Diabetes and Vascular Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

All-cause mortality and estimated renal function in type 2 diabetes mellitus outpatients: Is there a relationship with the equation used?
Conclusion: In our cohort of T2DM outpatients, different eGFR equations perform similarly in predicting ACM, whereas SCr did not. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 9, 2014 Category: Endocrinology Authors: Fabbian, F., De Giorgi, A., Monesi, M., Pala, M., Tiseo, R., Misurati, E., Parisi, C., Volpi, R., Graziani, R., Mikhailidis, D. P., Manfredini, R. Tags: Original Articles Source Type: research

Hyperbaric oxygenation modulates vascular reactivity to angiotensin-(1-7) in diabetic rats: Potential role of epoxyeicosatrienoic acids
Previously, a facilitating effect of hyperbaric oxygenation (HBO2) on aortic ring responses to angiotensin-(1-7) in healthy rats was reported, with epoxyeicosatrienoic acids (EETs) possibly playing an important role. The aim of this study was to assess whether HBO2 exerts similar effects in diabetic rats and to further explore the role of specific cytochrome P450 (CYP) enzymes in changes induced by HBO2. Aortic relaxation to angiotensin-(1-7) was significantly higher in HBO2 diabetic rats compared to control diabetic rats, while HBO2 had no effect on angiotensin II contraction. N-methylsulphonyl-6-(2-propargyloxyphenyl/hex...
Source: Diabetes and Vascular Disease Research - December 9, 2014 Category: Endocrinology Authors: Kibel, A., Novak, S., Cosic, A., Mihaljevic, Z., Falck, J. R., Drenjancevic, I. Tags: Original Articles Source Type: research

Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: Long-term follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort
Conclusion: An OGTT at discharge after AMI disclosed a high proportion of patients with previously unknown AGT which had a significant and independent association with long-term prognosis. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 9, 2014 Category: Endocrinology Authors: Ritsinger, V., Tanoglidi, E., Malmberg, K., Nasman, P., Ryden, L., Tenerz, A., Norhammar, A. Tags: Original Articles Source Type: research

Impaired glucose tolerance alters functional ability of peripheral blood-derived mononuclear cells in Asian Indian men
Conclusion: In pre-diabetic, Asian Indian men, PBMCs exhibit defective migration and homing potential. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - December 9, 2014 Category: Endocrinology Authors: Nathan, A. A., Charan Tej, M. A., Chitiprolu, M., Rangan, S., Mohan, V., Harish, R., Anand, S. B., Dixit, M. Tags: Original Articles Source Type: research

Direct effects of recurrent hypoglycaemia on adrenal catecholamine release
In Type 1 and advanced Type 2 diabetes mellitus, elevation of plasma epinephrine plays a key role in normalizing plasma glucose during hypoglycaemia. However, recurrent hypoglycaemia blunts this elevation of plasma epinephrine. To determine whether recurrent hypoglycaemia affects peripheral components of the sympatho-adrenal system responsible for epinephrine release, male rats were administered subcutaneous insulin daily for 3 days. These recurrent hypoglycaemic animals showed a smaller elevation of plasma epinephrine than saline-injected controls when subjected to insulin-induced hypoglycaemia. Electrical stimulation of ...
Source: Diabetes and Vascular Disease Research - December 9, 2014 Category: Endocrinology Authors: Orban, B. O., Routh, V. H., Levin, B. E., Berlin, J. R. Tags: Original Articles Source Type: research

Plasma copeptin as marker of cardiovascular disease in asymptomatic type 2 diabetes patients
This study aimed to evaluate whether plasma copeptin correlated to CVD in asymptomatic T2DM patients intensively investigated for sub-clinical CVD. A total of 302 T2DM patients referred to the Diabetes Clinic at Odense University Hospital, Denmark, entered the study. None of the patients had known or suspected CVD. As a control group, 30 healthy adults were recruited from the DanRisk study – a random sample of middle-aged Danes. A variety of clinical investigations were performed, including blood pressure measurements, carotid intima media thickness evaluation and myocardial perfusion scintigraphy. Blood sample analy...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Bar-Shalom, D., Poulsen, M. K., Rasmussen, L. M., Diederichsen, A. C., Sand, N. P., Henriksen, J. E., Nybo, M. Tags: Letter to the Editor Source Type: research

The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects
We report here the efficacy and safety of GFT505, a novel liver-targeted peroxisome proliferator-activated receptor alpha/delta (PPARα/) agonist, in the db/db mouse model of diabetes. Mice were treated with vehicle, GFT505, PPAR agonist rosiglitazone or dual-PPARα/ agonist aleglitazar for up to 8 weeks. All compounds comparably reduced fasting glycaemia and HbA1c and improved insulin sensitivity. The glucose-lowering effect of GFT505 was associated with decreased hepatic gluconeogenesis, correlating with reduced expression of gluconeogenic genes. In contrast with the PPAR-activating drugs, treatment with GFT505...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Hanf, R., Millatt, L. J., Cariou, B., Noel, B., Rigou, G., Delataille, P., Daix, V., Hum, D. W., Staels, B. Tags: Original Articles Source Type: research

Low-density lipoprotein cholesterol levels in adults with type 2 diabetes: An alternative equation for accurate estimation and improved cardiovascular risk classification
In conclusion, in T2DM, F-LDL-C underestimates M-LDL-C, with misclassifications that may potentially have an impact on therapeutic decisions in T2DM. The SMART2D equation improves accuracy of estimate, reducing misclassifications. Trials will be needed to ascertain the clinical significance of these findings. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Chai Kheng, E. Y., Chee Fang, S., Chang, S., Kiat Mun, S. L., Su Chi, L., Lee Ying, Y., Xiao Wei, N., Wern Ee, T., Biing Ming, S. L., Tavintharan, S. Tags: Original Articles Source Type: research

The effect of liraglutide on endothelial function in patients with type 2 diabetes
This single-centre, 12-week, double-blind, placebo-controlled trial assessed how the human glucagon-like-peptide 1 analogue liraglutide impacted endothelial function in adult patients (n = 49) with type 2 diabetes and no overt cardiovascular disease. Patients were randomized to liraglutide, placebo or glimepiride. At baseline and Week 12, venous occlusion plethysmography was used to measure forearm blood flow (FBF) in response to acetylcholine (ACh) and sodium nitroprusside (SNP) before and after l-NG-monomethyl arginine (L-NMMA) infusion. At Week 12, ACh-mediated FBF increased with liraglutide and decreased with placebo; ...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Nandy, D., Johnson, C., Basu, R., Joyner, M., Brett, J., Svendsen, C. B., Basu, A. Tags: Original Articles Source Type: research

The role of lectin-like oxidised low-density lipoprotein receptor-1 in vascular pathology
The lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a vascular scavenger receptor that plays a central role in the pathogenesis of atherothrombotic disease, which remains the main cause of mortality in the Western population. Recent evidence indicates that targeting LOX-1 represents a credible strategy for the management vascular disease and the current review explores the role of this molecule in the diagnosis and treatment of atherosclerosis. LOX-1-mediated pro-atherogenic effects can be inhibited by anti-LOX-1 monoclonal antibodies and procyanidins, whereas downregulation of LOX-1 expression has been ...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Shaw, D. J., Seese, R., Ponnambalam, S., Ajjan, R. Tags: Review Articles Source Type: research

The clinical burden of type 2 diabetes in patients with acute coronary syndromes: Prognosis and implications for short- and long-term management
Type 2 diabetes mellitus (T2DM) is associated with increased morbidity and mortality in patients with acute coronary syndromes (ACS). Cardiometabolic risk factors, including hyperglycaemia, insulin resistance, atherogenic dyslipidaemia, increased visceral fat and inflammation, are associated with increased risk in this population and represent potential targets for treatment. In this review, management strategies for patients with T2DM post-ACS, both in the acute-care setting and in the long-term, are discussed. Although the benefits of long-term, aggressive, multifactorial risk factor modification are well established, a ...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Katz, P., Leiter, L. A., Mellbin, L., Ryden, L. Tags: Review Articles Source Type: research

Diabetes and cancer: Epidemiology and potential mechanisms
Type 2 diabetes mellitus is an independent risk factor for cancer such as pancreatic, liver, colorectal and breast cancer. In addition, diabetes decreases the risk of prostate cancer. These associations have been found in numerous epidemiological studies, among them several prospective cohorts. However, such studies do not prove causality of the association and cannot exclude inadequate correction for known confounders (e.g. visceral fat) or the influence of unknown confounders. Thus, it is unclear whether the cancer risk is increased by the causes (e.g. the metabolic syndrome), the metabolic consequences (e.g. hyperglycae...
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Joost, H.-G. Tags: Invited Reviews Source Type: research

Antihyperglycaemic therapies and cancer risk
Conclusion: Although the molecular mechanisms are not fully understood, a potential risk of mitogenicity and tumour growth promotion cannot be excluded in case of several antidiabetic drug classes. However, more large-scale, randomized, well-designed clinical studies with especially long follow-up time periods are needed to get reliable answers to these safety issues. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Lutz, S. Z., Staiger, H., Fritsche, A., Haring, H.-U. Tags: Invited Reviews Source Type: research

Type 2 diabetes and cancer: Should we prefer antihyperglycaemic treatments without unnecessarily increasing insulin levels?
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 14, 2014 Category: Endocrinology Authors: Matthaei, S. Tags: Editorial Source Type: research

Back to the future: Examining type 2 diabetic vasculature using the gestational diabetic placenta
We report an interesting observation in a cohort of gestational diabetes mellitus foetal placental vasculature from South India. Transmission electron microscopy demonstrated pericyte detachment and pericyte ghost cells reminiscent of adult type 2 diabetic retinopathy, in gestational diabetes mellitus foetal placental blood vessels that were not observed in non-gestational diabetes mellitus placentas (p ≤0.001). Endothelial cell irregularity was observed in 76% gestational diabetes mellitus foetal blood vessels as compared with 10.4% non-gestational diabetes mellitus placental vasculature (p ≤0.001). Other abnormalit...
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Samuel, R., Ramanathan, K., Mathews, J. E., Seshadri, M. S. Tags: Letter to the Editor Source Type: research