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Evaluation of the role of left atrial strain using two-dimensional speckle tracking echocardiography in patients with diabetes mellitus and heart failure with preserved left ventricular ejection fraction
Conclusion: Two-dimensional speckle tracking echocardiography appeared as a useful additional tool for detection of left atrial dysfunction in patients with heart failure who have preserved left ventricular ejection fraction and diabetes mellitus who are especially prone to develop cardiovascular complications. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 14, 2016 Category: Endocrinology Authors: Georgievska-Ismail, L., Zafirovska, P., Hristovski, Z. Tags: Original Articles Source Type: research

London buses: A cardiovascular outcome trial equivalent?
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - October 14, 2016 Category: Endocrinology Authors: Grant, P. J. Tags: Editorial Source Type: research

The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
We examined the associations of the haptoglobin 2-2 genotype with C-reactive protein (high-sensitivity C-reactive protein) and carotid artery intima-media thickness, adjusting for age, gender, ethnicity, type 2 diabetes mellitus, smoking status, body mass index, blood pressure, glycated haemoglobin, non-high-density lipoprotein cholesterol and medications via logistic multivariate regression in 200 subjects (160 type 2 diabetes mellitus versus 40 healthy individuals). The prevalence of the haptoglobin 2-2 genotype was 58% (115/200), higher in the Indians than in Chinese (72% versus 45%, p = 0.001). Multivariate analysis sh...
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Dalan, R., Liew, H., Goh, L. L., Gao, X., Chew, D. E., Boehm, B. O., Leow, M. K. S. Tags: Brief Report Source Type: research

A preliminary study of brain macrovascular reactivity in impaired glucose tolerance and type-2 diabetes: Quantitative internal carotid artery blood flow using magnetic resonance phase contrast angiography
Conclusion: We have demonstrated significant cerebrovascular haemodynamic abnormalities in subjects with type 2 diabetes and impaired glucose tolerance. This was associated with greater sympathovagal imbalance. This may provide an important mechanistic explanation for increased risk of cerebrovascular disease in diabetes. It also highlights that these abnormalities may already be present in prediabetes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Selvarajah, D., Hughes, T., Reeves, J., Boland, E., Marques, J., Gandhi, R., Griffiths, P. D., Tesfaye, S., Wilkinson, I. D. Tags: Original Articles Source Type: research

Improvement of insulin sensitivity in response to exercise training in type 2 diabetes mellitus is associated with vascular endothelial growth factor A expression
Conclusion: The variation in physical adaptation to exercise training in diabetes mellitus type 2 was associated with changes in expression of vascular endothelial growth factor A in muscle. This difference in induced gene expression could contribute to the variation in exercise training effects on insulin sensitivity. Measures of capillary blood flow need to be assessed in future studies. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Wagner, H., Fischer, H., Degerblad, M., Alvarsson, M., Gustafsson, T. Tags: Original Articles Source Type: research

Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction
Conclusion: Patients with diabetes and macrovascular complications have increased amino acid ratios reflecting a shift in arginine metabolism due to arginase activation. These changes are inversely related to endothelial function supporting that arginase activity contributes to endothelial dysfunction. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Kövamees, O., Shemyakin, A., Pernow, J. Tags: Original Articles Source Type: research

The prevalence of major lower limb amputation in the diabetic and non-diabetic population of England 2003-2013
Conclusion: Diabetics continue to experience six times the rate of amputation than non-diabetics. However, half of major amputees were not diabetic and experienced slower rates of decrease. Non-diabetics, particularly those with peripheral arterial disease, should have access to appropriate services, particularly foot care. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Ahmad, N., Thomas, G. N., Gill, P., Torella, F. Tags: Original Articles Source Type: research

Negative association of diabetes with rupture of abdominal aortic aneurysm
Conclusion: Diabetes is negatively associated with abdominal aortic aneurysm rupture. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Takagi, H., Umemoto, T., for the ALICE (All-Literature Investigation of Cardiovascular Evidence) Group Tags: Original Articles Source Type: research

Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction
Conclusion: Diabetes mellitus is associated with features of adverse structural and functional cardiac remodelling in patients with chronic heart failure. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Walker, A. M., Patel, P. A., Rajwani, A., Groves, D., Denby, C., Kearney, L., Sapsford, R. J., Witte, K. K., Kearney, M. T., Cubbon, R. M. Tags: Original Articles Source Type: research

Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics
Conclusion: Echocardiographic abnormalities are very common in outpatients with type 2 diabetes, but neither cardiac symptoms nor clinical characteristics are effective to identify patients with echocardiographic abnormalities. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Jorgensen, P. G., Jensen, M. T., Mogelvang, R., von Scholten, B. J., Bech, J., Fritz-Hansen, T., Galatius, S., Biering-Sorensen, T., Andersen, H. U., Vilsboll, T., Rossing, P., Jensen, J. S. Tags: Original Articles Source Type: research

Myocardial dysfunction in diabetes: Another epidemic?
(Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - August 7, 2016 Category: Endocrinology Authors: Grant, P. J. Tags: Editorial Source Type: research

Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells
Conclusion: Our present results suggest that ranirestat has a stronger inhibitory activity on aldose reductase than epalrestat and suppresses inflammatory reactions in high glucose–exposed human umbilical vein endothelial cells. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - May 22, 2016 Category: Endocrinology Authors: Ishibashi, Y., Matsui, T., Matsumoto, T., Kato, H., Yamagishi, S.-i. Tags: Brief Reports Source Type: research

Copeptin, insulin-like growth factor binding protein-1 and sitagliptin: A report from the BEta-cell function in Glucose abnormalities and Acute Myocardial Infarction study
Conclusion: Sitagliptin therapy does not appear to be related to activation of the arginine vasopressin system. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - May 22, 2016 Category: Endocrinology Authors: Arnetz, L., Hage, C., Brismar, K., Catrina, S.-B., Norhammar, A., Lundman, P., Wallander, M., Ryden, L., Mellbin, L. Tags: Brief Reports Source Type: research

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes
Conclusion: Elevated high-sensitivity C-reactive protein and decreased soluble receptor for advanced glycation end products are associated with augmentation index and pulse wave velocity, respectively, suggesting the potential role of systemic inflammation in the pathogenesis of central arterial stiffness in type 2 diabetes. (Source: Diabetes and Vascular Disease Research)
Source: Diabetes and Vascular Disease Research - May 22, 2016 Category: Endocrinology Authors: Zhang, X., Liu, J. J., Fang Sum, C., Ying, Y. L., Tavintharan, S., Ng, X. W., Su, C., Low, S., Lee, S. B., Tang, W. E., Lim, S. C. Tags: Brief Reports Source Type: research

Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes
This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52 ± 11 years; 49% male) and 28 type II diabetes (aged 61 ± 9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation (p = 0.04) among type II diabetes participants and negatively among non-diab...
Source: Diabetes and Vascular Disease Research - May 22, 2016 Category: Endocrinology Authors: Veloudi, P., Blizzard, L., Srikanth, V. K., McCartney, P., Lukoshkova, E. V., Hughes, A. D., Head, G. A., Sharman, J. E. Tags: Brief Reports Source Type: research