells in angiogenesis. Tube formation and migration of bone marrow mesenchymal stem cells were observed in cell culture. Bone marrow mesenchymal stem cells or Netrin-1–bone marrow mesenchymal stem cells were injected into the ischaemic area of the rat hind limb on the first day after surgery. Laser Doppler perfusion imaging was performed to analyse the levels of vascular endothelial growth factor in plasma and muscles, and immunohistochemistry and immunofluorescence were used to analyse angiogenesis. Bone marrow mesench...
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Ke, X., Liu, C., Wang, Y., Ma, J., Mao, X., Li, Q. Tags: Original Articles Source Type: research

Role of myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability in vitro and in vivo
We have previously reported that advanced glycation end products activated Rho-associated protein kinase and p38 mitogen–activated protein kinase, causing endothelial hyperpermeability. However, the mechanisms involved were not fully clarified. Here, we explored the role of myosin light chain kinase in advanced glycation end product–induced endothelial hyperpermeability. Myosin light chain phosphorylation significantly increased by advanced glycation end products in endothelial cells in a time- and dose-dependent manner, indicating that myosin light chain phosphorylation is involved in the advanced glycation en...
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Wu, F., Guo, X., Xu, J., Wang, W., Li, B., Huang, Q., Su, L., Xu, Q. Tags: Original Articles Source Type: research

Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study
Conclusion: This study shows that increased DPP4 activities are strongly and independently associated with diabetic nephropathy in type 2 diabetes. The associations between DPP4 and diabetic nephropathy, although strong, do not imply causality. There are however plausible mechanisms which could explain such a link. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Zheng, T., Liu, Y., Qin, S., Liu, H., Zhang, X., Zhao, H. Tags: Original Articles Source Type: research

Empagliflozin reduces body weight and indices of adipose distribution in patients with type 2 diabetes mellitus
Conclusion: Empagliflozin significantly reduced weight and adiposity indices with the potential to improve cardiometabolic risk among patients with type 2 diabetes mellitus. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Neeland, I. J., McGuire, D. K., Chilton, R., Crowe, S., Lund, S. S., Woerle, H. J., Broedl, U. C., Johansen, O. E. Tags: Original Articles Source Type: research

Effect of treatment with rosiglitazone on high-sensitivity cardiac troponin levels among patients with type 2 diabetes mellitus
Conclusion: Rosiglitazone did not impact high-sensitivity cardiac troponin T levels, adding to the growing body of literature suggesting that the incremental heart failure risk associated with rosiglitazone is not mediated by direct myocardial injury. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Salahuddin, U. I., Pandey, A., Ayers, C. R., See, R., Neeland, I. J., Gore, M. O., Grinsfelder, D. B., Abdullah, S. M., Khera, A., de Lemos, J. A., McGuire, D. K. Tags: Original Articles Source Type: research

Non-haemodynamic anti-anginal agents in the management of patients with stable coronary artery disease and diabetes: A review of the evidence
Patients with coronary artery disease and concomitant diabetes mellitus tend to have more extensive vessel disease than non-diabetes mellitus coronary artery disease patients, are at high risk of adverse cardiovascular events and suffer from a great anginal burden. Very few trials have specifically addressed the issue of optimal anti-anginal therapy in coronary artery disease patients who also have diabetes mellitus. Among ‘classical’ anti-anginal agents, recent guidelines do not specifically recommend any molecule over others; however, European Society of Cardiology guidelines acknowledge that favourable data ...
Source: Diabetes and Vascular Disease Research - February 12, 2016 Category: Endocrinology Authors: Ambrosio, G., Tamargo, J., Grant, P. J. Tags: Review Article Source Type: research

Selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome
Conclusions: We are first to observe a selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome and suggest it as a pivotal molecular target for ameliorating insulin resistance and inflammation. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Jialal, I., Adams-Huet, B., Pahwa, R. Tags: Brief Report Source Type: research

Critical role of serum response factor in podocyte epithelial-mesenchymal transition of diabetic nephropathy
Conclusion: Together, increased serum response factor activity provokes podocytes’ epithelial–mesenchymal transition and dysfunction in diabetic nephropathy. Targeting serum response factor by small-molecule inhibitor may be an attractive therapeutic strategy for diabetic nephropathy. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Zhao, L., Wang, X., Sun, L., Nie, H., Liu, X., Chen, Z., Guan, G. Tags: Original Articles Source Type: research

Tribbles 3: A potential player in diabetic aortic remodelling
Tribbles 3, whose expression is up-regulated by insulin resistance, was confirmed to be involved in diabetic cardiomyopathy in our previous study. However, it is not known whether Tribbles 3 has a role on conduit arteries such as the aorta in diabetes. Type 2 diabetic rat model was induced by high-fat diet and low-dose streptozotocin. We evaluated the characteristics of diabetic rats by serial ultrasonography and histopathologic analyses of aortic wall architecture. Diabetic rats displayed increased aortic medial thickness, excessive collagen deposition, diminished elastic fibres and reduced vascular compliance together wi...
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Ti, Y., Xie, G.-l., Wang, Z.-h., Ding, W.-y., Zhang, Y., Zhong, M., Zhang, W. Tags: Original Articles Source Type: research

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis
Conclusions: These observations identify a potential role for liraglutide in the prevention of cardiac fibrosis and identify molecular mechanisms associated with these effects. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Gaspari, T., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W., Dear, A. E. Tags: Original Articles Source Type: research

Correlations between endothelial function in the systemic and cerebral circulation and insulin resistance in type 2 diabetes mellitus
In conclusion, endothelial function in the systemic and cerebral circulations is moderately correlated, provided that vascular reactivity estimates are corrected for non-endothelium-dependent influences. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Prakash, K., Chandran, D. S., Khadgawat, R., Jaryal, A. K., Deepak, K. K. Tags: Original Articles Source Type: research

Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study
This translational randomized and vehicle-controlled cross-over study was performed to assess the impact of haem arginate treatment on haem oxygenase-1 induction, endothelial function and insulin sensitivity in subjects with the metabolic syndrome (n = 14). Both treatment periods consisted of 5 days. Haem arginate or vehicle (l-arginine) was administered intravenously on Days 1 and 3. Forearm blood flow in response to acetylcholine and nitroglycerine was measured by venous occlusion plethysmography (Day 3), insulin sensitivity by a hyperinsulinaemic clamp procedure (Day 5). Haem arginate did not improve endothelial functio...
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Dekker, D., Dorresteijn, M. J., Peters, W. H., Bilos, A., Pennings, S. W., Wagener, F. A., Smits, P. Tags: Original Articles Source Type: research

Effects of comprehensive intensive therapies on the change of intima-media thickness of carotid arteries in type 2 diabetic patients: A report of 4-year follow-up with a literature review
Conclusion: The carotid intima-media thickness remained stable in type 2 diabetes mellitus patients who received comprehensive intensive therapy, suggesting that multi-factorial intensive therapies might have potential in reducing macro-vascular events in these patients. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Cheng, L.-J., Xu, Z.-R., Zhang, Q., Wang, Z.-D., Wu, F.-W., Yang, W.-X. Tags: Original Articles Source Type: research

Prevalence of macro- and microvascular complications in patients with type 2 diabetes and kidney disease with or without albuminuria in a single Chinese Diabetes Centre
Conclusion: The prevalence of diabetic retinopathy was graded according to the estimated glomerular filtration rate declining in albuminuric patients while the prevalence of low ankle-brachial index was gradually increased in normoalbuminuric patients, indicating the diverse underlying mechanisms of mild to moderate chronic kidney disease between these two phenotypes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 15, 2015 Category: Endocrinology Authors: Wu, D., Xuan, Y., Ruan, Y., Feng, X., Zhu, Y., Jia, C., Liu, J., Li, H., Li, L., Dong, X. Tags: Original Articles Source Type: research